ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The renal effects of nine, 8-substituted derivatives of 3′,5′-cyclic monophosphate were studied in anesthetized mongrel dogs. Infusion of the compounds into a renal artery resulted in an increase of renal blood flow without any effect on blood pressure. Diuretic and natriuretic effects are evident with 6 of the 9 derivatives. As these 8-substituted analogues exert renal effects in a manner similar to that seen with the parent nucleotide, cyclic adenosine 3′,5′-monophosphate, they may serve as useful pharmacological agents in vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01953752
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