ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Incidence of cervical smears indicating dysplasia among Austrian women during the 1980s (1995)

Kainz, Christian ; Gitsch, Gerald ; Heinzl, Harald ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

BJOG 102 (1995), S. 0

add to mindlist on the mindlist

Details

ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Objective To determine the incidence of cervical smears indicating cervical intraepithelial neoplasia during the 1980s and to compare two quinquennia.Design A retrospective epidemiologic analysis was performed, based on a large collection of 238261 cervical smears obtained from Austrian women screened between 1980 and 1989. After application of strict epidemiologic criteria to avoid bias of changes in socio-economic status and methodological changes in cytology, 12604 women were eligible for further analysis. We calculated incidences and relative risks of cytologically indicated cervical intraepithelial neoplasia, comparing the time periods of 1980 to 1984 and 1985 to 1989 for different age cohorts.Results We found a statistically significant increase in the incidence of cervical cytology indicating cervical intraepithelial neoplasia in the second time period for patients between 21 and 40 years of age. Women older than 40 years showed a significant decrease of this incidence.Conclusions In Austrian women between the ages of 21 and 40 years an unidentified risk factor or a pattern of risk factors during the period prior to 1985 resulted in an increase of cervical intraepithelial neoplasia during the last years studied. This increasing incidence of cervical intraepithelial neoplasia indicates the importance of regular cytological screening. The significant decrease of the cervical intraepithelial neoplasia incidence in women older than 40 years provides an argument for increasing screening intervals in these women.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb11357.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

A note on testing areas under the curve when using destructive measurement techniques (1996)

Heinzl, Harald

Springer

Journal of pharmacokinetics and pharmacodynamics 24 (1996), S. 651-655

add to mindlist on the mindlist

Details

ISSN: 1573-8744

Keywords: destructive sampling ; Welch's test

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The area under the curve of drug concentration over time is considered important in many toxicological, pharmacological, and medical investigations. In case that only one measurement for each experimental unit has been recorded, the area under the curve has to be estimated on the basis of the mean concentration values at the measurement times. Defining an estimator by using a linear combination of these mean values enables the straightforward estimation of the corresponding variance. For testing the null hypothesis of equality between two areas under the curve the use of Welch's test for nonpairwise contrasts is recommended; the previously suggested normal approximation of the test statistic is not an adequate choice since it exceeds the nominal α-level; this is illustrated by simulation studies.