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  • 1
    Digitale Medien
    Digitale Medien
    A Comparison of Chemical and Photochemically Induced Reduction of Some 2(4),5-Dihydro-1,2,4-triazines and Aromatic 1,2,4-Triazines (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 685-689 
    Details
    ISSN: 1434-193X
    Schlagwort(e): Single-electron transfer ; Ring contractions ; 1,4-Dihydro-1,2,4-triazine ; Photochemical reduction ; Chemical reduction ; Chemistry ; General Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: -Chemical reduction (Zn/AcOH) of the arene 1 and of 2(4),5-dihydro-1,2,4-triazine 7 has been reinvestigated, resulting in the amendment of literature data concerning this reaction. Chemical, electrochemical, and photochemically induced reductions and ring contractions of 1,2,4-triazine derivatives have been compared. The first example of a triaryl-1,4-dihydrotriazine has been prepared. Some further evidence is presented that supports the proposed mechanism of the photochemically induced reduction and ring contraction of 1,2,4-triazines.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    New antitumor leads from a peptidomimetic library (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 325-333 
    Details
    ISSN: 1573-3904
    Schlagwort(e): antiproliferative effect ; apoptosis ; combinatorial library ; isosteric structures ; oxaniloyl hydrazides ; peptidomimetics ; substrate-binding site ; tyrosine kinase inhibition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A parallel combinatorial library of over 1600 compounds has been designed and synthesized for the development of new potential peptidomimetic protein tyrosine kinase (PTK) inhibitor leads. These peptidomimetic molecules are aimed at intervening with the substrate binding site of the pp60c-src enzyme. The new structures were based on known PTK inhibitors with at least two variously substituted aromatic moieties attached by spacer groups of different length and flexibility. Eleven bis-aryl-type inhibitory compounds were found in the range of 18–100 μM IC50 concentrations from combinations of 12 different substituents. Molecular modeling of the active compounds showed a characteristic distance of 12–14 Å between the farthest sp2 carbon atoms of the two aromatic rings. Conformational analysis of several peptide substrates recently found for pp60c-src PTK showed that the energy-minimized conformers had the same distance between the two aromatic moieties. Several compounds in the library not only showed remarkable PTK inhibitory activity but also a significant apoptosis-inducing effect on HT-29 human colon tumor cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008994116275
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  • 3
    Digitale Medien
    Digitale Medien
    New antitumor leads from a peptidomimetic library (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 325-333 
    Details
    ISSN: 1573-3904
    Schlagwort(e): antiproliferative effect ; apoptosis ; combinatorial library ; isosteric structures ; oxaniloyl hydrazides ; peptidomimetics ; substrate-binding site ; tyrosine kinase inhibition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A parallel combinatorial library of over 1600 compounds has been designed and synthesized for the development of new potential peptidomimetic protein tyrosine kinase (PTK) inhibitor leads. These peptidomimetic molecules are aimed at intervening with the substrate binding site of the pp60c−src enzyme. The new structures were based on kown PTK inhibtors with at least two variously substituted aromatic moieties attached by spacer groups of different length and flexibility. Eleven bis-aryl-type inhibitory compounds were found in the range of 18–100 μM IC50 concentrations from combinations of 12 different substituents. Molecular modeling of the active compounds showed a characteristic distance of 12–14 Å between the farthest sp2 carbon atoms of the two aromatic rings. Conformational analysis of several peptide substrates recently found for pp60c−src PTK showed that the energyminimized conformers had the same distance between the two aromatic moieties. Several compounds in the library not only showed remarkable PTK inhibitory activity but also a significant apoptosis-inducing effect on HT-29 human colon tumor cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02443428
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  • 4
    Digitale Medien
    Digitale Medien
    Analysis of macromolecular branched chain polypeptides by capillary electrophoresis and micellar electrokinetic chromatography (1996)
    Weinheim : Wiley-Blackwell
    Electrophoresis 17 (1996), S. 1357-1360 
