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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Selenium on 1,2-dimethylhydrazine-induced intestinal cancer in rats (1996)
    Springer
    Diseases of the colon & rectum 39 (1996), S. 628-631 
    Details
    ISSN: 1530-0358
    Keywords: Selenium ; Intestinal cancer ; 1,2-dimethylhydrazine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to determine the cancer prevention and therapeutic effects of selenium on rats treated with 1,2-dimethylhydrazine (DMH). METHODS: One hundred sixty Spraque-Dawley male rats were divided into seven groups and received 20 mg/kg/week DMH, subcutaneously for 20 weeks. Two different dosages of selenium (8 and 4 ppm) were administered to the rats through drinking water during DMH treatment (B and C groups) or one month before and during DMH treatment (D and E groups). The rats of Groups A (control group), B, C, D, and E were killed immediately after the last DMH injection. The incidence of intestinal cancer in each group was compared. Eight ppm selenium was also administered to rats after DMH treatment (Group F), and survival times were observed and compared with Group G (treated with DMH only). RESULTS: Rats of Groups B and D received 8 ppm selenium and had a significantly decreased incidence of intestinal cancer (from 65.8 percent (Group A) to 33.3 percent (Group B) and 27.8 percent (Group D);P=0.0225 and 0.0038). Rats receiving 4 ppm selenium had a relatively decreased incidence of intestinal cancer (from 65.8 percent (Group A) to 44.4 percent (Group C) and 47.1 percent (Group E) but P〉 0.05). Survival time of Groups F and G showed no difference. CONCLUSIONS: Eight ppm selenium provided via drinking water has a significant intestinal cancer prevention effect in the presence of a high dose of DMH (20 mg/kg×20 weeks), and the cancer therapeutic effect of selenium is doubtful in this animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02056940
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of germanium on 1, 2-dimethylhydrazine-induced intestinal cancer in rats (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 99-104 
    Details
    ISSN: 1530-0358
    Keywords: Germanium ; Colon cancer ; 1, 2-Dimethylhydrazine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Through recent research, the trace element, germanium, was found to have an anticancer effect. The purpose of this research was to determine the effect of germanium on 1, 2-dimethylhydrazine-induced intestinal cancer in rats. Ninety-six 8-week-old Sprague-Dawley male rats were divided into 4 groups, with 24 rats in each group. All received dimethylhydrazine, 20 mg/kg body weight, subcutaneously, once a week for 20 weeks. Except for one control group, the other three groups were subdivided into six groups and administered three different kinds of germanium (inorganic germanium, organic germanium, and natural organic germanium) one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment, respectively. Twenty-four weeks after carcinogen exposure, all surviving animals were sacrificed and examined for intestinal tumors. The number and location of the tumors were recorded and the pathology examined. The incidence of intestinal cancer in the control group (dimethylhydrazine only) was 91 percent; in groups provided with inorganic germanium one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment only, it was 91 and 78 percent; in groups provided with organic germanium one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment only, it was 64 and 64 percent; in groups provided with natural organic germanium one month before and during dimethylhydrazine treatment and during dimethylhydrazine treatment only, it was 50 and 45 percent. From these results, the authors conclude that natural organic germanium has the best prevention effect for intestinal cancer in this animal model (P〈0.01), followed by organic germanium (P 〈0.05). Inorganic germanium has no effect. However, there is no difference in the cancer prevention effect of germanium provided one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02055535
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  • 3
    Electronic Resource
    Electronic Resource
    Pathogenetic implications of DNA nondiploidy in colorectal cancers (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 1244-1247 
    Details
    ISSN: 1530-0358
    Keywords: Colorectal cancer ; DNA ploidy ; Pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Several studies propose that proximal and distal colorectal cancers have a different pathogenesis. We tested the hypothesis using flow cytometric DNA analysis. METHODS: DNA analysis was performed in 719 patients with colorectal cancer. In addition, histopathologic data were re-evaluated in a blinded fashion by a single pathologist. RESULTS: Distal tumors were more often nondiploid than were proximal tumors (61 vs.49 percent;P =0.015). Compared with the proximal tumor, distal tumors were smaller ( P =0.0001) and had less desmoplastic reaction (39 vs.53 percent;P =0.0001). Tumor location had no significant associations with the remaining parameters, including mucin production, perineural invasion, blood/lymphatic vessel invasion, lymphocytic infiltration, histologic grade, tumor stage, gross appearance, age, and gender. CONCLUSIONS: The unequal distribution of ploidy suggests distinct pathogenetic mechanisms at proximal and distal sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02055172
