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  • 1
    Electronic Resource
    Electronic Resource
    DEVELOPMENTAL AND REGIONAL VARIATIONS IN NEUROTRANSMITTER-SENSITIVE ADENYLATE CYCLASE SYSTEMS IN CELL-FREE PREPARATIONS FROM RAT BRAIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Investigations have been carried out on regional and developmental variations in the properties of adenylate cyclase systems in participate preparations from rat brain. EGTA was routinely included in the assay medium to minimize differences in the state of activation of these systems resulting from variations in their exposure to endogenous Ca2+. At birth, adenylate cyclase activity was much higher in the hindbrain-medullary preparations than in comparable fractions from cerebellum, cerebral cortex or subcortex (including midbrain, corpus striatum, hypothalamus and hippocampus). Adenylate cyclase activity increased during early development in preparations from all areas of the brain. Maximal levels were reached at 14 days of age or later. These levels were not greatly altered in the young adult animal, except in the hindbrain-medullary area, where a decrease in activity was observed. Adenylate cyclase systems in cerebral cortical and subcortical preparations were activated by norepinephrine and dopamine throughout development. Serotonin also stimulated adenylate cyclase activity in these preparations from young animals but was much less effective in comparable fractions from adult rats. The response to dopamine was diminished with age in cerebral cortical preparations, but not in subcortical fractions. The responses to norepinephrine increased in both brain regions during early development. Adenylate cyclase systems in particulate preparations from the cerebellum and hindbrain-medullary areas exhibited relatively poor responses to the biogenic amines. Detailed studies of the properties of the cerebral cortical adenylate cyclase systems revealed enhancement of activity by Ca2+ and F− at all stages of development with the maximal activation at 2–3 weeks of age. The results suggest that developmental differences in hormonal sensitivity of adenylate cyclase systems from diverse areas of the brain are related to changes in the proportions of the receptor-enzyme complexes responsive to the different biogenic amines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04299.x
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  • 2
    Electronic Resource
    Electronic Resource
    An autosomal transcript in skeletal muscle with homology to dystrophin (1989)
    [s.l.] : Nature Publishing Group
    Nature 339 (1989), S. 55-58 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To isolate the full coding sequence of the dystrophin gene, cDNA clones were used to walk sequentially in an oligo(dT)-primed, fetal-muscle cDNA library14"15. When the library was screened with two contiguous Hindll DMD cDNA fragments (D1.2 and D0.6, Fig. 1) that encode the final C-terminal domain ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/339055a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    LSD as an agonist and antagonist at central dopamine receptors (1974)
    [s.l.] : Nature Publishing Group
    Nature 252 (1974), S. 588-589 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] D-LSD has also been reported to block the action of nor-adrenaline on central neurones5 and to produce stereotypy in rats6, a condition which is associated with dopaminergic hyperactivity7. Moreover, several recent reports have indicated that a number of ergot derivatives are capable of exerting ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/252588a0
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    Paper (German National Licenses)
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