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An analysis of concordance among hospital databases and physician records (1998)

Holt, Ginger ; Feurer, Irene D. ; Schwartz, Herbert S.

Springer

Annals of surgical oncology 5 (1998), S. 553-556

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ISSN: 1534-4681

Keywords: Database ; Oncology ; Concordance ; κ statistic ; Orthopaedics

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Background: Hospital databases contain vital demographic patient information, which is increasingly being used as a basis to dictate care. It is hypothesized that the validity of data administratively generated from such sources is suboptimal, especially for rare subspecialties. The authors examined three databases to determine their concordance in an academic orthopaedic oncology subspecialty practice. Methods: A 2-year retrospective review was performed on three databases searching for seven fundamental variables: additions/deletions; identification number; birthdate; procedure date; admit/discharge date; procedure code; and diagnostic code. Two university-maintained hospital databases (medical records and physician billing) were compared to the surgeon's personal handwritten daily log, which served as the “gold standard.” Results: All seven variables were in agreement with the physician's log in only 60% of the medical records and 61% of the physician billing patient entries (n=564). On more detailed statistical analysis using x2, cross tabulations, and the κ statistic for interobserver agreement, it was determined that poor concordance exists among the databases. Conclusion: Surgeons delivering quartenary care should maintain his or her own database because the hospital's information often differs on one or more important variables. Further investigation into the accuracy of hospital databases regarding commonly practiced medical disciplines appears warranted.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02303650

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Acrosome reaction induced by immunoaggregation of a proteinase inhibitor bound to the murine sperm head (1991)

Aarons, David ; Boettger-Tong, Holly ; Holt, Ginger ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 30 (1991), S. 258-264

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ISSN: 1040-452X

Keywords: Zona binding ; Fab fragments ; Seminal vesicles ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: ZP3, a glycoprotein of the murine zona pellucida, functions both to bind acrosome intact sperm and to induce the acrosome reaction. Solubilized whole zonae as well as purified ZP3 are able to induce acrosome reactions in capacitated sperm. Pronase digests of whole zonae yield glycopeptides that bind to sperm but are unable to induce acrosome reactions. However, immunoaggregation of these glycopeptides results in the exocytosis of the acrosome in the majority of treated sperm. The data suggest that ZP3 triggers the acrosome reaction by the aggregation of ZP3 binding sites on the sperm head. If aggregation of ZP3 binding sites is important in the induction of the acrosome reaction, then it may be possible to induce the acrosome reaction in the absence of zona by immunoaggregation of the sites. This presentation deals with the immunoaggregation of a proteinase inhibitor of seminal vesicle origin (SVI) that binds to a site on the sperm head known to participate in zona binding. We show that capacitated murine sperm, pretreated with the SVI, will acrosome react, as determined by Coomassie brilliant blue staining, when incubated with rabbit antiinhibitor antiserum (anti-SVI). The percentage of SVI-treated sperm displaying an acrosome reaction is dependent on the concentration of the immune serum. Sperm stain positive for intact acrosomes when anti-SVI Fab fragments or normal rabbit serum is substituted for the immune serum. However, when capacitated sperm, treated with both SVI and anti-SVI Fab fragments, are incubated with goat antirabbit IgG, the majority of sperm acrosome react. The data suggest that the aggregation of SVI bound to the sperm surface, in the absence of zona glycoproteins, is sufficient to induce the acrosome reaction.

Additional Material: 8 Ill.