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  • 4
    Electronic Resource
    Electronic Resource
    Neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical surgery in early-stage bulky cervical carcinoma (1992)
    Springer
    Cancer chemotherapy and pharmacology 30 (1992), S. 281-285 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neoadjuvant chemotherapy consisting of 2–3 courses of cisplatin, vincristine, and bleomycin was used in the primary treatment of 36 consecutive patients with locally advanced early-stage cervical carcinoma [International Federation of Gynecology and Obstetrics (GIGO) stages I b or IIa; tumor size, ≥4 cm]. The effectiveness of the preoperative chemotherapy was evaluated in the surgical specimens. Among the 33 evaluable patients, the overall clinical response rate was 84.8%, which included a complete response in 8 patients (24.2%) and a partial response in 20 subjects (60.6%). No residual tumor was found in the surgical speciments obtained from 2 complete responders. This therapy induced varying degrees of tumor shrinkage and rendered radical surgery feasible in all evaluable cases despite the initial bulky size of the lesions. No significant difference was observed in the response rate according to age and disease stage. Lymph-node metastases were found after chemotherapy in 18.2% (6/33) of the patients. Grade II and III hematological toxicities occurred in 23.3% of the 90 chemotherapy cycles completed. Nausea and vomiting occurred to a mild to moderate degree in 75 (83.3%) cycles. These preliminary results suggest that the administration of induction chemotherapy involving two to three courses of cisplatin, vincristine, and bleomycin prior to surgery is effective in reducing the tumor volume and in providing better circumstances for surgical removal of the early yet bulky cervical tumors and results in tolerable toxicity. This protocol is now undergoing prospective randomized trials to test its impact on long-term survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686296
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  • 5
    Electronic Resource
    Electronic Resource
    Intraventricular neurocytoma: four cases report (1992)
    Springer
    Journal of neuro-oncology 13 (1992), S. 239-246 
    Details
    ISSN: 1573-7373
    Keywords: intraventricular neurocytoma ; clinicopathological features ; immunochemical stain ; ultrastructure ; oligodendroglioma ; neuroblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intraventricular neurocytoma, a newly identified disease entity with probably not so rare incidence, has several distinctive clinico-pathological characteristics. Four cases are presented. As in the other cases reported in the literature [1–7], the characteristic features are young age, location close to the junction of the septum pellucidum and foramen of Monro, and well-differentiated neuronal origin pathologically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172476
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  • 6
    Electronic Resource
    Electronic Resource
    Clinicopathological evaluation of 78 astrocytomas in Taiwan with emphasis on a simple grading system (1992)
    Springer
    Journal of neuro-oncology 13 (1992), S. 265-276 
    Details
    ISSN: 1573-7373
    Keywords: astrocytoma ; brain tumor ; grading method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The grading systems of astrocytic tumors have long been the subject of controversy. A simple, objective and effective grading method is urgently needed for the evaluation of prognosis and the planning of treatment. This study investigated the relationship of clinical prognostic factors to the grading method of Daumas-Duport. This method determines the grade of tumor based on the presence or absence of four morphological criteria: nuclear atypia, mitosis, endothelial proliferation, and necrosis. A total of 143 astrocytic tumors were reviewed and screened, of which 65 ordinary and 13 pilocytic astrocytomas were selected for grading and comparison. Among ordinary astrocytomas, the grading method distinguished 9.2% grade 1, 26.2% grade 2, 36.9% grade 3, and 27.6% grade 4. At least 2-year follow-up was available on all surviving patients. Median survival was 57, 32, 12.5, and 8 months in grades 1, 2, 3, and 4 tumors, respectively. By a multiple regression model and analysis of variance, grade is significantly associated with survival (total regression coefficient r = 0.711). Age lost its significance on survival after multiple regression analysis. Sex, location, and surgical procedure were all unrelated to survival after regression. The age distribution and survival of patients with pilocytic astrocytomas revealed that this is a distinct disease entity and should not be admixed with ordinary astrocytomas in a grading scheme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172480
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  • 7
