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  • 1
    Electronic Resource
    Electronic Resource
    Menstrual regulation by intramuscular injections of 16-phenoxy-tetranor PGE2 methyl sulfonylamide or vacuum aspiration. A randomized multicentre study (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A multicentre trial was conducted to compare the efficacy and side-effects of an intramuscularly administered PGE2 analogue and vacuum aspiration in women with a delay of up to 21 days in the expected onset of menses. A total of 473 such women were randomly allocated to treatment with either 16-phenoxy-W-17, 18, 19, 20-tetranor PGE2 methyl sulfonylamide (three intramuscular injections of 0.5 mg at 3-h intervals) or vacuum aspiration, and the outcome of therapy assessed 1, 2 and 6–8 weeks later. Retrospective analysis of hCG levels indicated that 419 (88.6%) women had been pregnant at the time of treatment. With few exceptions, administration of the PGE2 analogue induced vaginal bleeding in both pregnant and non-pregnant women but the duration and subjectively perceived amount of bleeding were greater than after vacuum aspiration. Both treatments were equally effective. In pregnant women the overall frequency of complete abortion was 91% for prostaglandin treatment and 94% for vacuum aspiration. If non-pregnant women were included, the respective success rates (i.e. percentages of women not pregnant 2 weeks after treatment) were 92% and 95%. Gastrointestinal side-effects and lower abdominal pain requiring intramuscular analgesia were more common after prostaglandin therapy than following vacuum aspiration in both pregnant and non-pregnant women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb02268.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE ROLE OF FETAL DEATH IN THE PROCESS OF THERAPEUTIC ABORTION INDUCED BY INTRA-AMNIOTIC INJECTION OF HYPERTONIC SALINE (1970)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 77 (1970), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In 21 pregnancies in which therapeutic abortion was induced by intra-amniotic hypertonic saline injection in the second trimester of the pregnancy, the moment of fetal death and the maximum hypertonicity of the amniotic fluid were established. Comparing these with each other and with the onset and the duration of the abortion process, a close correlation could be found only between the time till death of the fetus and the hypertonicity of the amniotic fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1970.tb03478.x
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  • 3
    Electronic Resource
    Electronic Resource
    ''Menstrual induction'' with sulproston
    Amsterdam : Elsevier
    Prostaglandins 24 (1982), S. 657-665 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(82)90035-1
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  • 4
    Electronic Resource
    Electronic Resource
    Microsomal lipid peroxidation in human pregnant uterus and placenta
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 79 (1977), S. 843-851 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(77)91188-3
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  • 5
    Electronic Resource
    Electronic Resource
    Increased lysosomal fragility in the human uterine cervix following estrogen therapy (1985)
    Springer
    Archives of gynecology and obstetrics 236 (1985), S. 131-133 
    Details
    ISSN: 1432-0711
    Keywords: Lysosomes ; Uterine cervix ; Cervical ripening ; Exposure to oestrogens ; Glycosaminoglycan turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vitro stability of the lysosomal membrane complex was studied in non-pregnant human uterine cervices. The oestrogen therapy caused markedly enhanced lability of the lysosomal membrane complex as evidenced by higher activity of the “marker” enzyme when the preparations were challenged by mechanical or detergent stress. Oestradiol-17β might be implicated in altering the metabolism of the proteoglycan complex which may result in the “ripening” of the pregnant cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02133955
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  • 6
    Electronic Resource
    Electronic Resource
    Serum-Bilirubinwerte und Steroidausscheidung bei mit 3α,20α- und 3α,20β-Pregnandiol belasteten Neugeborenen (1970)
    Springer
    Archives of gynecology and obstetrics 209 (1970), S. 58-70 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Ausscheidungen von Pregnandiol, 17-Ketosteroide und von Oestrogenen im Harn sowie die Serum-Bilirubinwerte gesunder, reifer, mit der Milch ihrer Mütter ernährter, männlicher Neugeborener wurden täglich bestimmt. Am 6. Lebenstage erfolgten Belastungen per os mit 2, 5 und 10 mg 3α,20β-Pregnandiol und 3α,20α-Pregnandiol. Aufgrund der Belastung zeigte sich ein Anstieg der Pregnandiol- und Oestrogenausscheidung der Neugeborenen und bei größeren Gaben von Pregnandiol gleichzeitig auch eine Erhöhung der Serum-Bilirubinwerte. Die niedrigeren Gaben bewirkten ein langsameres Absinken der Bilirubinwerte. Die Wirkungen des 3α,20α-Pregnandiols auf die Steroidausscheidung und den Bilirubinspiegel sind zumindest ebenso intensiv wie die des 3α,20β-Pregnandiols.
