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  • 1
    Electronic Resource
    Electronic Resource
    Immunology of hepatitis B virus infections (1989)
    Springer
    Rheumatology international 9 (1989), S. 167-173 
    Details
    ISSN: 1437-160X
    Keywords: Hepatitis B virus ; HBV, extrahepatic manifestations of ; HBsAg ; HBeAg ; HBV, immune complexes of ; HBV, immune response against
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute or chronic hepatitis B virus infection is often associated with symptoms which are probably caused by immune complexes, such as vasculitis, glomerulonephritis and arthritis. The immune complexes found in such patients contain excessive viral proteins. The functions of these proteins and the immune response to them during various states of infection are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271875
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cell type specific expression of pre S 1 antigen and secretion of hepatitis B virus surface antigen (1987)
    Springer
    Archives of virology 96 (1987), S. 249-256 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Production of the three hepatitis B surface (HBs) proteins was studied in a hepatoma cell line (PLC/PRF/5) and two HBs antigen secreting cell lines (HeLa and mouse L-cells), which had been transfected by a viral genome isolated by molecular cloning from PLC/PRF/5 chromosomal DNA. The DNA used for transfection contains the HBs-specific promoters and the enhancer which regulate the expression of HBs genes in the transfected cell lines. All three cell lines expressed well the small and middle HBs protein, but the larger pre S 1 containing protein was barely detectable in the L-cell. In vivo growth of the transfected HeLa cell as nude mouse tumour increased pre S 1 expression and suppressed secretion of HBsAg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01320964
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Association of hepatitis C virus in human sera with β-lipoprotein (1992)
    Springer
    Medical microbiology and immunology 181 (1992), S. 293-300 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatitis C virus (HCV)-RNA in sera of patients with viral hepatitis C is supposed to be included, at least partially, into HCV particles. We found that the density of HCV-RNA-carrying material was variable, as determined by sucrose gradient density centrifugation (1.03–1.20 g/cm3). In some of the sera examined HCV-RNA was restricted to low densities between 1.03 and 1.08 g/cm3. In other sera additional densities of HCV-RNA were found distributed over the whole gradient with peaks at 1.12 and 1.17 and at 1.19–1.20 g/cm3. HCV-RNA banding at low densities could be completely co-precipitated with anti-β lipoprotein, whereas HCV-RNA fractions of higher densities were only partially precipitated or not at all. In 8 of 20 sera directly examined, HCV-RNA could be completely and in 9 sera only partially co-precipitated by anti-β lipoprotein. In 3 sera no significant precipitation could be observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198849
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Assay of preS epitopes and preS1 antibody in hepatitis B virus carriers and immune persons (1990)
    Springer
    Medical microbiology and immunology 179 (1990), S. 49-60 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diagnostical significance of the large hepatitis B surface protein with its preS1 attachment site and of anti-preS antibodies are not yet well known. We investigated the epitope of the preS1 attachment site to see whether it is a marker of viremia and whether antibodies against it occur in convalescents and vaccinees. For comparison, sera were also tested for the presence and relative amount of a preS2 epitope. The epitopes were detected by binding to specific monoclonal antibodies (mAb MA18/7 for the preS1 epitope and mAb Q19/10 for the preS2 epitope) at the solid phase of a sandwich enzyme-linked immunosorbent assay. Antibody against the preS1 epitope was detected by inhibition of binding to mAb MA18/7. This mAb inhibits attachment of preS1 antigen to hepatocytes and reacts with a subtypeindependent sequential epitope at the surface of hepatitis B virus between amino acid 29–36. This preS1 epitope occurs in most hepatitis B surface antigen (HBsAg) carriers, irrespective of viremia. Free preS2 epitope Q19/10 is present in samples with more than 8 μg/ml total HBsAg and it is masked in sera with less HBsAg. Antibodies which compete with mAb MA18/7 for its viral preS1 epitope occur in one third of HBsAg carriers who were negative for hepatitis B e antigen. It also occurs in one third of convalescents and in most good responders to plasma-derived vaccines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190150
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    Paper (German National Licenses)
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