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  • 1
    Electronic Resource
    Electronic Resource
    Superfused mini-pig skin. A new method for studying the interaction of drugs with prostaglandin biosynthesis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb15591.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A model for studying the anti-prostaglandin activity of drugs in human skin (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb15594.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The emergence of oral and topical retinoids was a major advance in the clinical management of acne vulgaris. However, the benefits of these agents were somewhat limited by the degree of side effects caused by these drugs. Over the last 15 years, researchers have sought compounds that can provide the manifold therapeutic benefits obtained with tretinoin and isotretinoin while minimizing the potential for irritation and other unwanted effects. Adapalene, a naphthoic-acid derivative, is one result of this search, and it serves as an example of rational drug development: the formulation of a novel substance with specific pharmacological properties and clinical objectives in mind. These goals included enhancing stability, enhancing anti-inflammatory effects, maintaining effectiveness and minimizing cutaneous irritation. This paper reviews the history of the development of adapalene, its unique physical and biochemical properties, and the pharmacological studies that demonstrate a wide range of retinoid-receptor, genetic and anti-inflammatory effects, all of which contribute to the therapeutic efficacy and improved tolerability of adapalene observed in the clinical use of this agent for the treatment of acne.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0926-9959.2001.00006.x
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  • 4
    Electronic Resource
    Electronic Resource
    A novel in vitro model for the study of human keratinocyte/leucocyte interactions under autologous conditions (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Keratinocyte/leucocyte interactions have become an area of intense investigations in the last decade. However, few convenient in vitro models are available at present. We have therefore designed a novel in vitro system for autologous human keratinocyte/leucocyte co-culture. Non-invasive epidermal cell sampling was achieved by using outer root sheath cells from hair follicles. After one passage, pure keratinocyte cultures (no Langerhans cells or melanocytes) were obtained. Co-culture experiments were performed on a Transwell system: keratinocytes were grown on the porous cupula, and then laid on to wells containing leucocytes. Alternatively, leucocytes can be added to the cupula when contact interactions between the two cell types are to be investigated.Using this system, we demonstrated that Phaesolus vulgaris phytohaemagglutinin-activated T lymphocytes (with 10% monocytes) in the lower compartment induced intercellular adhesion molecule 1 (ICAM-1) and HLA-DR expression, and inhibited methyl-3H-thymidine incorporation in normal human autologous keratinocytes cultured on the cupula. These changes were mediated by soluble factors (no cell contacts between keratinocytes and leucocytes), and required lymphocyte activation.This is the first direct in vitro evidence for leucocyte-induced ICAM-1 and HLA-DR expression on keratinocytes. This system is a potential tool for the study of keratinocyte/leucocyte interactions. The technique is easy to perform, keratinocyte and leucocyte responses can be assessed separately (proliferation, surface antigen expression), experiments within a given donor can easily be reproduced, and this model lends itself to a vast range of different experimental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb00478.x
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  • 5
    Electronic Resource
    Electronic Resource
    A cellulose ester film as an inert vehicle for skin pharmacological studies (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb15597.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Is prostacyclin a circulating anti-coagulant? (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 706-706 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LUNG tissue from numerous animal species, including man, has been shown to be capable of synthesising and releasing a variety of prostaglandins (Piper & Vane Ann. N.Y. Acad. Sci. 180, 363; 1971). Furthermore, metabolic transformation in the lung rapidly inactivates these prostaglandins ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/273706a0
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The rhino mouse model: the effects of topically applied all-trans retinoic acid and CD271 on the fine structure of the epidermis and utricle wall of pseudocomedones (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 100-107 
    Details
    ISSN: 1432-069X
    Keywords: Rhino mouse skin ; All-trans retinoic acid ; CD271 ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histological and ultrastructural effects following 3 weeks' topical treatment with two agents (all-trans retinoic acid and a new synthetic retinoid-like substance, CD271) were evaluated on the epidermis and the epithelial wall of the pseudocomedones in rhino mouse skin. The comedolytic effects of these drugs were similar, and consisted of a reduction of the utricular diameter, with normalization of follicular units. Morphological examinations revealed a hyperplastic response with an increase in the number of cell layers of both epidermis and follicular epithelium, and modifications in keratinocyte differentiation. Ultrastructural changes in the epidermis and epithelial wall were observed mainly in the granular and horny layers, with increased desquamation, and a decrease in the cohesiveness of corneocytes. During the first week of treatment, some cutaneous toxic effects were noticed, but they normalized within two weeks. On the other hand, a fine granular material persisted in the intercellular spaces. It is confirmed that the skin of the rhino mouse is a good model for the evaluation of the comedolytic effects of drugs. Moreover, it reveals the specific effects of retinoids on epidermal differentiation. We have demonstrated that topically applied CD271 induces modifications similar to those obtained with all-trans retinoic acid. It is thus concluded that CD271 is a potentially effective anti-acne agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371617
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  • 8
    Electronic Resource
    Electronic Resource
    In vitro andin vivo antiinflammatory activities of C10 substituted anthralin derivatives (1987)
    Springer
    Inflammation research 21 (1987), S. 247-249 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions In model systems where anthralin and butanthrone have a high anti-proliferative activity, e.g., inhibition of keratinocyte metabolism in culture or inhibition of ornithine decarboxylase inductionin vivo, CD 003 is inactive. However, in the skin disease psoriasis there is both an inflammatory as well as a differentiation/proliferation component, and consequently we have evaluated anthralin and butanthrone for their potentialin vivo antiinflammatory activities. In addition, we have compared a new analogue, substituted at C10, with these two compound. Our results support the belief that modification of the anthralin structure can result in the formation of less toxic, less irritant and less staining analogues, which maintain or significantly improve upon the topical antiinflammatory properties of anthralin. The possibility that such analogues will be of use in the treatment of skin diseases with a major inflammatory component is at present being investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966480
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  • 9
    Electronic Resource
    Electronic Resource
    Antiinflammatory aspects of systemic and topically applied retinoids (1987)
    Springer
    Inflammation research 21 (1987), S. 238-240 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions Evidence is presented that retinoids have topical and systemic antiinflammatory actionsin vivo. This degree of antiinflammatory activity, as assessed in different model systems is often similar to that observed for standard reference antiinflammatory agents of both the non steroidal or corticosteroidal type. These new classes of polycyclic substances not only share the ability of retinoids to modulate cellular differentiation, but in addition have a general antiinflammatory action. The mechanism of this activity is at present unknown but under investigation in our laboratories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966477
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of antiinflammatory agents on edema and DNA synthesis induced by 12-O-tetradecanoylphorbol-13-acetate in the guinea pig (1987)
    Springer
    Inflammation research 21 (1987), S. 290-292 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammation and hyperplasia are frequently associated in skin diseases. In order to verify this relationship, we studied the antagonistic effect of different classes of antiinflammatory agents on the inflammatory and hyperplasiogenic responses elicited by one topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the ear of the guinea-pig. Edema and DNA synthesis were chosen as relevant parameters. All antiinflammatory agents tested significantly inhibited DNA synthesis induced by TPA. Moreover, all compounds except quinacrine and phenylbutazone also inhibited edema formation. In conclusion, our results demonstrate that while edema and hyperplasia are frequently associated, this is not always the case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966494
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