    Notes: Summary The excretions of pregnanediol, 17-ketosteroids and of estrogens in the urine as well as rates of serum bilirubin of healthy, mature, breastfed male newborns were determined every day. On the 6th day of life the newborns received 2, 5 or 10 mg, respect., of 3α,20β-pregnanediol and 3α,20α-pregnanediol by mouth. Consequently there was a rise of excretion of pregnanediol and of estrogen noted. Higher dosages of preganediol caused an elevation of serum bilirubin at the same time. The smaller dosages were causing a slower decrease of the bilirubin values. The effects of 3α,20α-pregnanediol on the excretion of steroids and on the level of bilirubin are at least as intensive as the effect of 3α,20β-pregnanediol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00673653
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  • 7
    Electronic Resource
    Electronic Resource
    Das Verhalten der Steroidausscheidung und des Serum-Bilirubinspiegels bei Neugeborenen nach C19-Steroid-Belastung (1970)
    Springer
    Archives of gynecology and obstetrics 209 (1970), S. 50-57 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sechs gesunde, männliche Neugeborene wurden am 6. Lebenstag einmalig mit 2, 5 oder 10 mg Androstendion per os belastet. Auf solche Belastungen blieben die Pregnandiol- und 17-Ketosteroidausscheidung unverändert, während die Oestrogenausscheidung bei sämtlichen Probanden erhöht war. Die Belastung mit Androstendion zeigte in allen Fällen einen Anstieg bzw. einen verzögerten Abfall des Serum-Bilirubinspiegels. Ferner erhielten zehn Neugeborene am 5.–8. Lebenstage täglich 5 mg Dehydroepiandrosteron, auch diese Belastung bewirkte eine Erhöhung der Serum-Bilirubinwerte. Die Verfasser kommen zu dem Schluß, daß C19-Steroide — ähnlich wie andere Steroide — die Glucuronsäurekonjugation und die Ausscheidung des Bilirubins hemmen, möglicherweise aufgrund der kompetitiven Verdrängung zwischen Steroiden und Bilirubin.
