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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 21 (1989), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report 6 cases of contact sensitivity to croconazole hydrochloride, a new imidazole antimycotic drug introduced to the Japanese market in 1986. and available as 1% gel and cream, 6 sensitized patients reacted on patch testing in cruconazole hydrochloride down to 0.5 to 0.1% pet, and 3 appeared to be cross-sensitized to sulconazole nitrate. In Japan, allergic contact dermatitis to this drug has now been detected in 12 cases, including our own 6. Prescribes should be aware of contact sensitivity lo this drug.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 229 (1991), S. 473-479 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The process of corneal neovascularization induced by alkali burns was periodically observed with a newly developed macroscope. The central corneas were burned using filter discs measuring 6 mm in diameter that had been immersed in 1 N NaOH. At 0, 1, 3 and 7 days and at 2, 3 and 4 weeks after injury, the corneas were observed with the macroscope and then examined histologically. At 1 day post-burn, the limbal vascular plexus was engorged but no new vessel formation was detected. By 3 days, many vascular sprouts had arisen from the limbal vascular arcade. At 7 days, the vascular sprouts grew and became fine new vessels. At 2 weeks, the new vessels lengthened further to the central cornea. At 3 weeks, trunk vessels extended and branched like a vascular tree. Blood in the trunk vessels appeared to flow slowly to and fro. The ends of the vessels swelled in a fusiform shape on the application of slight pressure of the macroscope probe. Histological examination revealed that the ends of the vessels consisted of single vascular endothelial cells and the trunk vessels were covered by pericytes. By 4 weeks, the branch vessels around the burned lesion had degenerated and collapsed. Thus, our in vivo study using the new macroscope not only clarified the process of corneal neovascularization from the early to the regressive phases but also provided some valuable new information.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In patients with advanced biliary malignancies a chance of curability is obtained by performing only major hepatectomy with concomitant pancreatoduodenectomy. This aggressive procedure carries two major risks: hepatic failure and pancreatic anastomotic leakage. Ten patients with advanced biliary malignancies were treated by major hepatectomy with pancreatoduodenectomy. Nine patients underwent right portal venous embolization before hepatectomy. Complete external drainage of pancreatic juice followed by second-stage pancreatojejunostomy was performed in five patients. Three of these five underwent concomitant resection of the hepatic artery, portal vein, or both. Pancreatogastrostomy was chosen for five patients who required no concomitant vascular resection. There were no hospital deaths or hepatic failures. Leaks from pancreatogastrostomy occurred in two patients. In five patients who underwent external drainage of pancreatic juice, there were no complications related to the pancreatic stump, although one had ischemic necrosis of the jejunal segment and laparotomy was repeated. Mean survival time was 31.8 months (range 13–59 months). Portal venous embolization and complete external drainage of pancreatic juice followed by late stage pancreatojejunostomy are recommended surgical procedures for patients undergoing major hepatectomy with pancreatoduodenectomy, especially when concomitant vascular resection is required for curative resection of the tumor in patients with a soft pancreatic parenchyma and thin pancreatic duct.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats de 122 résections hépatiques chez 112 patients ayant un carcinome hépatocellulaire (CHC) sont décrits. Le type de résection a été choisi selon la fonction hépatique. Quarante neuf patients ont eu une résection anatomique y compris un cas de trisegmentectomie, cinq lobectomies, 11 segmentectomies, et 32 sous segmentectomies; les 63 autres patients ont eu une résection non anatomique. Les survies à 1, 2 et 3 ans après résection hépatique pour tous les patients, en tenant compte d'un décès hospitalier et d'un décès préopératoire (0.9%), ont été de 92%, 85% et de 78.9% alors que la survie sans tumeur a été de 68.6%, de 46.2% et de 32.6%, respectivement. Vingt et une résections secondaires ont été réalisées (17.2% au total des 122 résections) sans mortalité hospitalière. La survie cumulative depuis le moment de la deuxième résection chez ces 21 patients a été de 84.2% et de 56.3% à 1 et à 2 ans, respectivement. Parmi les facteurs influençant la survie sans tumeur, il faut noter l'absence d'envahissement vasculaire (p〈0.05) et l'absence de métastases hépatiques (p〈0.001). L'évolution après résection pour CHC est bonne grâce à une indication appropriée, un suivi rigoureux et une attitude thérapeutique agressive en cas de récidive.
