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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 29 (1990), S. 10883-10888 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 478 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. When mutations of the RET proto-oncogene were found in 1993 to account for hereditary medullary thyroid carcinoma (MTC), surgeons obtained the opportunity to operate on patients prophylactically (i.e., at a clinically asymptomatic stage). Whether this approach is justified, and, if so, when and to which extent surgery should be performed remained to be clarified. A questionnaire was sent to all surgical departments in Germany and Austria. All of the patients who fulfilled the following criteria were enrolled: (1) preoperatively proved RET mutation; (2) age ≤ 20 years, (3) clinically asymptomatic thyroid C cell disease; and (4) TNM classification pT0–1/pNX/pN0–1/M0. Seventy-five patients were identified, and fifteen mutations were detected in six codons. Two adolescents had unilateral pheochromocytomas as part of the multiple endocrine neoplasia II (MEN-II) syndrome. No hyperparathyroidism was noted. All patients underwent total thyroidectomy, and 57 patients went on to have lymph node dissection. Parathyroid glands were removed in 34 patients and autografted in 11. Histopathology revealed MTC in 46 patients (61%, youngest 4 years); C cell hyperplasia (CCH) only was detected in the other 29 patients. Three patients had lymph node metastases (LNMs) the youngest being age 14 years. Calcitonin levels were not useful for differentiating between CCH and MTC, but in all patients with LNMs at least the stimulated calcitonin levels were assayed. After surgery, five patients (6.7%) sustained permanent hypoparathyroidism, and one patient (1.3%) had a permanent unilateral recurrent nerve palsy. All but three patients (96%) were biochemically cured. In conclusion, prophylactic total thyroidectomy can be performed safely in experienced centers. We recommend prophylactic total thyroidectomy at age 6. Cervicocentral lymph node dissection should be included when calcitonin levels are elevated or if patients are older than 10 years. Bilateral lymph node dissection should be performed if LNMs are suspected or when patients with elevated calcitonin are older than 15 years.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1616-7228
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Description / Table of Contents: Summary Marine optical measurements taken from the research platform “Nordsee” have shown that, during severe storms, the turbidity in the water increases there to a multiple, principally owing to the influence of the state of the sea. The maximum concentration of suspended particle content during the period under observation (14. 11. to 8. 12. 1980) was estimated to be 300 mg/l according to measured turbidity and laboratory experiments. The light scattering and light transmission properties of the water differ each according to the particular sediment texture of the sea bottom over which the water flows.
    Abstract: Résumé Les mesures optiques dans l'eau de mer faites à partir de la plateforme de recherche «Nordsee» ont montré que, pendant les fortes tempêtes, la turbidité de l'eau augmentait pour atteindre des valeurs multiples de la valeur normale, principalement sous l'influence de l'état de la mer. Pendant la période d'observation (14 novembre au 8 décembre 1980) la teneur maximale en particules en suspension a été estimée à 300 mg/l d'après les mesures de turbidité et des expériences en laboratoire. Les propriétés de diffusion et de propagation lumineuse de l'eau de mer diffèrent toutes les deux selon la nature sédimentaire du fond au-dessus duquel l'eau s'écoule.
    Notes: Zusammenfassung Meeresoptische Messungen auf der Forschungsplattform “Nordsee” haben gezeigt, daß dort während schwerer Stürme, hauptsächlich durch den Einfluß des Seegangs, die Trübung im Wasser auf ein Mehrfaches ansteigt. Als maximale Schwebstoffkonzentration während der Beobachtungszeit (14. 11. bis 8. 12. 1980) wurden 300 mg/l nach gemessener Trübung und Laborexperimenten abgeschätzt. Die Lichtstreu- und-transmissionseigenschaft des Wassers unterscheiden sich je nach der Sedimentbeschaffenheit des überströmten Meeresbodens.
    Type of Medium: Electronic Resource
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