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  • 1
    Electronic Resource
    Electronic Resource
    Serotonin-Specific Drugs for Anxiety and Depressive Disorders (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 41 (1990), S. 437-446 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.41.020190.002253
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serotonin function in anxiety (1987)
    Springer
    Psychopharmacology 92 (1987), S. 14-24 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; MCPP ; Cortisol ; Prolactin ; Growth hormone ; Anxiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the role of serotonin function in the development of panic anxiety, the behavioral and biochemical responses to the serotonin receptor agonist, m-chlorophenylpiperazine (MCPP) was examined in healthy subjects and agoraphobic and panic disorder patients. MCPP had anxiogenic effects in both the healthy subjects and patients. Panic attacks meeting DSM-III criteria occurred following MCPP in 12 of 23 patients and 6 of 19 healthy subjects (NS) and other ratings of anxiety also did not distinguish the two groups. MCPP resulted in significant but similar increases in cortisol, prolactin, and growth hormone in the healthy subjects and patients. The results of this investigation suggest that serotonin neuronal dysfunction may not be of etiologic significance in most panic disorder patients. However, the observed anxiogenic properties of MCPP suggest that additional studies of the role of serotonin systems in the pathophysiology of human anxiety disorders are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215473
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects (1987)
    Springer
    Psychopharmacology 92 (1987), S. 431-437 
    Details
    ISSN: 1432-2072
    Keywords: Reserpine ; Desipramine ; Antidepressants ; Refractory depression ; MHPG ; HVA ; 5-HIAA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Early studies showed dramatic improvement in some depressed patients when a brief course of parenteral reserpine was added to ineffective tricyclic antidepressant (TCA) treatment. We treated eight patients with DSM-III melancholic major depression with desipramine (DMI)≥2.5 mg/kg/day (plasma levels〉125 ng/ml) for at least 4 weeks. All patients failed to respond and received reserpine 5 mg IM b.i.d. over 2 days, in seven cases as a placebo-controlled, double-blind trial. One patient had dramatic resolution of depressive and psychotic symptoms within 48 h, but relapsed within 2 weeks; two other patients had transient hypomanic symptoms. Depression ratings did not significantly change for the sample as a whole, but plasma and cerebrospinal fluid (CSF) levels of 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) decreased and CSF levels of homovanillic acid (HVA) and 5-hydroxy-indoleacetic acid (5-HIAA) increased. Despite robust effects on central monoamine metabolism, reserpine augmentation appears insufficiently effective for routine use in managing refractory depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176473
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of yohimbine in obsessive compulsive disorder (1987)
    Springer
    Psychopharmacology 93 (1987), S. 308-313 
    Details
    ISSN: 1432-2072
    Keywords: Yohimbine ; Obsessive compulsive disorder ; MHPG ; Cortisol ; Norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The α2-adrenergic receptor antagonist yohimbine was administered to 12 drug-free patients with obsessive compulsive disorder (OCD) and to 12 healthy subjects. Changes in behavior, cardiovascular symptoms, and in plasma levels of cortisol and the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), were assessed. Yohimbine had no significant effect on OCD symptoms. The OCD patients did not differ from healthy controls in their behavioral and MHPG response to yohimbine. In contrast to healthy subjects, OCD patients, like previous reports of depressed and panic disorders patients, had an increased cortisol response to yohimbine. These data suggest it is unlikely that abnormal noradrenergic function plays a primary role in the pathogenesis of OCD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187248
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Lymphocyte β-adrenergic receptor binding in panic disorder (1988)
    Springer
    Psychopharmacology 94 (1988), S. 24-28 
    Details
    ISSN: 1432-2072
    Keywords: β-Adrenergic receptors ; Anxiety ; Panic disorder ; Lymphocytes ; Noradrenergic dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N=4) or agoraphobia with panic attacks (N=17) and age- and sex-matched healthy subjects (N=22). The patients showed a significantly lower number of β-adrenergic receptor binding sites and a significantly higher affinity of binding than healthy subjects. A past or present history of major depression in the patients did not alter these findings. These results are consistent with a growing body of knowledge implicating noradrenergic dysfunction in the pathophysiology of panic anxiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735875
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    Paper (German National Licenses)
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