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  • 1
    Digitale Medien
    Digitale Medien
    Captopril enhancesin vitro human lymphocyte thymidine incorporation (1984)
    Springer
    Inflammation research 15 (1984), S. 525-528 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Angiotensin-converting enzyme activity is present in human sarcoid as well as murine schistosome granulomas. Inhibition of angiotensin-converting enzyme by captopril results in decreased granuloma size in animals. Since captopril is used clinically to treat hypertension, its effect on human lymphocyte thymidine incorporation was determined. It was found that 5 × 10−5 M and 10−4 M captopril enhances lymphocyte thymidine uptake induced by 25 μg/ml phytohaemagglutinin-P. This suggests that captopril can alter immunological reactivity in man and that angiotensin-converting enzyme may have an immunological function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01966767
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  • 2
    Digitale Medien
    Digitale Medien
    Interrupted pregnancy as an indicator of poor prognosis in T1, 2, N0, M0 primary breast cancer (1983)
    Springer
    Breast cancer research and treatment 3 (1983), S. 339-344 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; histology ; interrupted pregnancy ; prognosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We examined the records of women with primary breast cancer for a history of pregnancy and live births. The patients were all histopathologic T1, 2, N0, M0 white females, untreated post modified radical mastectomy. Patients with a history of interrupted pregnancies have a significantly shorter time to recurrence than those with normal pregnancy history. A trend toward a lower incidence of highly differentiated histological pattern is also observed in cancers from these patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01807586
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  • 3
    Digitale Medien
    Digitale Medien
    Tumor-associated prostaglandins in patients with primary breast cancer: Relationship to clinical parameters (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 331-337 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; clinical correlates ; prostaglandins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Determination of the levels of prostaglandin E2 (PGE2) and PGF2α were carried out using homogenized primary human breast tumors. Measurable levels of both prostaglandins were found in all but one tumor examined. In most samples, the absolute PGF2α level was higher than that of PGE2. Higher PGE2 levels are more often seen in postmenopausal women than in pre- or perimenopausal patients, though among postmenopausal women, PGE2 levels do not correlate with age. Thus, the ratio of PGF:PGE is higher in pre/perimenopausal women than in postmenopausal women. Differences in PGF2α do not appear to be associated with age or menopausal status. Tumors that are estrogen receptor positive (ER +) tend to have higher PGE2 levels than ER negative tumors. PGF2α is not associated with the presence of ER and neither prostaglandin is associated with the presence of progesterone receptor. Higher levels of both PGE2 and PGF2α are associated with less differentiated tumors, while tumor maximum diameter is negatively associated with PGE2 levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01805874
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  • 4
    Digitale Medien
    Digitale Medien
    Prognostic significance of serum IgE levels in primary breast cancer (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 221-226 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; IgE ; prognosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Serum IgE was measured in presurgical sera from 166 nonallergic women admitted to a comprehensive, multidisciplinary study of primary, operable breast cancer. During the follow-up period, which averaged 48 months, there were 71 recurrences. Patients were divided into two groups: those with IgE levels greater than the geometric mean value of 24 I.U. and those with levels less than the mean. The rate of tumor recurrence was significantly greater for the IgE 〉 24 group (p〈0.03). IgE remained a significant prognostic indicator when evaluated by Cox regression analysis in conjunction with other known prognostic factors including: number of positive lymph nodes, clinical stage, menopausal status, estrogen receptor status, mitotic grade, tumor diameter, breast feeding history, and age of patient (p〈0.015). IgE was not correlated with any of these known prognostic factors in individual analyses. We conclude that serum IgE level is a significant, independent prognostic indicator in primary breast cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01806934
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  • 5
    Digitale Medien
    Digitale Medien
    Relationship of natural killer cytotoxicity to clinical and biochemical parameters of primary human breast cancer (1984)
    Springer
    Breast cancer research and treatment 4 (1984), S. 109-116 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; clinical correlates ; natural killer activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have determined the natural killer (NK) activity of peripheral blood lymphocytes obtained from 121 women undergoing surgery for primary breast cancer. NK activity was measured using51Cr-labeled K562 target cells and effector: target ratios of 100:1, 50:1 and 10:1. The patients' lymphocytes gave a wide range of values with a mean (± S.E.) cytotoxicity of 22.6% ± 1.3, and a median of 20.9% at the 50:1 effector:target ratio. These results did not differ significantly from the mean and median NK levels obtained with the peripheral blood lymphocytes of normal blood donors (mean = 23.1% ± 1.9, median = 18.8%). Mean NK activity determined at the first postsurgical examination (⩽6 months postoperative) was significantly lower than the mean NK activity at surgery. The most significant decreases were seen in patients undergoing chemotherapy prior to the first follow-up examination. Subsequent tests (〉6mo,⩽12 mo) show a recovery of NK activity to preoperative levels. A negative correlation was seen between NK level and maximum tumor diameter. NK levels also varied with tumor histiotype. No association was seen between NK levels and either the number of involved lymph nodes, pathologic tumor grade, the presence of estrogen or progesterone receptor, or the age, menopausal status or smoking history of the patients. A positive correlation was seen, however, between NK levels and number of pregnancies and live births.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01806393
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