    Details
    ISSN: 0173-0835
    Schlagwort(e): Capillary electrophoresis ; Micellar electrokinetic chromatography ; Macromolecular branched chain polypeptides ; Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Amphoteric poly(Lys-[Glu1.0-DL-Ala4.1]), (EAK) and anionic poly(Lys-Ac-Glu0.98-DL-Ala3.98]), (AcEAK) branched chain polypeptides were analyzed by capillary electrophoresis (CE) and micellar elektrokinetic chromatography (MEKC) in the following buffers. A1: 0.25 N triethyl ammonium phosphate (TEAP) buffer (pH 2.25); A2: 100 mM sodium dodecyl sulfate (SDS) in buffer A1; B1: Na-borate buffer (pH 7.7); B2: 100 mM SDS in buffer B1; C1: Na-borate buffer (pH 11.0); C2: 100 mM SDS in buffer C1. Both EAK and AcEAK could be separated by a CE mechanism at pH 2.25 and by an MEKC mechanism at pH 11.0. Optimum results were achieved with CE in buffer A1 and with MEKC in buffer C2.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/elps.1150170813
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  • 5
    Digitale Medien
    Digitale Medien
    Analysis of polyanionic macromolecular carrier poly-(N-vinylpyrrolidone-co-maleic acid) and its bioconjugates by capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 295-299 
    Details
    ISSN: 0173-0835
    Schlagwort(e): Capillary zone electrophoresis ; Micellar electrokinetic chromatography ; Polyanionic macromolecular carrier ; Conjugate ; Tyrosine kinase molecule ; Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Aninonic carrier poly(N-vinylpyrrolidone-co-maleic acid) and its conjugates, prepared with coupling of 2-cyano-3-hydroxy-5-amino-2-pentenoyc(4-trifluoromethyl anilide) or (6′,7′-dimethyl-1′-quinoxalinyl)-4-(2′ amino) acetanilide to the carrier, were analyzed by capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) in the following buffers: 0.25N triethylammonium phosphate (TEAP); sodium dodecyl sulfate (SDS; 25-150 mM) in TEAP (pH 2.25-6.30); 0.1 M Na-borate buffer (pH range 7-11) and SDS (25-150 mM) in Na-borate buffer (pH range 7-11). The presence of strong carboxyl groups (dissociated even at pH 2.25) on the polymer chain was proved by the CZE method. It was also proved by potentometric titration that carboxyls with a wide range of acidity were on the polymer chain. CZE was able to differentiate among the analytes possessing carboxyl groups of different acidic strengths at pH 2.25. These components were not distinguished by CZE at high pH va use (11.0). Interaction between the analyte and SDS affected the separation at this pH, and hence good resolution was obtained by MEKC. Informative separations were achieved both for the carrier and the conjugates in TEAP buffer at pH 2.25 by the CZE method. Optimal separation was achieved in borate buffer containign 75 mM SDS at pH 11.0 for the carrier and at pH 7.7 for the conjugates in MEKC.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/elps.1150190225
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  • 6
    Digitale Medien
    Digitale Medien
    Comparative analysis of somatostatin analog peptides by capillary electrophoresis and micellar elektrokinetic chromatography (1996)
    Weinheim : Wiley-Blackwell
    Electrophoresis 17 (1996), S. 758-761 
    Details
    ISSN: 0173-0835
    Schlagwort(e): Capillary electrophoresis ; Micellar electrokinetic chromatography ; Somatostatin analog peptides ; Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Capillary electrophoresis (CE) and micellar electrokinetic chromatography (MEKC) methods, utilizing uncoated silica capillary and triethyl ammonium phosphate or sodium borate buffers in the pH range of 2.25-11.0, containing sodium dodecyl sulfate (SDS) (0-100 mM) for analysis of somatostatin-analog peptides were developed. The method presented here was compared with the reversed-phase high performance liquid chromatographic (RP-HPLC) and CE methods developed for analysis of peptides. The peptides investigated in this work can be separated by CE on the basis of their electrophoretic mobility in aqueous buffer of low pH value (pH 2.25) or by MEKC on the basis of their hydrophobicity in SDS containing buffer of high pH value (pH 11.0). Optimal MEKC separation of the investigated peptides has been achieved at pH 11.0 in an Na-borate buffer containig 100 mM SDS. CE at pH 2.25 proved insensitive to the hydrophobicity of the peptides investigated. By contrast, results obtained with MEKC at pH 11.0 proved to be anologous to those obtained by RP-HPLC, with highly hydrophobic peptides - migrating slower than peptides without hydrophobic moieties.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/elps.1150170422
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