ISSN:
1435-5922
Keywords:
Key words: chromosome 17
;
fluorescence in-situ hybridization (FISH)
;
gastric cancer
;
lymph node metastasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract: We investigated the correlation between the frequency of numerical aberrations of chromosome 17 and clinicopathological features of gastric cancer. The copy number of chromosome 17 was examined with fluorescence in-situ hybridization (FISH) in frozen specimens from 100 primary gastric cancers. Chromosomal numerical aberrations were diagnosed as chromosomal loss (single signal) or gain (triple or more signals), in each cell. The frequency of numerical aberrations of chromosome 17 correlated significantly with the depth of invasion (P 〈 0.01), lymph node metastasis (P 〈 0.0001), lymphatic invasion (P 〈 0.001), and venous invasion (P 〈 0.01). Numerical aberrations of chromosome 17 were associated with lymph node metastasis in 32 early gastric cancers. Multiple regression analysis identified the depth of invasion and numerical aberrations of chromosome 17 as independent significant determinants of lymph node metastasis. Our findings suggest that alterations in chromosome 17 may be linked with tumor progression in primary gastric cancer. Our results also indicate that numerical aberrations of chromosome 17 detected by FISH provide important information about the malignant potential (in particular, lymph node metastasis) of primary gastric cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s005350050210
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