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  • 1
    Electronic Resource
    Electronic Resource
    EFFECT OF ANTIMITOTIC DRUGS ON THE INTRAAXONAL TRANSPORT OF NEUROTRANSMITTERS IN RAT ADRENERGIC AND CHOLINERGIC NERVES (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 253 (1975), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1975.tb19224.x
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid transport of acetylcholine in rat sciatic nerve proximal and distal to a lesion (1974)
    Springer
    Journal of neural transmission 35 (1974), S. 1-11 
    Details
    ISSN: 1435-1463
    Keywords: Motor neurons ; nerve crush ; rapid intra-axonal ACh transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Changes in distribution of acetylcholine (ACh) along the length of the sciatic nerve of the rat have been studied up to 24 hours after axotomy produced usually by crushing but sometimes by cutting or ligating the nerves. The ACh was extracted with trichloracetic acid from 5 mm lengths of nerve cut relative to the lesion and estimated by bio-assay techniques. 2. Axotomy usually produced an increase in the ACh content in the 5 mm on either side of the lesion within 1–2 minutes of operation. Subsequently there was a continued marked increase in ACh content in the 5 mmproximal to the lesion up to nearly three times the control level by 12 hours, with no further increase by 24 hours. In the 5 mmdistal to the lesion there was a further slight increase up to 60% above control by 6 hours with a subsequent decline to about the control level by 24 hours. In the more distal parts of the nerve (i.e. 5–20 mm distal to the lesion) there was a decline in ACh content of about 20% by 6–12 hours after operation. The three types of axotomy produced similar changes. 3. The initial small increase of ACh on both sides of the lesion was probably due to local synthesis of ACh, as previously described by other authors. It is suggested that the marked proximal increase in ACh was due to interruption of a proximo-distal transport of ACh and that the small decline in the more distal parts of the nerve was due to continued transport of ACh out of that segment of the nerve following operation; the size of this decline has been taken as an estimate of the proportion of axonal ACh which is rapidly transportable (20% of the total). The rate of transport of this fraction of the axonal ACh has been estimated as about 5 mm/hour. The rest of the axonal ACh is thought to be either stationary or moving slowly with bulk proximo-distal movement of the axoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245331
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of chronic nicotine and withdrawal on intra-axonal transport of acetylcholine and related enzymes in sciatic nerve of the rat (1980)
    Springer
    Journal of neural transmission 47 (1980), S. 243-251 
    Details
    ISSN: 1435-1463
    Keywords: Cholinergic substances ; chronic nicotine ; withdrawal ; oral administration ; rat sciatic ; intra-axonal transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The content of acetylcholine (ACh) and activities of the cholinergic enzymes choline acetyltransferase (CAT) and ACh-esterase (AChE) were studied in intact and crushed rat sciatic nerve afterchronic nicotine administration andwithdrawal 2 days before the final experiment. Nicotine was given in the drinking water during 8–10 weeks and the final dose reached was about 8 mg/kg/day, i.e. equivalent to that of the heavy cigarette smoker. In thechronic nicotine group, ACh levels and AChE activity of uncrushed nerve were significantly decreased as compared to the controls. The accumulation of ACh and AChE proximal to a single crush was also somewhat decreased, but significant only for AChE at 18 hours postoperatively. Afterwithdrawal of nicotine for 2 days the ACh content of both uncrushed and 12 hours crushed nerves were further decreased, while AChE was instead increased to control (uncrushed) or even supranormal (18-hour crush) levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01247320
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison between the effect of colchicine and lumicolchicine on axonal transport in rat motor neurons (1975)
    Springer
    Journal of neural transmission 37 (1975), S. 305-311 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mitotic inhibitor colchicine (COL) and its isomer lumi-colchicine (lumi-COL) were tested on the axonal transport of acetylcholine (ACh), cholineacetyltransferase (CAT) and ACh-esterase (AChE) in rat motor nervesin vivo. COL was found to be far more effective in blocking axonal transport of all 3 substances than was an equimolar concentration (0.1 M) of lumi-COL, when injected into the sciatic nerve. Since COL and lumi-COL have similar properties as regards binding to cellular membranes, but differ markedly in their binding capacity to microtubule protein, the results give strong support for the theory that microtubules are essential for intra-axonal transport in mammalian nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01258657
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    Paper (German National Licenses)
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