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Evidence for an immunocompromising effect of bovine pestivirus on bovid herpesvirus 1 vaccination (1986)

Edwards, S. ; Wood, L. ; Hewitt-Taylor, C. ; [et al.]

Springer

Veterinary research communications 10 (1986), S. 297-302

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ISSN: 1573-7446

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Five calves were given live intranasal vaccine against bovid herpesvirus 1 (BHV1) two days after intranasal inoculation of bovine pestivirus (BVDV). Another 5 were vaccinated in the absence of BVDV. Control unvaccinated groups were also maintained. All calves were challenged with virulent BHV1. The unvaccinated calves developed signs of infectious bovine rhinotracheitis (IBR) and both vaccinated groups showed a similar degree of clinical protection from IBR. Those given BVDV before vaccination shed up to 140 times more BHV1 (P〈0.01) in the nasal mucus following challenge than those which had received BHV1 vaccine alone. The epidemiological significance of this is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02213992

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