    Abstract: Resumen Se describen los resultados de 122 resecciones hepáticas en 112 pacientes con carcinoma hepatocelular. El tipo de resección efectuado se seleccionó con base en el estado de la función hepática. Cuarenta y nueve pacientes tuvieron resección anatómica, incluyendo una trisegmentectomía, 5 lobectomías, 11 segmentectomías y 32 subsegmentectomías, y los 63 pacientes restantes tuvieron resecciones no anatómicas. Las tasas de sobrevida a 1, 2 y 3 años luego de resección hepática, teniendo en consideración una muerte operatoria y una muerte hospitalaria (0.9% cada una) fuerin 92.4%, 85% y 78.9%, en tanto que las tasas de sobrevida libre de enfermedad a 1, 2 y 3 años fueron 68.6%, 46.2% y 32.6%, respectivamente. Se realizaron 21 resecciones hepáticas repetidas (17.2% del total de las 122 resecciones) sin mortalidad hospitalaria. La tasa acumulada de sobrevida desde el momento de la nueva hepatectomía en estos 21 pacientes fue 84.2% y 56.3% a 1 y 2 años, respectivamente. Entre los factores que pueden afectar la sobrevida o el intervalo libre de enfermedad, la ausencia de invasión vascular (p〈0.05) y las metástasis intrahepáticas (p〈0.01) aparecieron significativamente relacionadas con el intervalo libre de enfermedad. Se demuestra un buen resultado luego de la resección hepática en 112 pacientes con carcinoma hepatocelular mediante una escogencia apropiada del tipo de resección, un seguimiento cuidadoso y un vigoroso aproche quirúrgico en presencia de recurrencia.
    Notes: Abstract The results of 122 hepatic resections in 112 patients with hepatocellular carcinoma are described. The type of liver resection performed was selected according to the patient's liver function. Forty-nine patients underwent anatomic resections, including 1 trisegmentectomy, 5 lobectomies, 11 segmentectomies, and 32 subsegmentectomies; the remaining 63 patients had nonanatomic resections. The 1-, 2-, and 3-year survivals after liver resection for all patients, taking into account one operative and one hospital death (0.9% each), were 92.4%, 85.0%, and 78.9%, and disease-free survivals at 1, 2, and 3 years were 68.6%, 46.2%, and 32.6%, respectively. Twenty-one repeat hepatic resections (17.2% of the total of 122 resections) were performed with no hospital mortality. Cumulative survival from the time of repeat hepatectomy in these 21 patients was 84.2% and 56.3% at 1 and 2 years, respectively. Among the factors that may affect survival or disease-free survival, the absence of vascular invasion (p〈0.05) and intrahepatic metastases (p〈0.01) were significantly related to the disease-free survival time. A good outcome was obtained after liver resection in 112 patients with hepatocellular carcinoma through appropriate choice of the type of resection, careful follow-up, and a vigorous surgical approach for recurrence.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 241 (1987), S. 1-8 
    ISSN: 1432-0711
    Keywords: DNA polymerase α and β ; Human placenta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Activities of DNA polymerase α and β were assayed in crude extracts prepared from human placenta. Polymerase α activity was high in early pregnancy but low during the 2nd trimester. Polymerase β activity did not change significantly with gestational weeks. The increase in polymerase α activity in early pregnancy may be closely related to mitosis at the time of placental formation; there might also be some type of accelerating factor for polymerase in early pregnancy.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1437-7780
