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  • 1
    Electronic Resource
    Electronic Resource
    Formulation, Bioavailability, and Pharmacokinetics of Sustained-Release Potassium Chloride Tablets (1991)
    Springer
    Pharmaceutical research 8 (1991), S. 1313-1317 
    Details
    ISSN: 1573-904X
    Keywords: potassium chloride ; sustained-release tablets ; formulation ; in vitro evaluation ; bioavailability ; pharmacokinetics ; in vitro–in vivo evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The release of potassium chloride incorporated into hydrogenated vegetable oil and hydroxypropyl methylcellulose matrix tablets was studied in vitro. The formulations containing 20% hydrogenated vegetable oil and hydroxypropyl methylcellulose showed a sustained-release profile comparable to that of a standard commercially available sustained-release preparation, containing 8 mEq potassium chloride embedded in a wax material. The formulated and standard sustained-release potassium chloride tablets were compared to a conventional enteric-coated potassium chloride tablet in 10 healthy subjects. Mean recoveries in 24-hr urine potassium levels from four dosage forms (after subtracting normal urine potassium excretion levels) were 76 ± 32% from hydroxypropyl methylcellulose, 95 ± 22% from hydrogenated vegetable oil-incorporated matrix tablets, 91 ± 29% from commercially available sustained-release tablets, and 97 ± 13% from enteric-coated tablets. There was no significant difference (P 〉 0.05) in the time to reach maximum excretion rates among the three sustained-release tablets. No significant adverse effect was experienced with any of the preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015868232590
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 359-363 
    Details
    ISSN: 1573-904X
    Keywords: lithium ; sustained release ; pharmacokinetics ; bioavailability ; in vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The release of lithium carbonate incorporated into polymethylmethacrylate, poly vinyl chloride, hy-drogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015863204732
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Preparation and investigation of the tenoxicam/β-cyclodextrin complex (1992)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 14 (1992), S. 171-179 
    Details
    ISSN: 1573-1111
    Keywords: Tenoxicam/β-cyclodextrin complexation ; freeze-drying method ; co-grinding method ; characterization of inclusion complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A complex of tenoxicam withβ-cyclodextrin was prepared by using co-grinding and freeze drying methods. The resulting products were studied by the solubility method, ultraviolet and infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry. The dissolution behaviour of the products was also examined. The dissolution rate of the co-ground and freeze-dried products was faster than that of the pure drug and the physical mixture of drug andβ-cyclodextrin. The enhanced dissolution rate of the products might be attributed to the amorphous state, the increased wettability of the drug and the inclusion complex formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01029665
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    Paper (German National Licenses)
    Fulltext
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