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  • 1
    Electronic Resource
    Electronic Resource
    P02
Analysis of coupled patch test reactions to nickel, cobalt and chromate (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Concomitant sensitizations to Nickel, Cobalt and Chromate are often observed among patch test patients. However, the reasons for being sensitized to two or more of these substances are not completely understood. Examination of IVDK () patch test results with multivariate procedures has been conducted to further elucidate the mechanisms involved with these sensitizations and potential exposure factors that may have led to the concomitant sensitizations. Gender, age, occupational dermatitis, and construction work were considered and examined with multivariate logistic regression models with the dependent response variable being concurrent reactions to a metal pair versus no reactions. In addition to the aforementioned anamnestic data, examination of a poly-sensitizations variable (reactions to 1, 2, or 3 standard series allergens other than Nickel, Cobalt or Chromate) provided information regarding general susceptibility to positive patch test reactions. Combined reactions to Cobalt and Chromate were strongly linked to construction work (OR = 11.23 (7.46, 16.90)) and occupational dermatitis. Female patch test patients had a higher odds of a positive patch test reaction to both Nickel and Cobalt (OR = 4.73 (3.81, 5.87)). Sensitization to other, unrelated standard series substances was associated with concurrent reactions to all of the metal pairs. The association between construction work and Cobalt-Chromate reactions corresponds with the hypothesis that cement exposures lead to cobalt-chromate sensitizations. Individual susceptibility to delayed-type sensitizations, as represented by the poly-sensitization variable, also appears to be associated with coupled sensitizations to metals and warrants further examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.00309ej.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    FC02.4
Meteorological factors and standard series patch test reactions (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The existence of seasonal patterns to patch test reactions has been described, but with conflicting causal interpretations. The potential seasonality of patch tests may be due to irritation, changes to skin barrier or changes to immunological functions caused by meteorological fluctuations. For example, increased skin irritability due to cold winter weather and low humidity may cause an increase in irritative/doubtful and weak positive (false positive) reactions. To investigate the extent of the association between weather and patch test results, consecutive patients (N = 73691) patch tested with the standard series of the German Contact Dermatitis Research Group (DKG) at German or Austrian IVDK () centres were matched with weather data collected at a nearby (30 km radius) weather station. Temperature and absolute humidity (AH) on the day of patch test application and the two preceding days were averaged to represent the environment most likely to have influenced the skin condition at the time of testing. The results of 24 standard series substances were analyzed with multivariate logistic regression. Half of the standard series substances examined, including fragrance mix, nickel sulphate, and formaldehyde, exhibited evidence of a relationship with meteorological conditions. Fragrance mix and p-Phenylene diamine exhibited the strongest evidence of an association to weather, with the odds of the reactions in all three reaction categories (ir/?, +, ++/+++) increasing during winter conditions. Due to the association between weather and patch test reactivity, the potential effect of meteorological conditions should be considered in the interpretation of patch test reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309ba.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A multilingual European patch test software concept: WinAlldat/ESSCA (2003)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.0225n.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The association between ambient air conditions (temperature and absolute humidity), irritant sodium lauryl sulfate patch test reactions and patch test reactivity to standard allergens (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 49 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To support the decision as to whether erythematous patch test reactions to allergens are irritant or allergic, sodium lauryl sulfate (SLS, 0·5% in water) has been added to the standard patch tests since July 1996 in the Dortmund Department of Dermatology. Data on 1600 patients patch tested up until June 2001, as well as standardized data on ambient temperature and humidity obtained by the German Meteorological Service, were included in a logistic regression analysis taking age, sex and atopy as potential confounders into account. The pattern of association was heterogeneous: while doubtful reactions to nickel sulfate were significantly associated with dry/cold weather conditions, but not with SLS reactivity, the opposite was observed for lanolin alcohol, benzocaine and Myroxylon pereirae resin (balsam of Peru). Doubtful reactions to other allergens, namely formaldehyde, fragrance mix or p-phenylenediamine, were associated with both factors. For several other allergens of the standard series, no distinct, significant pattern could be discerned. In conclusion, meteorological conditions and SLS reactivity independently contribute information on individual irritability at the time of patch testing, and both should be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2003.00178.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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