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  • 1
    Electronic Resource
    Electronic Resource
    Choroid plexus tumors in childhood (1991)
    Springer
    Child's nervous system 7 (1991), S. 437-441 
    Details
    ISSN: 1433-0350
    Keywords: Choroid plexus tumor ; Immunohistochemistry ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263185
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Familial neurofibromatosis 1 with germinoma involving the basal ganglion and thalamus (1995)
    Springer
    Child's nervous system 11 (1995), S. 456-458 
    Details
    ISSN: 1433-0350
    Keywords: Neurofibromatosis 1 ; Intracranial ; Germinoma ; Autosomal disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracranial germinoma associated with neurofibromatosis 1 (NF-1) has never been documented previously. We report a case of familial NF-1 with a germinoma involving the right basal ganglion and thalamus. A 12-year-old boy presented with multiple café-au-lait spots and a family history of neurofibromatosis in his mother, one of two siblings, and his maternal grandfather. His intracranial lesion was subtotally resected. Histologically, it was a pure germinoma. Serum α-feto protein and β-human chorionic gonadotropin levels were within the normal range. Postoperative myelographic examination and cerebrospinal fluid cytology study showed no evidence of subarachnoid seeding. The patient received postoperative combination chemotherapy resulting in complete response and clearance of the residual tumor. Although this finding of an intracranial germinoma in a patient with familial NF-1 may be coincident, it is suggestive of a potential genetic predisposition. Longitudinal evaluation for the possibility of neoplasm, especially germ cell tumor, in basal ganglion lesions in NF-1 patients is necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334965
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Congenital cerebral primitive neuroectodermal tumor with astrocytic differentiation and extracranial metastases (1990)
    Springer
    Child's nervous system 6 (1990), S. 179-182 
    Details
    ISSN: 1433-0350
    Keywords: Primitive neuroectodermal tumor ; Extracranial metastases ; Astròcytic differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cerebral primitive neuroectodermal tumor with astrocytic differentiation and extracranial metastases in a 28-day-old infant is reported. The infant presented with a progressively enlarged head, cutaneous lesions in the neck, and enlarged cervical lymph nodes. A computed tomography brain scan demonstrated a giant thalamic tumor with subarachnoid dissemination and hydrocephalus. Biopsy material from the cervical lesions showed a picture of glioma with anaplastic astrocytes. The patient received a ventriculoperitoneal shunt operation and palliative chemotherapy, but died at 3 months of age. Autopsy was performed. Histological studies, which included immunohistochemical stains of the thalamic tumor, showed small, round, primitive, neoplastic cells with focal astrocytic differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308497
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    Paper (German National Licenses)
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