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  • 1
    Electronic Resource
    Electronic Resource
    The 43 kDa papain inhibitor in normal and diseased skin (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 15 (1988), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The presence of 43 kDa papain inhibitor in 43 different skin diseases was immunohistochemically studied by using both poly-and monoclonal antibodies. Psoriasis and various eczematoid reactions as well as viral infections showed the most pronounced staining in the squamous cells of the epidermis. The antigen was also present in benign tumours or precancerous lesions which showed keratinization. Cells of poorly differentiated squamous cell carcinomas, basal cell carcinomas and melanocytic tumours were negative. The antigen seems to be related to disturbed keratinization and benign proliferation in non-neoplastic derma-toses and it is also present in differentiating squamous neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1988.tb00567.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergy to various components of topical preparations in stasis dermatitis and leg ulcer (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients suffering from stasis dermatitis and leg ulcers (192) were found to give an allergic reaction in epicutaneous texts to one or more components of topical preparations in 69.2% of cases. The most common reactions were obtained with neomycin 34.0% and its component framycetin 31.2%, wool alcohols 22.9% balsam of Peru 21.4%, chlorquinaldon 16.7% bacitracin 13.1% chinoform 10.9% dequalin 9.9% formaldehyde 4.2% and parabens 3.6% The incidence of allergic reactions reflects local use of preparations containing various allergens as well sis their capacity to produce allergy. Allergy may in some CLISO interfere with effective topical therapy. Debrisan® dextran polymer heads were found to the suitable for treatment of ulcers of multiallergic patients without risk of contact allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb04806.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of five anti-inflammatory steroids on collagen and glycoaminoglycan synthessis in vitro (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of five anti-inflammatory corticosteroids, i. e. hydrocortisone, hydrocortisone 17-butyrate, betamethasone 17-valerate, nicocortonide acetate and nicocortonide, on the synthesis of hyaluronic acid, sulphated glycosaminoglycans and collagen by cultured skin fibroblasts was studied. As inhibitors of all these parameters the steroids could be arranged in order hydrocortisone 〈 hydrocortisone 17-butyrate 〈 betamethasone 17-valerate, nicocortonide acetate and nicocortonide. The corticosteroid concentrations required for inhibition of hyaluronic acid were very low as compared to those required for inhibition of sulphated glycosaminoglycan and collagen synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb06586.x
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  • 4
    Electronic Resource
    Electronic Resource
    Formation of Bradykinin from Kallidin-10 by Aminopeptidase B (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 1271-1272 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The preparation of aminopeptidase B used is described in ref. 2. Kallidin-10 and bradykinin were each incubated separately for 2-24 h with the enzyme preparation in a mixture containing 0-5 ml. 0-2 molar tris-hydrochloric acid buffer, pH 7-0, and 1 mg of the polypeptide and 0*25 ml. of enzyme ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2121271a0
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  • 5
    Electronic Resource
    Electronic Resource
    Dendritic reticulum cells in AIDS-related lymphadenopathy (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1173-1175 
    Details
    ISSN: 1420-9071
    Keywords: Immunohistochemistry ; immunologic deficiency syndromes ; lymph nodes ; protease inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary One of two cases of acquired immune deficiency syndrome-related persistent generalized lymphadenopathy revealed a profoundly altered pattern of dendritic reticulum cells as demonstrated by immunoreactive acid cysteine proteinase inhibitor. The alterations could be related to totally or partially destructed lymphoid secondary follicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951713
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  • 6
    Electronic Resource
    Electronic Resource
    A 43-kDa papain inhibitor produced by a cultured human epidermal cell line (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 372-376 
    Details
    ISSN: 1432-069X
    Keywords: Cysteine proteinase ; Proteinase inhibitor ; Epithelium cell culture ; Chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epidermis-derived cells (NCTC 2544) were cultured and the proteins of the culture medium, as well as of the cells, were fractionated by gel-chromatography. The fractions were analyzed for their papain-inhibitory capacity and for the presence of socalled 43-kDa papain inhibitor. A papain inhibitor was identified with molecular weight and immunological characteristics similar to the original 43-kDa inhibitor that was isolated from psoriatic scales. The result proves that NCTC-2544 cells can produce the so-called psoriasis inhibitor under culture conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418165
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  • 7
    Electronic Resource
    Electronic Resource
    Candida sonckii sp. nov. (1978)
    Springer
    Antonie van Leeuwenhoek 44 (1978), S. 435-438 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A new yeast species with basidiomycetous affinities is described as Candida sonckii Hopsu-Havu et al. It differs from C. fujisanensis and C. maris by growing with KNO3 as nitrogen source, from C. vanderwaltii by its lower mol % G+C, lower maximum temperature for growth and failure to grow on D-arabinose and citrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394319
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  • 8
    Electronic Resource
    Electronic Resource
    Immunoglobulin E in the human atopic skin (1973)
    Springer
    Archives of dermatological research 246 (1973), S. 299-302 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Immunglobulin E-Gehalt atopischer sowie nichtatopischer Haut wurde nach Kochsalzextraktion von Hautbiopsien mit einer Radio-Immunmethodik gemessen. Im Vergleich zu normaler, nichtatopischer Haut zeigte die nicht erkrankte Haut von Patienten mit Neurodermitis eine mehr als zweifach erhöhte Konzentration von IgE. Die erkrankte Haut dagegen enthielt fast eine dreifach erhöhte Konzentration von IgE. Eine direkte Korrelation zwischen Serum und Haut-IgE-Spiegel konnte nicht beobachtet werden.
    Notes: Summary The immunoglobulin E content of non-atopic and atopic skin has been measured in saline extracts of skin biopsies, using the radio-immunosorbent method. Compared to normal non-atopic skin, the clinically uninvolved skin of patients suffering from atopic dermatitis contained a more than 2-fold concentration of IgE, while clinically affected skin contained an almost 3-fold concentration, on the average. No simple correlation between serum and skin IgE levels could be found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595211
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  • 9
    Electronic Resource
    Electronic Resource
    Cysteine proteinase inhibitors in psoriatic epidermis (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 305-309 
    Details
    ISSN: 1432-069X
    Keywords: Proteinase inhibitors ; Psoriasis ; Epidermis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human psoriatic epidermis and scales were demostrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7–5.0 (ACPI) and one neutral with an isoelectric point of 6.0–6.5 (NCPI), while normal epidermis contains only ACPI. The total papain (cysteine proteinase) inhibiting activity of the psoriatic epidermis as calculated per mg protein was higher than that in normal epidermis. Both ACPI and NCPI were localized immunocytochemically, mainly in the highest spinous cell layers with less activity in the parakeratotic cells and lower layers of spinous cells. Basal cells were essentially negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417202
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  • 10
    Electronic Resource
    Electronic Resource
    Localization of cathepsin H and its inhibitor in the skin and other stratified epithelia (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 190-194 
    Details
    ISSN: 1432-069X
    Keywords: Cathepsin H ; Skin ; Epidermis ; Cysteine proteinase ; Proteinase inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The rat-skin-derived cysteine proteinase, so-called BANA-hydrolase, which is capable of hydrolysing benzoylarginine naphthylamide and leucine naphthylamide was shown to be immunologically identical to cathepsin H purified from rat liver. The enzyme was immunocytochemically localized in the basal cell layer of rat epidermis. A natural inhibitor of cathepsin H with a molecular weight of about 13,000 was mainly localized in the keratinizing cell layers and showed only a weak reaction in the basal cells. Thus, cathepsin H appears to be a characteristic feature of the proliferating cell layer, whereas the cysteine-proteinase inhibitor is a characteristic feature of keratinizing cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404315
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