ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Partial Syntheses of Cardenolides and Cardenolide Analogues. VIII. Lactone Ring-Alkylated CardenolidesBase-catalyzed alkylation of digitoxigenin (1), digitoxin (2), digoxigenin (3), and gitoxigenin-3,16-diacetate (4) with allyl bromide, allyl chloride or n-propyl bromide in DMF resulted in the formation of the 22-allyl-, 21ξ,22-diallyl-, 22-propyl-, and 21ξ,22-dipropyl-derivatives 5-14, respectively.The determination of the molecular biological activity of the derivatives yielded valuable information.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19833250409
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