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  • 1
    Electronic Resource
    Electronic Resource
    Biosynthesis of Angiotensinogen and Angiotensins by Brain Cells in Primary Culture (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 51 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: This study focuses on the ability of primary rat brain cells in culture to synthesize angiotensinogen, angio-tensin I, and angiotensin II. HPLC in combination with radioimmunoassay was used to characterize these compounds. Following incubation with 3H-labeled isoleucine, radioactively labeled angiotensinogen with an approximate molecular weight of 25,000 was identified in both glial and neuronal cells. Other molecular weight forms of angiotensinogen with molecular weights of about 300 and 160,000 were present in both cell types. In addition to angiotensinogen, radioactively labeled angiotensin I and angiotensin II were also synthesized by neuronal and glial cells. These results suggest that glial and neuronal cells can synthesize angiotensinogen, angiotensin I, and angiotensin II in a similar manner shown for the peripheral renin angiotensin system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb01052.x
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of Angiotensin Peptides by Neuronal and Glial Cultures from Rat Brain (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 52 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The degradation pattern and rate of [Ile5]-Angio-tensin (Ang) I, II, and III were studied in neuron-enriched and glia-enriched cells in primary cultures from rat brain. Metabolites were separated by HPLC, and their identities were evaluated by comparison of their retention times with those of synthetic Ang peptide fragments and by analysis of their amino acid composition. Major metabolites were identified as des-Asp1-[Ile5]-Ang I, des-Asp1-[Ile5]-Ang II, [Ile5]-Ang II (3–8) hexapeptide, [Ile5]-Ang II (4–8) pentapeptide, and [Ile5]-Ang II (5–8) tetrapeptide. Glia-enriched cells degraded [Ile5]-Ang I and [Ile5]-Ang III significantly faster than neuron-enriched cells, whereas no difference between the two types of cells was found in the degradation rate of [Ile5]-Ang II. Although the half-lives of [Ile5]-Ang I and [Ile5]-Ang III in neuron-enriched cells from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were not significantly different, neuron-enriched cultures from WKY rats metabolized [Ile5]-Ang II about 2.6 times faster than neuron-enriched cells derived from SHR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1989.tb02534.x
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  • 3
    Electronic Resource
    Electronic Resource
    Tryptase concentration in skin blister fluid from patients with bullous skin conditions (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 771-773 
    Details
    ISSN: 1432-069X
    Keywords: Key words Tryptase ; Mast cells ; Allergic contact ; dermatitis ; Bullous pemphigoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050139
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  • 4
    Electronic Resource
    Electronic Resource
    Vergleich verschiedener Algorithmen zur Berechnung von Varianzkomponentenmodellen bei unvollständigen Daten (2000)
    Springer
    Allgemeines statistisches Archiv 84 (2000), S. 389-416 
    Details
    ISSN: 1614-0176
    Keywords: Keywords ML, REML, iterated MINQUE, Fisher-Scoring, EM-algorithm, simulation study, generalized repeated measure models, incomplete data.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Description / Table of Contents: Summary: In a simulation study we compare the three well known variance component estimators (MINQUE, iterated MINQUE/REML and ML) as well as a ‘naive’ estimator using a simple repeated measure model (two fixed effects and a compound symmetry structure of the covariance matrix). The distribution of the residuals is varied (normally, symmetrically ans skewed) as well as the quotient of the two variance components. Also several structures of unbalance/incompleteness are simulated corresponding to different methods of data sampling. Two different estimates of start values are used. If the residuals are normally or symmetrically distributed the differences between the considered estimators are relatively small. If the residuals are skewed, the differences between the estimators become obvious. It seems that estimation of the variance components does not essentially affect the estimation of fixed effects.
    Notes: Zusammenfassung: In einer Simulationsstudie werden an einem einfachen repeated measure model mit unvollständigen Daten (zwei feste Effekte und compound symmetry als Kovarianzstruktur) die drei wesentlichen Zugänge (MINQUE, iterierte MINQUE/REML und ML) sowie ein “naiver” Schätzer verglichen. Dabei wird die Verteilung der Residuen (normal, symmetrisch, schief verteilt) und der Quotient aus den beiden Varianzkomponenten variiert, verschiedene Anfangsschätzungen genutzt und verschiedene Strukturen der Unbalanciertheit/Unvollständigkeit der Daten simuliert, die verschiedenen Methoden der Stichprobenerhebung entsprechen. Während im Fall normal oder symmetrisch verteilter Residuen die Unterschiede zwischen den verschiedenen Schätzern relativ gering sind, ist im Fall schief verteilter Residuen eine deutliche Differenzierung zwischen den Verfahren zu erkennen, die jedoch keine wesentlichen Auswirkungen auf die Schätzung der festen Effekte hat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101820000040
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  • 5
    Electronic Resource
    Electronic Resource
    Einsatz von Strahlkondensatoren in einem Blow-down-System (1994)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 871-873 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330660622
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  • 6
    Electronic Resource
    Electronic Resource
    Direktkondensation notentspannter Dampf/Gas-Gemische in einem StrahlkondensatorPoster auf dem Jahrestreffen der Verfahrens-Ingenieure, 25. bis 27. Sept. 1991 in Köln. (1992)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 64 (1992), S. 183-184 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330640217
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  • 7
    Electronic Resource
    Electronic Resource
    Synthese Cyan-substituierter Heterocyclen mit Tetraethyl-ammoniumcyanid (1981)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1981 (1981), S. 333-341 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis of Cyano-Substituted Heterocycles by Means of Tetraethylammonium CyanideChloropyrimidines 2, 3 and Chlorquinazolines 9, 10, after conversion into trimethylammonio derivatives 4, 5, 11, 12, react with tetraethylammonium cyanide 1a under very mild conditions to give pyrimidine carbonitriles 6, 7 and quinazoline carbonitriles 13, 14. Direct synthesis of quinoxaline carbonitriles 19 is possible by reaction of chloroquinoxalines 15, 18 with 1a.
    Notes: Die Chlorpyrimidine 2, 3 und Chlorchinazoline 9, 10 können nach Überführung in die Trimethyl-ammonioderivate 4, 5, 11, 12 mit Tetraethylammoniumcyanid (1a) unter sehr milden Bedingungen zu den Pyrimidin- und Chinazolincarbonitrilen 6, 7 bzw. 13, 14 umgesetzt werden. Bei den 2-Chlorchinoxalinen 15, 18 gelingt die direkte Substitution mit 1a zu den Nitrilen 19.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198119810217
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