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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effects of the steroid Methylprednisolone on the induction of suppressor lymphocytes in human mixed lymphocyte cultures (MLC) have been examined. Concentrations of methylprednisolone (MP) sufficient to inhibit both the cellular proliferation and the generation of cytotoxic lymphocytes in MLC appeared in enhance the induction of suppressor cells in these cultures. Maximum enhancement of suppressor cell induction occurred at an MP concentration of approximately 1 μg/ml. Moreover, the presence of low concentrations of methylprednisolone, not sufficient to inhibit proliferation in MLC significantly potentiated the inhibiting effect of suppressor cells on cellular proliferation. The inhibition observed by the combined effect of MP and suppressor cells was equivalent to that seen using five times as many suppressor cells alone.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Human suppressor cells generated in mixed lymphocyte cultures (MLC) appear to inhibit both cellular proliferation and the mitogenic effects of blastogenic factor (BF). The results presented here indicate that the inhibition of BF by alloantigen-activated lymphocytes is not due to decreased lymphocyte proliferation as such, since BF normally produced by non-proliferating cultures was also suppressed. Moreover, the inhibition was not caused by direct suppression of the BF-producing lymphocytes, since incubation of BF with alloantigen-activated lymphocytes neutralized the mitogenic effects of BF. We therefore conclude that activated lymphocytes generated in human MLC directly inhibit or utilize BF. Our experiments also indicate that the activated lymphocytes do not have to proliferate to inhibit BF activity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 6 (1977), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Lymphocytes transferred from 6-day-old human mixed lymphocyte cultures (MLC) inhibited the response to allogeneic cells of freshly taken lymphocytes autologous to the transferred MLC-responding cells. No specificity for this cell-dependent suppression could be determined. The inhibitory effects of the suppressing cells could be abrogated by moderate X-ray irradiation and significantly reduced by pretreating them with an anti-Ia-like antiserum and complement, Tin-human suppressor cell responsible for the observed effects therefore appears to carry determinants equivalent to the murine Ia alloantigens.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 9 (1979), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Incuhation of human monocylcs, derived from peripheral blood, with cell-free supernalants from mixed lymphocyle cultures resulted in mcirpholngical and funelional changes in the mature macropliages. Activation of monocyle-derived macrophages by these faciors resulted in a significant increase in their capacity to lyse anti-D-trealed human erythrticytcs. The tytic activity of both normal and activated macrophages appeared to be independent of eryihrophagocytosis. T lymphocytes activated by either allogeneic cells or ihe mitogen phytohaemagglutinin were not cytolytic lo treated eryihrocytes even at high effector to target cell ratios.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    The @journal of African history 4 (1963), S. 313-339 
    ISSN: 0021-8537
    Quelle: Cambridge Journals Digital Archives
    Thema: Geschichte
    Notizen: Students of the history of North Africa in general, and of the history of the Jews there in particular, commonly think that a considerable proportion—one half or more—of the Jews who live, or until recently lived, in North Africa are descended from the Berbers, who prior to the Arab conquest formed the overwhelming majority of the population. In their opinion, these Jews were the offspring of tribes among which Jewish beliefs spread in the pre-Arab era and part of which actually embraced Judaism. This assumption, which seemingly answers the question as to the origin of the Jews who inhabited the North African hinterland, and especially the districts bordering on the Sahara, has gained such wide currency that the term ‘Berber Jew’ has been coined, i.e. Jew descended from Judaized Berbers. The proponents of this assumption apparently suppose that the stories of Jews, or Judaized people, living among Berber tribes, though describing events of the late Middle Ages or of modern times, reflect conditions precedent to the Muslim conquest of North Africa. In other words, the supporters of the theory of the Judaized Berbers think that this phenomenon cannot have originated in Muslim times since the new religion precluded every chance of Jewish proselytizing. If, therefore, Judaized people are found in Africa, even in recent times, they must be remnants of a religious movement going back to the period before the Arab conquest. In the view of the adherents of this theory, Judaism spread among the Berbers during the first centuries of the Christian era.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 21 (1985), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: T cells primed to Chlamydia trachomatis serolypes A, F. and K were cloned by limiting dilution. All T-lymphocyte clones obtained reacted only with C. trachomatis antigens. The proliferate capacity of 89 clones was studied with autologous non-T cells as antigenpresenting cells and the chlamydia serotypes A, B, D, F, K, and LGV-2 as antigens. Most of the clones reacted to several of the chlamydia strains, indicating common antigenic determinants. Other T-cell clones reacted with only a few serotypes. On the basis of the proliferation of the T-cell clones to the chlamydia strains and to interleukin-2, different reactivity patterns were obtained, which possibly can be used to differentiate among the chlamydia strains.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effects of short-term incubation with hydrocortisone and methylprednisolone on the alloactivating capacity and the ability of human epidermal Langerhans cells and peripheral blood monocytes to induce antigen (PPD)-specific T-lymphocyte responses were investigated. The Langerhans cells and the monocytes were treated with different concentrations of the steroids before being added to allogeneic T lymphocytes, and before, after or simultaneously with, pulsing with PPD. Neither steroid inhibited the alloactivating capacity of the Langerhans cells, but a dose-dependent reduction of the stimulatory capacity of antigen-pulsed Langerhans cells and monocytes was obtained with methylprednisolone. Hydrocortisone had inhibitory effects only at high concentration. The inhibition appeared to be due to suppression of the presentation of PPD in immunogeneic form to sensitized T cells.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 62-64 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Antibody-induced cell-mediated cytotoxicity (AICC) has been reported previously, using a variety of allo- or xenogeneic target cells7"*9 and could be an important in vivo mechanism in the rejection of allografts. Here we describe damage to 51Cr-labelled dissociated human endothelial cells in ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 263 (1976), S. 63-64 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Leukocytes were separated from human peripheral blood by Ficoll-Isopaque flotation. Relatively pure macrophage populations were obtained by incubating the isolated leukocytes in plastic flasks for 8 h. The non-adherent cells, mainly lymphocytes, were decanted by repeated washing and the adherent ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 18 (1983), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Coeliac disease (CD) is strongly associated with the human class-II HLA determinants HLA-DR3 and -DR7. We investigated the relative frequency of gluten-reactive T cells from DR3- or DR7-positive CD patients and healthy controls who were heterozygous at the DR locus. We found a consistently and significantly lower frequency of gluten-reactive T cells when the antigen was presented by monocytes in conjunction with DR3 or DR7 than in conjunction with the other DR determinant of the T-cell donor. In contrast, the frequency of reactive T cells in these donors to other antigens was not reduced in conjunction with DR3 or DR7. These results indicate a specific immunoregulatory function associated with class-II HLA molecules. The reduced frequency of gluten-reactive T cells in association with HLA-DR3 or -DR7 may be directly involved in the development of CD.
    Materialart: Digitale Medien
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