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Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB (2000)

Haus-Seuffert, Philipp ; Meisterernst, Michael

Springer

Molecular and cellular biochemistry 212 (2000), S. 5-9

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ISSN: 1573-4919

Keywords: transcriptional regulation ; gene expression ; coactivator ; repressor

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1007111818628

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