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  • 1
    Electronic Resource
    Electronic Resource
    THE COLLAGENOLYTIC ACTIVITY OF PANCREAS (1962)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 93 (1962), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1962.tb30522.x
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  • 2
    Electronic Resource
    Electronic Resource
    CHEMISTRY OF INFLAMMATION (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 105 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb42962.x
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  • 3
    Electronic Resource
    Electronic Resource
    Proposed Mode of Action of Corticosteroids on the Connective Tissue (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 158-160 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE the announcement by Hench et al.1 of the dramatic effects of adrenal corticosteroids on. patients with 'collagen diseases', considerable interest has been expressed in the effects of corticosteroids on the collagen composition of the connective tissue.. Chemical studies2 have shown that the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206158a0
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  • 4
    Electronic Resource
    Electronic Resource
    Skin reactive factor and lymph node permeability factor (1973)
    Springer
    Inflammation research 3 (1973), S. 278-283 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have compared the properties of lymph node extracts from rat tissue with the properties of the supernatant obtained from the lectin-transformed rabbit peritoneal exudate lymphocytes in culture. Both extracts possess large amounts of lysosomal hydrolases, including particularly a cathepsin D-like protease. Both extracts are capable of increasing cutaneous permeability in the rat and causing a significant amount of cellular infiltration into the site of injection in the skin of these animals. This permeability-increasing activity and the cellular infiltration response to injection of these materials is completely inhibited by pepstatin and not by a variety of other inhibitors. Both extracts' permeability-increasing activity has a molecular weight range between 50,000 and 100,000 daltons and an isoelectric point of approximately 4.2. The molecular weight, the isoelectric point, and the inhibition by pepstatin are characteristic of cathepsin D from liver or spleen or granulocytes. Like cathepsin D, the permeability factor from LNPF and SRF extracts will release acid kinins from substrates which have been shown by Greenbaum and Houck to exist in the ground substance of rat skin. Finally, the breakdown products of the hydrolytic action of cathepsin D-like enzymes found in both lymph node extracts and supernatant from transformed lymphocytes are chemotactic for white blood cells. Thus, the two properties of cathepsin D described above, namely (a) the release of acid kinins which are capable of increasing the permeability of the microcirculation, and (b) the generation of chemotactic breakdown products via proteolysis could explain the two primary biological effects of both lymph node permeability factor and skin reactive factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986481
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  • 5
    Electronic Resource
    Electronic Resource
    The biochemistry of lymphocyte-derived mediators of immunological inflammation (1978)
    Springer
    Inflammation research 8 (1978), S. 73-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Evidence is presented to indicate that there exists in lymphoid tissue, as a result of transforming lymphocytes, a new lymphokine which is chemotactically specific for lymphocytes, called ‘lymphotactin’. Lymphotactin has been purified to electrophoretic homogeneity; has a molecular weight of 10,500 D and an isoelectric point of 5.9. Its role in amplifying the immune defense system by recruitment of naive lymphocytes into propinquity with the challenging antigen is suggested. Purification of macrophage migration inhibitory factor from thymus extracts to electrophoretic homogeneity leads to a compound of molecular weight of 36,500 D and an IEP of 6.9. Chemically it contains sialic acid ando-methyl glucopyranoside as its only carbohydrates. Purified MIF activates the macrophage phagocytically. Skin reactive factor and lymph node permeability factor have been isolated and purified and are found to be inhibited by pepstatin and antihistamine and to have an isoelectric point of pH 4.2 and a molecular weight of 50,000–100,000 D. It is believed that this anionic permeability increasing agent actually arises from the lysosomes of macrophages and lymphoblasts (the normal small lymphocyte having essentially no lysosomal organelles). The mononuclear cell infiltration characteristic of crude SRF and LNPF may proceed from their being contaminated with lymphotactin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972405
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  • 6
    Electronic Resource
    Electronic Resource
    Permeability factor contaminating hyaluronidase preparations (1979)
    Springer
    Inflammation 3 (1979), S. 447-451 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both crude and highly purified testicular hyaluronidase preparations have been shown to contain a component which increases the permeability of the microcirculation in rat skin. This permeability activity had an isoelectric point of 7.4 while hyaluronidase was 9.4. It also could be separated from hyaluronidase by acrylamide gel electrophoresis. The permeability factor was not inhibited by serum and may explain previous observations that hyaluronidase preparations decrease the ischemia and necrosis appropriate to experimental myocardial infarction in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00913502
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  • 7
    Electronic Resource
    Electronic Resource
    Pulmonary macrophage growth factor (1979)
    Springer
    Inflammation 3 (1979), S. 253-260 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary macrophage growth factor (MGF) can be purified from the “used” serum-free medium of cultures of mouse lung cells by concentration and dialysis over a 30,000-dalton Amicon ultrafilter and subjecting the retentate to isoelectric focusing. This yields a protein fraction with an isoelectric point of pH 4.2, which contains all the MGF activity. Upon electrophoresis of this fraction in analytical gels, one large and four small bands could be visualized. All bands were biologically active. This same “heterogenous” fraction ran as one band (mol wt 68,000) in SDS analytical gel electrophoresis, suggesting the ordered aggregation of this monomer. This was confirmed by reelectrophoresis of the first (and largest) band demonstrating the same 5-banded pattern as the initial material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00914182
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  • 8
    Electronic Resource
    Electronic Resource
    Bulk modulus and density of polyethylene to 30 kbar (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 10 (1972), S. 1631-1637 
    Details
    ISSN: 0449-2978
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The results of bulk modulus and density measurements on low-density polyethylene to 30 kbar are presented. From these data the pressure coefficient dTt/dp of the glass transition temperature is obtained, and a comparison is made with data calculated from Pastine's theoretical equation of state for polyethylene.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.160100901
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  • 9
    Electronic Resource
    Electronic Resource
    Migration and proliferation of diploid human fibroblasts following “wounding” of confluent monolayersSupported in part by grants-in-aid from the Army (Surgeon General's Office), Cystic Fibrosis Foundation and the National Institutes of Health (AM-08-8168). (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 74 (1969), S. 235-243 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Six diploid human fibroblast strains were grown in confluent monolayers. Holes were scraped in these monolayers and the number of cells proliferating into these “wounds” with time were determined. The migration and mitotic aspects of the proliferation of fibroblasts into these wounds were analyzed separately.Small amounts of undialysed or dialysed serum were essential for cell division but not migration. Saline extracts of skin could not substitute for serum in the medium. Neither zinc nor cupric ion at tolerable concentrations (10-5M) increased the rate of cell proliferation.Normal human fibroblasts did not immediately start to divide from confluency into the “wound” space. Their generation time was about 32-39 hours. Fibroblasts from patients with cystic fibrosis began to divide almost immediately into the “wounded” area. Their generation time was about 48 to 56 hours.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040740304
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  • 10
    Electronic Resource
    Electronic Resource
    Isolation, purification, and chemical characterization of the serum mitogen for diploid human fibroblastsSupported by a Contract from the U. S. Army Medical Research and Development Command, DADA 17-69-C-9142. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 81 (1973), S. 257-270 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We have found that diploid human fibroblasts, but not heteroploid human fibroblasts, stringently required serum for their multiplication. Using Diaflo ultrafiltration membrane units, isoelectric focusing and preparative gel electrophoresis, we have isolated and purified this mitogenic activity from mammalian sera. This electrophoretically homogeneous sialoprotein is 120,000 daltons in size, with an iso-electric point of pH 5.2-5.4; it is made up of two electrophoretically identical dimers weighing 57,000 each; it is thermostable and is inactivated by both trypsin and neuraminidase.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040810214
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