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  • 1
    Electronic Resource
    Electronic Resource
    Total anomalous origin of the coronary arteries from the pulmonary artery (1986)
    Springer
    Pediatric cardiology 7 (1986), S. 11-18 
    Details
    ISSN: 1432-1971
    Keywords: Coronary vessel anomalies ; Congenital heart disease ; Coronary artery origin from pulmonary artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinicopathologic features of four patients with total anomalous origin of the coronary arteries from the pulmonary artery (TCAPA) are presented and compared with 21 previously reported cases. Patients with TCAPA usually present with left ventricular heart failure, angina, or associated cardiovascular anomalies. Of the 19 patients in whom a clinical history was available, 16 were symptomatic before three days of age. All patients died with 60% dying before two weeks of age. Longer survival was associated with additional cardiovascular anomalies that increased pulmonary arterial perfusion pressure, oxygen saturation, or both. Seventeen (68%) patients had additional cardiovascular anomalies, most commonly atrial (nine cases) or ventricular (eight cases) septal defects and tetralogy of Fallot or other variants of pulmonary atresia (four cases). Only five (22%) of 23 had noncardiovascular anomalies. The coronary arteries arose equally from either one ostium or from two, and the number of ostia was not related to either anomalous coronary artery distribution or to the presence of additional cardiovascular anomalies. Cardiomegaly was present in 56% of cases and the majority of patients had myocardial fibrosis or infarction. Embryology is reviewed and evidence is presented to support the theory of involution-persistence of coronary artery anlagen as the pathogenetic mechanism of TCAPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02315476
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Development of behavioral tolerance to morphine and methadone using the schedule-controlled behavior of the pigeon (1971)
    Springer
    Psychopharmacology 19 (1971), S. 40-52 
    Details
    ISSN: 1432-2072
    Keywords: Tolerance ; Behavior ; Morphine ; Methadone ; Pigeons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A multiple fixed-ratio, fixed-interval schedule of food presentation was used to study the development of behavioral tolerance to daily injections of equipotent doses of morphine and methadone in the pigeon. There was evidence that tolerance was developing to the rate-decreasing effects of both drugs after a single injection. Tolerance to morphine developed more rapidly during the first week of injections than did tolerance to methadone. Tolerance to the depressant effects of morphine and methadone was less complete under the fixed-ratio component of the schedule than under the fixed-interval component. After repeated injections, increases in the rate of responding were observed in some birds. These increases depended on the bird, rather than on the narcotic. Thus, the development of tolerance was a function of the drug, of the individual bird, and of the schedule maintaining the behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403701
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Candida Funisitis: A Clinicopathologic Study of 32 Cases (1998)
    Springer
    Pediatric and developmental pathology 1 (1998), S. 118-124 
    Details
    ISSN: 1615-5742
    Keywords: Key words: Candida, funisitis, umbilical cord, placenta, fetus, infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT We report on 32 cases of Candida funisitis and describe the associated clinicopathologic features. The Candida funisitis was characterized grossly by small, circumscribed, yellow-white nodules on the umbilical cord surface and, microscopically, by subamnionic microabscesses in which fungal organisms were demonstrable. Chorioamnionitis was present in all cases. Twenty-four (75%) of the 32 infants were premature. There were 7 perinatal deaths, all in immature fetuses. Five (16%) of the 32 fetuses had congenital candidiasis. Five (16%) of the mothers had a history of intrauterine foreign body, including intrauterine contraceptive device in three and cervical cerclage in two. The diagnosis of Candida funisitis should prompt a careful examination for fetal infection, even though it is associated with congenital candidiasis in only a minority of the cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100249900014
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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