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  • 1
    Electronic Resource
    Electronic Resource
    THE N-ACETYL-β-d-HEXOSAMINIDASES OF CALF AND HUMAN BRAIN (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Multiple forms of calf brain N-acetyl-β-hexosaminidases (β-2-acetamido-2- deoxy-d-glucoside acetamidodeoxyglucohydrolase EC 3.2.1.30) were separated on starch gel electrophoresis at pH 5.8. The organ specific electrophoretic patterns did not depend on the cell fraction studied. Much of the activity is only separated with difficulty from particulate matter. Two major and one minor component were separated on DEAE-cellulose chromatography at pH 5.8. Each component had both N-acetyl-β-galactosaminidase and N-acetyl-β-glucosaminidase activity. The ratio of these two activities was unaffected by the presence of N-ethylmaleimide or dithiothreitol. The forms were also examined by isoelectric focusing when at least four components were recognized: isoelectric at 4.9, 6.0, 6.3 and 6.8. Interconversion of the 4.9 form to that isoelectric at pH 6.0 was noted during vacuum dialysis. Samples from normal human brain and from cases of Tay-Sachs disease were also examined and the results compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01487.x
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  • 2
    Electronic Resource
    Electronic Resource
    Glomerular perfusion in renal allograft biopsies (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 22 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the commonest causes of impaired renal transplant function there is reduced renal and glomerular perfusion. We investigated the possibility of identifying this phenomenon in renal transplant biopsies, by the crude but simple method of counting the mean numbers of glomerular capillary loops which contained erythrocytes. In cyclosporin toxicity, acute tubular necrosis and in acute cellular rejection there was a considerable reduction in the numbers of erythrocyte-containing glomerular capillaries. The separation of the acute tubular necrosis group from normal was almost complete. This feature is therefore not specific but appears to correlate well with states of impaired glomerular perfusion. We suggest that a simple assessment of glomerular erythrocyte ‘load’ forms a useful part of the histological examination of renal transplant biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00071.x
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  • 3
    Electronic Resource
    Electronic Resource
    A comparison of methods for determining genotypes at the tumour necrosis factor-α−308, interleukin (IL)-1β+3953, IL-6 −174 and IL-10 −1082/−819/−592 polymorphic loci (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of immunogenetics 32 (2005), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Induced heteroduplex genotyping (IHG) is one of many methods that can be used to determine single nucleotide polymorphisms (SNPs). It is relatively new in comparison to other polymerase chain reaction (PCR)-based techniques. The aim of this study was to compare the results of genotyping using IHG with the results of genotyping using either polymerase chain reaction–sequence-specific primers (PCR-SSP) or polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for SNPs in the tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10 genes. Ninety patients who consented to participate in the study had their genotypes determined by IHG and either PCR-SSP (TNF-α−308 and IL-10 −1082/−819/−592) or PCR-RFLP (IL-1β+3953 and IL-6 −174). Results for each locus were compared between techniques by calculating the Kappa statistic as a measure of agreement. The IHG and more traditional genotyping methods produced very similar results at all loci. The Kappa statistics for each locus were as follows: TNF-α−308, K = 0.727; IL-1β+3953, K = 0.886; IL-6 −174, K = 0.909; IL-10 −1082, K = 0.876; IL-10 −592, K = 0.920. IHG is a valid method for the determination of genotypes at the loci examined in this study and produces comparable results to those of more traditional methods of genotyping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.2005.00494.x
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  • 4
    Electronic Resource
    Electronic Resource
    A protein-binding assay for measurement of biotin in physiological fluids
    Amsterdam : Elsevier
    Clinica Chimica Acta 82 (1978), S. 215-223 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(78)90002-5
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  • 5
    Electronic Resource
    Electronic Resource
    Glutamine synthetase in kidneys of monkey and man
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 60 (1978), S. 501-503 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(78)90085-8
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  • 6
    Electronic Resource
    Electronic Resource
    Suppression of in vitro lymphocyte reactivity by cyclosporin A: existence of a population of drug-resistant cytotoxic lymphocytes (1980)
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 609-611 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Cyclosporin A (CS-A) was added at different times after initiation of MLR between CBA (H-2k) responder cells and irradiated BALB/c (H-2d) or DBA/2 (H-2d) splenic stimulator cells (Fig. 1). The presence of CS-A from the beginning of culture caused almost complete inhibition of 3H-thymidine (3H-Tdr) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/286609a0
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  • 7
    Electronic Resource
    Electronic Resource
    The relative influence of delayed graft function and acute rejection on renal transplant survival (1996)
    Springer
    Transplant international 9 (1996), S. 415-419 
    Details
    ISSN: 1432-2277
    Keywords: Delayed graft function, graft survival, kidney ; Graft survival, kidney, delayed graft function ; Kidney graft survival, delayed graft function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three hundred and eight cadaveric renal transplants were analysed to establish the effects of acute rejection in the first 90 days and delayed graft function (DGF) on graft outcome. There were 120 patients (39%) with no DGF and no rejection (group 1), 101 patients (33%) with rejection but no DGF (group 2), 41 patients (13%) with DGF but no rejection (group 3) and 46 patients (15%) with both rejection and DGF (group 4). The actuarial 4-year graft survival rates for groups 1,2,3 and 40.4%, respectively. The acute rejection rate was 101/221 (46%) in patients with initial graft function compared with 46/87 (53%) for those with DGF (χ2=1.02, P=0.31). Cox stepwise logistic regression analysis demonstrated that DGF was a more powerful predictive factor for poor graft survival (P=0.001) than acute rejection occurring in the first 90 days post-transplant (P=0.034). Further efforts at improving graft outcome should concentrate on reducing the incidence of DGF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335705
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