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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Biochemical genetics 11 (1974), S. 475-486 
    ISSN: 1573-4927
    Keywords: lipoprotein ; Lp(a) of human plasma ; quantitative genetics ; polygenic model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Lp(a) lipoprotein [Lp(a)] was quantified in 1251 adults, including 300 mother-father-offspring triplets, by a sensitive radial immunodiffusion assay. Lp(a) was not correlated with age, sex, or cholesterol or glyceride concentrations. Significant correlations were found between mother-offspring (r=0.34), father-offspring (r=0.40), and midparent-offspring (r=0.52), whereas no correlation was found between husband-wife pairs (r=0.02). Analysis of triplets separated on the basis of midparent Lp(a) concentrations indicated a resemblance of midparent to offspring regardless of midparent concentration. Bimodality was not detected in any of the offspring distributions. These data are compatible with the hypothesis that the observed quantitative Lp(a) variation is determined by a polygenic model of inheritance. The possibility of major gene effects is not ruled out.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Geriatric nephrology and urology 9 (1999), S. 177-182 
    ISSN: 1573-7306
    Keywords: Aging ; Aging kidneys ; Aging population
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The `demographic imperative' of a progressively aging society willplace unprecedented demands on the health care system in the 21stcentury. Although improved education, public health measures,personal lifestyles, and health care will result in a large proportionof those born surviving to old age in robust health and vitality, thesheer numbers of `baby-boomers' who will become the elderly and theinevitable association between aging and the associated multiple,especially chronic diseases and physiological impairments of oldage will require more efficient and more effective systems of healthcare to meet the needs of the aging population. Generalists, specialists,and medical and surgical subspecialists will play important rolesin meeting these needs, often in the multidisciplinary mode.Geriatricians will directly provide but a small minoritty of thecare, focusing upon education, research, and consultation and indelivering primary care to the frail elderly and especially inlong term care. Collaboration with subspecialists will be frequentin all these domains. Nephrologists, who already practice multidisciplinaryteam care of frail, complicated, chronically in patients with end-stagerenal disease, have much to contribute as their patient populationprogressively grows in numbers and age. Hence geriatricians and nephrologists have much to learn from and contribute to each other in addressing the `age wave' of the 21st century.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 32 (2000), S. 137-146 
    ISSN: 1573-2584
    Keywords: Aging ; Demography ; Chronic disease ; Old age ; Health care expenditures ; Medicare ; Long-term care ; Medical subspecialities ; Nephrology ; Internists ; Family practitioners ; Neurology ; Phychiatry ; Rehabilitation ; General surgery ; Surgical subspecialties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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