    Notes: Summary Six healthy male newborns received on the sixth day of life 2, 5 or 10 mg, respect. of androstendion in one dose by mouth. As a result of this charge the excretion of pregnanediol and of the 17-ketosteroids remained unchanged, whereas the excretion of estrogens was elevated in all of the tested newborns. The application of androstendion revealed in all the cases a rise or a delayed drop, respectively of the level of serum bilirubin. Additional 10 newborn babies received 5 mg dehydroepiandrosteron daily between the 5th and the 8th day of life. This charge too was causing an elevation of the rates of serum bilriubin. The authors conclude that C19 steroids-similar to other steroids — are inhibiting the conjugation of glucuronic acid and the excretion of bilirubin, possibly due to a competitive displacement between the steroids and bilirubin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00673652
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  • 8
    Electronic Resource
    Electronic Resource
    Newcastle disease outbreaks in recent years in Western Europe were caused by an old (VI) and a novel genotype (VII) (1998)
    Springer
    Archives of virology 143 (1998), S. 49-64 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Newcastle disease virus (NDV) strains, isolated from outbreaks during epizootics between 1992 and 1996 in Western European countries, were compared by restriction enzyme cleavage site mapping of the fusion (F) protein gene between nucleotides 334 and 1682 and by sequence analysis between nucleotides 47 and 435. Both methods revealed that NDV strains responsible for these epizootics belong to two distinct genotypes. Strains derived from sporadic cases in Denmark, Sweden, Switzerland and Austria were classified into genotype VI [6], the same group which caused outbreaks in the Middle East and Greece in the late 1960’s and in Hungary in the early 1980’s. In contrast, viruses that caused epizootics in Germany, Belgium, The Netherlands, Spain and Italy could be classified into a novel genotype (provisionally termed VII), hitherto undetected in Europe. It is possible that the genotype VII viruses originated in the Far East because they showed a high genetic similarity (97%) to NDV strains isolated from Indonesia in the late 1980’s.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050267
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  • 9
    Electronic Resource
    Electronic Resource
    Identification and grouping of Newcastle disease virus strains by restriction site analysis of a region from the F gene (1996)
    Springer
    Archives of virology 141 (1996), S. 243-261 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 75% region of the F gene (between nucleotides 334 and 1682) of Newcastle disease virus (NDV) RNA was amplified by reverse transcription-polymerase chain reaction (RT-PCR). PCR products were cleaved by three restriction endonucleases and the positions of thirty cleavage sites were mapped in more than 200 NDV strains. Restriction site analysis established six major groups of NDV isolates and unique fingerprints of vaccine strains. Group I comprised lentogenic strains isolated mainly from waterfowl with some from chickens. “Old” (prior to 1960s) North American isolates of varying virulence including lentogenic and mesogenic vaccine strains belonged to group II. Group III included two early isolates from the Far East. Early European strains (Herts 33 and Italien) of the first panzootic (starting in the late 1920s) and their descendants with some modifications were placed into group IV. NDV strains isolated during the second panzootic of chickens (starting in the early 1960s) were classified into two groups. Group V included strains originating in imported psittacines and in epizootics of chickens at the early 1970s. Group VI comprised strains from the Middle East in the late 1960s and later isolates from Asia and Europe. Pigeon paramyxovirus-1 strains that were responsible for the third panzootic formed a distinct subgroup in group VI. Our grouping of NDV strains has confirmed group differences established by monoclonal antibodies. It is concluded that restriction site analysis of F gene PCR amplicons is a relatively fast, simple and reliable method for the differentiation and identification of NDV strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01718397
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  • 10
    Electronic Resource
    Electronic Resource
    Two novel genetic groups (VIIb and VIII) responsible for recent Newcastle disease outbreaks in Southern Africa, one (VIIb) of which reached Southern Europe (1999)
    Springer
    Archives of virology 144 (1999), S. 2087-2099 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  34 strains of Newcastle disease virus (NDV) isolated during epizootics in the Republic of South Africa and in Mozambique between 1990 and 1995, and in Bulgaria and Turkey in 1995–1997 were identified by restriction enzyme and partial sequence analysis of the fusion (F) protein gene. The majority of isolates in southern Africa and those from Bulgaria and Turkey were placed into a novel group which has been termed VIIb. Group VIIb is part of a larger genetic cluster (VII) that also includes NDV strains from the Far East and some western European countries (VIIa). The genetic distance of 7–8, 5% between genotype VIIa and VIIb viruses excludes the existence of a direct epidemiological link between recent southern African epizootics and outbreaks in either western Europe in the 1990’s or those of the Far East. Another hitherto unrecorded genotype (VIII) was also found in South Africa with descendants of putative ancestral members isolated in the 1960’s. The genetic distance of recent group VIII strains from the major epizootic genotype (VIIb) is over 11%, therefore outbreaks caused by them were epidemiologically unrelated. Genotype VIII viruses must have been maintained in South Africa by endemic infections during the past decades while group VIIb appears to be introduced more recently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050050624
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