    Electronic Resource
    Electronic Resource
    Nasopharyngeal carcinoma with brain metastasis: A case report (1994)
    Springer
    Journal of neuro-oncology 22 (1994), S. 227-230 
    Details
    ISSN: 1573-7373
    Keywords: nasopharyngeal carcinoma ; brain metastasis ; blindness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of nasopharyngeal carcinoma with brain metastasis of a 69-year-old man. The patient presented with blindness and a huge mass over right upper neck. The magnetic resonance imaging (MRI) showed right nasopharyngeal tumor and metastatic lesion in bilateral occiptal regions. The bony x-ray showed diffuse osteoblastic metastases. The brain lesion was pathology-proven through the computed-tomographic guidance sterotatic biopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052923
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  • 8
    Electronic Resource
    Electronic Resource
    Overexpression of cellular activity and protein level of protein kinase FA/GSK-3α correlates with human thyroid tumor cell dedifferentiation (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 58 (1995), S. 474-480 
    Details
    ISSN: 0730-2312
    Keywords: kinase FA/GSK-3α ; overexpression ; thyroid ; tumor cell dedifferentiation ; carcinogenesis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Computer analysis of protein phosphorylation sites sequence revealed that transcriptional factors and viral oncoproteins are prime targets for regulation of proline-directed protein phosphorylation, suggesting an association of the proline-directed protein kinase (PDPK) family with neoplastic transformation and tumorigenesis. In this report, an immunoprecipitate activity assay of protein kinase FA/glycogen synthase kinase-3α (kinase FA/GSK-3α) (a member of the PDPK family) has been optimized for human thyroid tissue and used to demonstrate for the first time significantly increased (P 〈 0.001) activity in thyroid carcinoma (24.2 ± 2.8 units/mg of protein) (n = 7), thyroid adenoma (14.5 ± 2.2 units/mg of protein) (n = 6), and thyroid hyperplasia (8.0 ± 2.4 units/mg of protein) (n = 5) when compared to five normal controls (4.1 ± 1.8 units/mg of protein). Immunoblotting analysis further revealed that increased activity of kinase FA/GSK-3α in thyroid tumor cells is due to overexpression of protein level and cellular activity of kinase FA/GSK-3α is involved in human thyroid tumor cell dedifferentiation, supporting an association of PDPK with neoplastic transformation and tumorigenesis. Since kinase FA/GSK-3α may function as a possible regulator of transcription factors/protooncogenes, kinase FA/GSK-3α may therefore play an important role in thyroid cell carcinogenesis, especially in its differentiation.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240580410
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  • 9
    Electronic Resource
    Electronic Resource
    Association of protein kinase FA/GSK-3α (a proline-directed kinase and a regulator of protooncogenes) with human cervical carcinoma dedifferentiation/progression (1995)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 59 (1995), S. 143-150 
    Details
    ISSN: 0730-2312
    Keywords: cervical carcinoma progression ; kinase FA/GSK-3α ; overexpression ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Computer analysis of protein phosphorylation-sites sequence revealed that most transcriptional factors and viral oncoproteins are prime targets for regulation of proline-directed protein phosphorylation, suggesting an association of proline-directed protein kinase (PDPK) family with neoplastic transformation and tumorigenesis. In this report, an immunoprecipitate activity assay of protein kinase FA/glycogen synthase kinase-3α (kinase FA/GSK-3α) (a particular member of PDPK family) has been optimized for human cervical tissue and used to demonstrate for the first time significantly increased (P 〈 0.001) activity in poorly differentiated cervical carcinoma (82.8 ± 6.6 U/mg of protein), moderately differentiated carcinoma (36.2 ± 3.4 U/mg of protein), and well-differentiated carcinoma (18.3 ± 2.4 U/mg of protein) from 36 human cervical carcinoma samples when compared to 12 normal controls (4.9 ± 0.6 U/mg of protein). Immunoblotting analysis further revealed that increased activity of kinase FA/GSK-3α in cervical carcinoma is due to overexpression of protein synthesis of the kinase. Taken together, the results provide initial evidence that overexpression of protein synthesis of the kinase. Taken together, the results provide initial evidence that overexpression of protein synthesis and cellular activity of kinase FA/GSK-3α may be involved in human cervical carcinoma dedifferentiation/progression, supporting an association of proline-directed protein kinase with neoplastic transformation and tumorigenesis. Since protein kinase FA/GSK-3α may function as a possible regulator of transcription factors/proto-oncogenes, the results further suggest that kinase FA/GSK-3α may play a potential role in human cervical carcinogenesis, especially in its dedifferentiation and progression. © 1995 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240590203
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