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  • 1
    Electronic Resource
    Electronic Resource
    CELLULAR IMMUNITY TO HUMAN BASIC MYELIN PROTEIN IN WOMEN WITH DYSPLASIA AND CARCINOMA IN SITU OF THE CERVIX (1975)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 82 (1975), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sensitization to human myelin basic protein or encephalitogenic factor (EF), an antigen thought to be analogous to different human tumours, can be measured by the macrophage migration inhibition test (MMI). The MMI test was done on one occasion in 51 women with dysplasia and carcinoma in situ of the cervix; 20 women with non-malignant gynaecological conditions served as controls Sensitization to EF was found in 71 per cent of women with carcinoma in situ and 42 per cent of women with dysplasia. None of the controls showed sensitization. Sensitization could not be related to histological evidence of cellular infiltration within the cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1975.tb00580.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    SHORT-TERM MEMORY AND THE ALCOHOLIC BLACKOUT (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 215 (1973), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1973.tb28268.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders: Part 1 (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 5 (2000), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This article reviews the results of studies concerning particular classes of biological phenotypes that may have relevance for alcohol dependence. Broadly defined, these classes include brain neurotransmitter systems and neuroelectric potentials. Evidence is presented concerning genotypic variation in alcoholics and high-risk relatives suggesting that the etiology of alcoholism and other addictive diseases is mediated in part through suboptimal neurotransmitter functioning. Research opportunities are offered with respect to specific candidate genes that have been cloned from these neurotransmitter systems that could be most fully utilized in family-based genetic analyses. Additional evidence is offered, suggesting that characteristics of particular neuroelectric potentials (e.g. the amplitude of the P300 component of the event-related potential) may provide another dimension of potential markers that could be used to identify children at risk. Finally, methodological considerations specific to high risk studies are discussed. Among these are the need to include a plan for studying more severe cases of alcohol dependence that are relatively uncomplicated by other major psychiatric disorders. Plans for long-term follow-up of children at highest risk for developing the disorder should also be included. Multiple domains of inquiry should not be viewed as unfocused but rather as an economical means for utilizing highly characterized samples of individuals meeting rigorous research criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/13556210071234
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Imipramine and REM sleep: Cholinergic mediation in animals (1980)
    Springer
    Psychopharmacology 69 (1980), S. 5-9 
    Details
    ISSN: 1432-2072
    Keywords: Imipramine ; Sleep ; Physostigmine ; REM sleep ; Animals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date it has not been established whether the anticholinergic properties of imipramine are responsible for the drug's suppression of REM and prolongation of REM induction. A cholinesterase inhibitor, physostigmine, was administered in conjunction with imipramine to determine if these effects of imipramine were cholinergically medicated. Sleep EEG recordings were observed in rats administered either physostigmine (1.0 mg/kg), or imipramine (1.25, 2.5, or 5.0 mg/kg), alone or in combination. The results indicate that physostigmine blocks the effects of imipramine on REM latency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426514
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of l-tryptophan and ethanol on sleep parameters in the rat (1978)
    Springer
    Psychopharmacology 58 (1978), S. 229-233 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; l-Tryptophan ; Sleep ; Drug effects ; 5-HT neurons ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sleep parameters were monitored following (1) a single 2 g/kg oral dose of ethanol, (2) an oral dose of l-tryptophan (600 mg/kg), and (3) administration of both drugs simultaneously. Ethanol reduced REM and increased slow wave significantly. The effects of l-tryptophan were apparent only in the case of one parameter, REM latency. Administration of both drugs resulted in a significantly shorter REM latency than that observed for ethanol administered alone. Results are discussed in terms of possible changes in the biosynthesis of 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427384
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of acute doses of zimelidine on REM sleep in rats (1983)
    Springer
    Psychopharmacology 80 (1983), S. 214-216 
    Details
    ISSN: 1432-2072
    Keywords: Zimelidine ; Sleep EEG ; REM latency ; REM sleep ; Rats ; 5-HT uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sleep EEG (7 h) were obtained from 11 rats given 5, 10, and 20 mg/kg zimelidine, and a control dose of saline. Zimelidine significantly suppressed REM sleep, lengthened REM latency, and reduced total sleep time (TST) in a dose-dependent manner. Sleep latency was not affected except at the highest dose of zimelidine. Slow-wave sleep (SWS) was not affected at any dose. The results are discussed in terms of their implication for the use of zimelidine in the clinical treatment of depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436155
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of repeated zimelidine administration on sleep parameters in the rat (1986)
    Springer
    Psychopharmacology 88 (1986), S. 54-57 
    Details
    ISSN: 1432-2072
    Keywords: Zimelidine ; Sleep EEG ; REM latency ; REM sleep ; Rats ; 5-HT uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seven-hour sleep EEG recordings were obtained from rats (N=15) given a single acute dose, and rats (N=15) given 14 daily doses of zimelidine, 20 mg/kg IP. REM latency, REM sleep, number of REM episodes, and total sleep time were significantly affected by zimelidine administration when compared to controls, as well as to each animal's baseline sleep parameters. Sleep latency and slow-wave sleep were not significantly affected by zimelidine. The results are discussed in terms of the implications of the use of zimelidine as a clinical treatment for depression, as well as the implications for the use of REM changes as a diagnostic indicator of the efficacy of treatment with zimelidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310512
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    State-dependent Effects of Marihuana on Human Memory (1973)
    [s.l.] : Nature Publishing Group
    Nature 243 (1973), S. 241-242 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Barry and Kubena9 have shown that D9?transtetrahydro-cannabinol produces state-dependent effects in rats. In the study reported here we examined the effects of smoking marihuana on various tasks, to see whether the drug produces state-dependency in man. If Overton's hypothesis is correct, detection ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/243241a0
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Acquired preference for morphine but not d-amphetamine as a result of saccharine adulteration (1976)
    Springer
    Psychopharmacology 50 (1976), S. 309-312 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Morphine ; Drug ingestion ; Saccharine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Consumption of morphine sulfate and d-amphetamine was studied in two groups of rats. In a choice situation, preference for both drugs remained low after 46 days of drinking. In two additional groups morphine and d-amphetamine solutions were prepared with 1% saccharine. Morphine drinking was significantly increased by saccharine adulteration, whereas drinking of amphetamine solutions decreased. Addition of saccharine to morphine solutions increased drinking in more than a simple additive way. Saccharine facilitates the acquisition of drug-directed behavior. The slope of the acquisition trials for the morphine-saccharine group was significantly different from horizontal (O-slope) and significantly different from the slope found for the morphine without saccharine group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426850
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  • 10
    Electronic Resource
    Electronic Resource
    Cocaine effects on sleep parameters in the rat (1977)
    Springer
    Psychopharmacology 51 (1977), S. 125-127 
    Details
    ISSN: 1432-2072
    Keywords: Cocaine ; Stimulants ; Sleep ; Oral administration ; Encephalograph
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cocaine in 6 mg/kg doses was administered orally and intraperitoneally to rats and sleep EEG's recorded. Cocaine significantly reduced total sleep time, slow-wave sleep, and sleep latency. Rapid eye movement sleep (REM) was significantly suppressed during the first half of the sleep recording. These effects were evident by both routes of administration. The effects of cocaine on total sleep time in animals parallels that observed in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431727
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