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  • 1
    Electronic Resource
    Electronic Resource
    Nebulized budesonide after hospitalization for recurrent bronchial obstruction in children younger than 18 months (2001)
    Copenhagen, Denmark : Munksgaard International Publishers
    Pediatric allergy and immunology 12 (2001), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A multi-center, double-blind, randomized dose–response study was performed to assess the effect of 3 months of treatment with two different doses of inhaled nebulized budesonide in children with acute recurrent bronchial obstruction (BO) causing hospitalization. Steroid-naive children younger than 18 months were included when admitted to hospital because of BO for at least the second time, and were followed-up monthly for 15 months. Forty-five of 49 subjects (43 boys, 2 girls) (mean age 9.3 months upon inclusion) completed the study. Twenty-four patients (20 boys, 4 girls) received nebulized budesonide 0.5 mg twice daily for 1 month followed by 0.25 mg daily for the next 2 months, whereas 25 children received 0.1 mg twice daily throughout the 3-month treatment period. Outcome (number of BO episodes, time to first BO after start of treatment, and use of rescue medication), as well as height/length and weight, were assessed at the start of treatment and monthly for the following 3 months, as well as for 12 months after cessation of treatment (15 months in total). There was an overall tendency towards better symptom control (fewer episodes of acute BO during treatment and follow-up, fewer hospital visits because of acute BO, lower clinical score during follow-up, and less use of rescue medication during follow-up) in the high-dose treatment group vs. the low-dose treatment group. However, the differences did not reach statistical significance for any of the outcomes. The only significant difference in effect between the groups was fewer children in the high-dose group treated openly with nebulized budesonide during follow-up. Length/height and weight gain did not differ significantly between the two treatment groups throughout the study. There was no significant dose-dependent beneficial effect of 3 months of treatment with nebulized budesonide in infants and toddlers with at least two hospitalizations for acute bronchial obstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3038.2001.012003159.x
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  • 2
    Electronic Resource
    Electronic Resource
    The radioallergosorbent test in the in vitro diagnosis of multiple reaginic allergy (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 4 (1974), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The results of skin and bronchial tests and of the radioallergosorbent test (RAST) with allergen extract preparations from two different producers were compared. Eleven allergic children were tested with dog allergens and, with one exception, with birch and timothy pollen allergens. Both types of allergen extract preparation were standardized with respect to their allergenic activity. A good correlation was found between the results of the clinical diagnostic tests and the results of RAST. RAST and skin testing were equally effective as a supplement to case history for predicting the presence or absence of clinical allergy to the particular allergens. A good agreement was obtained in the results with the two different extract preparations. It was concluded that different preparations of allergen extracts may be used interchangeably in the in vivo and the in vitro systems on condition that all extract preparations have been standardized with respect to biological allcrgenic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1974.tb01402.x
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  • 3
    Electronic Resource
    Electronic Resource
    The radioallergosorbent test (RAST) in the diagnosis of reaginic allergy (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 4 (1974), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Provocation tests, skin tests, and RAST were performed in 156 asthmatic children, using eleven different allergens (moulds, animal danders, and pollens). A total of 305 positive and 676 negative provocation tests were performed. For positive provocations there was an overall agreement with RAST in 61% of the instances, for negative bronchial tests in 94%. The agreement was found to be allergen dependent. By combining RAST and skin tests, it was possible to arrive at a conclusive allergy diagnosis in a higher number of instances than if either skin testing or RAST was used alone, but in a considerable number of instances provocation tests were found to be necessary to secure the allergy diagnosis. The results obtained with RAST in this study were less favourable than those of other studies, probably because of the use of lower quality allergosorbent material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1974.tb01401.x
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  • 4
    Electronic Resource
    Electronic Resource
    A placebo controlled trial of fluticasone propionate in asthmatic children (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 856-860 
    Details
    ISSN: 1432-1076
    Keywords: Asthma ; Children ; Fluticasone propionate ; Clinical trial ; HPA-axis function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fluticasone propionate is a synthetic steroid for use by the inhaled route. It's high topical potency and low systemic bioavailability make it suitable for use in asthmatic children. A total of 258 children were randomised in a double-blind study to receive fluticasone propionate (50 μg bd) as the dry powder formulation inhaled via a Diskhaler inhaler, or matched placebo (with current therapy) for 4 weeks throughout which time diary cards were completed. During clinic visits lung function and adrenal function were measured. Fluticasone propionate produced a significantly greater increase in morning peak expiratory flow rate (PEFR) (adjusted mean difference over days 1–28, 17 l/min (95% CI; 10, 24);P〈0.001) and evening PEFR (adjusted mean difference over days 1–28, 16 l/min (95% CI; 9, 23);P〈0.001). In addition, diary card symptom scores, beta2-agonist rescue and clinic lung function improved significantly on fluticasone propionate. There were few adverse events and basal plasma cortisol remained within the normal range. In conclusion fluticasone propionate at 50 μg bd is superior to placebo (current therapy) in the treatment of childhood asthma with no evidence of adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02073387
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    Paper (German National Licenses)
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