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  • 1
    Electronic Resource
    Electronic Resource
    Hyperplasia of dermal microvascular pericytes in scleroderma (2004)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 31 (2004), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Pericytes (PCs) are smooth muscle-like mural cells of capillaries and venules, which can synthesize matrix components and fibroblast-activating cytokines, and are thus potential mediators of pathological changes in scleroderma. In this study, alterations in microvessels were quantitatively imaged, taking PC into account for the first time.Methods:  Skin biopsies from systemic (12) and localized (14) scleroderma forms as well as age-, sex-, and body location-matched controls were examined with respect to capillary and venular densities as well as endothelial cell (EC) and PC counts using a newly developed (in respect of PC and EC) indirect collagen IV immunostaining-based method.Results:  Hyperplasia of the PC that doubled the microvascular PC density was the most conspicuous characteristic. In the capillaries of the upper dermal plexus of the periphery of the sclerotic zones, median ratios of PC : EC were 0.23 (controls 0.10) or 0.18 (controls 0.11) in systemic or localized scleroderma, respectively. Furthermore, an increase in capillary density in the upper dermal plexus could be demonstrated in the marginal zones of both types of disease.Conclusions:  The observed PC increase in the peripheral zones of active disease supports the hypothesis of a vascular pathogenesis of scleroderma and directs the focus to microvascular PC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2004.00203.x
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  • 2
    Electronic Resource
    Electronic Resource
    Human dermal pericytes express 3G5 ganglioside – A new approach for microvessel histology in the skin (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 28 (2001), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Pericytes cover the abluminal surface of microvessels and play an important role in capillary regulation and pathology. Studies on pericytes have been hindered by the lack of specific markers with which to facilitate microscopic identification of this cell type. Expression of the cell surface 3G5 ganglioside antigen has been reported in cultured retinal and cardiac pericytes. The objective of this study was to determine the usefulness of monoclonal antibody 3G5 as a pericyte marker in human skin.Methods: Cryosections of 21 skin biopsies were examined by direct fluorescence technique with anti-3G5, anti-von Willebrand factor, anti-α-smooth muscle actin or DNA fluorochrome.Results: In human dermis, 3G5 expression is limited to pericytes discriminating this cell type from all other cells including smooth muscle cells, myofibroblasts and myoepithelial cells. We found a pericyte: endothelial cell ratio of 1:12.4 (±7.1), and a difference of α-smooth muscle actin expression between the subpapillary plexus and the microvessels of the Stratum reticulare.Conclusions: 3G5 mAB is an excellent and so far the only reported tool for identification of dermal pericytes by fluorescent light microscopy. Moreover, this is the first report of the application of 3G5 technique to the microvasculature in tissue sections at the light microscopic level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2001.028004206.x
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  • 3
    Electronic Resource
    Electronic Resource
    The NO release test as a functional reference standard for laser Doppler fluxmetry in cutaneous microangiology (2001)
    Copenhagen : Munksgaard International Publishers
    Skin research and technology 7 (2001), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: The application of one-dimensional laser Doppler fluxmetry (LDF) to clinical research is widespread. Large intra- and interindividual fluctuations in perfusion impede the objective evaluation of studies and hinder a standardised reproducibility. Attempts are made to minimise these biological fluctuations of the measured values by means of functional tests, standardised measuring conditions and large study populations. An intraindividual fixed standard that also facilitates interindividual comparability as a reference parameter would be desirable.Methods: By applying a nitric oxide (NO) release cream, a maximal vasodilatation is produced in a circumscribed skin area and optically registered by means of LDF. An LDF quotient is defined as a measure of the reproducibility. A total of 123 test subjects with dermatological diseases were measured at intervals of 60 min on the volar underarm on clinically normal skin with and without NO release cream.Results: The LDF quotient of the NO release test represents a stable, readily reproducible individual parameter and is appropriate as a reference standard for resting flux measurements. Therefore, we define an LDF factor that includes the maximal vasodilatation as a specific assessment characteristic and thus allows a more powerful, functionally oriented assessment of the individual measurements.Conclusion: The NO release test is appropriate as a reference standard for laser Doppler fluxmetry and realises a high reproducibility of individual measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0846.2001.70306.x
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  • 4
    Electronic Resource
    Electronic Resource
    Kongenitale melanozytäre Nävi (1999)
    Springer
    Der Hautarzt 50 (1999), S. 779-784 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Kongenitaler Nävuszellnävus ; Naevus pigmentosus congenitalis ; Malignes Melanom ; Neurokutane Melanose ; Dermabrasion ; Key words Congenital nevocellular nevus ; Congenital pigmented nevus ; Malignant melanoma ; Neurocutaneous melanosis ; Dermabrasion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Congenital melanocytic nevi are benign skin tumours with a population-based prevalence of 1–6%. They run an increased life-time risk of transformation into malignant melanoma. Additionally, they can be associated with an involvement of the leptomeninges (neurocutaneous melanosis), and may cause considerable cosmetic and psychic problems. In contrast to the past, the risk of congenital melanocytic nevi developing into melanoma is now regarded as well-established. Thus, excision is recommended whenever possible. Large lesions which do not allow complete excision should be treated by dermabrasion within the first weeks of life.
    Notes: Zusammenfassung Kongenitale melanozytäre Nävi sind gutartige, bei ca. 1–6% aller Menschen auftretende Tumoren der Haut. Sie bergen das Risiko einer Entartung zum malignen Melanom in sich, können mit einem Befall der weichen Hirnhäute vergesellschaftet sein (neurokutane Melanose) und stellen für die Betroffenen z. T. ein beachtliches kosmetisches und psychisches Problem dar. Das Entartungspotential kongenitaler Nävuszellnävi wird heute, im Gegensatz zu früheren Auffassungen, als relevant angesehen. Somit ist eine operative Entfernung grundsätzlich empfehlenswert. Große, nicht komplett exzidierbare Läsionen sollten schon in den ersten Lebenswochen durch Dermabrasion behandelt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050984
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