    Keywords: Key words Vancomycin hydrochloride (VCM) ; Impaired liver function ; Pharmacokinetics ; Protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Infections caused by methicillin-resistant Staphylococcus aureus pose a serious problem postoperatively. Patients with hepatic dysfunction can be considered to be more susceptible to infection. Since little is known about the effects of the severity of hepatic dysfunction on the pharmacokinetics of vancomycin, we studied the pharmacokinetics of vancomycin in preoperative patients with hepatic dysfunction, after the intravenous infusion of 500 mg. In patients with liver disease and normal renal function, an enhancement of renal clearance caused by a reduction in percent protein binding was canceled out by a reduction in non-renal clearance caused by liver dysfunction, resulting in liver disease having no effect on the total clearance of the drug. In patients with impaired liver and renal functions and/or obstructive jaundice, the unbound fraction of vancomycin increased, whereas the renal excretion of vancomycin was delayed. It should be noted that an excessive increase in blood vancomycin concentration may be brought about even with a conventional dose in patients with hepatic dysfunction.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 100 (1991), S. 71-78 
    ISSN: 1573-4919
    Keywords: Y-chromosome ; Y-chromosome specific DNA ; repetitive DNA ; antenatal diagnosis ; fetal sex determination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Four Y-specific DNAs of different sizes were isolated by screening a human Y-chromosome gene-library. After determining their structural characteristics, the possibility for their clinical application was examined. The results are as follows: 1. The 4 cloned DNAs had inserts of 3.3, 2.0, 1.9 and 1.4 kb; they were subcloned into plasmid pUC19, and designated pKY-2, pKY-3, pKY-4 and pKY-5, respectively. 2. All four clones hybridized specifically with the Y-specific 3.5 kb DNA but not with female DNA. However, they did not cross-hybridize with the 2.1 kb fragment known to be another Y-specific repetitive DNA of human genomes. 3. The newly cloned probes were applied to the detection of Y-specific DNA in abnormal Y-chromosomes [Turner Syndrome (45, X/46, X, −X, + marker), 46, XY-female, mosaicism (46, XY/47, XYY), 46, XX-male and super male (47, XY 4. Since the newly cloned DNAs did not hybridize with other eukaryotic genome DNAs such as monkey, rat, mouse, chicken, frog, or fish, their human gene specificities were confirmed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of assisted reproduction and genetics 12 (1995), S. 330-334 
    ISSN: 1573-7330
    Keywords: mouse embryo ; platelet activating factor (PAF) ; PAF antagonist (CV6209) ; in vitro implantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose Our purpose was to assess the role of platelet activating factor (PAF) in embryo implantation, we examined the effects of PAF and a PAF antagonist on the in vitro implantation of mouse embryos, using an in vitro embryo culture system in the absence of the endometrium. Methods BDF1 mouse pronuclear-stage embryos were cultured until they developed to the two-cell, the four- to eight-cell, or the morula stage in the absence of PAF or its antagonist CV6209. The medium was then changed and supplemented with PAF or CV6209 at various concentrations. We also examined the reversible effects of PAF addition to the media containing the PAF antagonist. Results The addition of PAF to the culture from the two-cell stage significantly (P 〈0.05) increased the rates of embryo implantation in vitro (control, 69.8%; 10 −10 MPAF, 90.1%; 10 −9 MPAF, 95.5%). Similarly, the addition of PAF to the cultures from the four- to eight-cell and morula stage also significantly (P 〈0.05) increased their rates of implantation in vitro. In contrast, the addition of CV6209 to the culture significantly (P 〈0.01) decreased the rates of embryo implantation in vitro. CV6209 also decreased the rate of blastocyst formation. The degree of inhibition by CV6209 decreased with the advancing stage of embryos. The addition of PAF to media containing CV6209 reversed the inhibition and restored the implantation rate in vitro. Conclusions These results suggest that PAF may act directly on the mouse embryo and favor its implantation like an autocrine activating factor, irrespective of the presence or absence of the endometrium.
    Type of Medium: Electronic Resource
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