ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The didehydrocorrinoid derivative of vitamin B12, ‘pyrocobester’ 1 (hexamethyl Coα, Cob̃-dicyano-7-de (carboxymethyl)-7,8-didehydrocobyrinate), is oxygenated in the presence of visible light and molecular oxygen to give the previously unknown ‘5,6-dioxosecopyrocobester’ 3 (hexamethyl Coα, Cob̃-dicyano-5,6-dioxo-7-de(carboxymethyl)-7,8-didehydro-5,6-secocobyrinate) under regioselective cleavage of the macrocycle at the 5,6-position. Efficiency and yield of this reaction involving ‘singlet oxygen’ depend on the solvent used: with CCl4 a 96% yield of 3 is obtained.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660105
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