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  • 1
    Electronic Resource
    Electronic Resource
    Bingley : Emerald
    Nutrition & food science 95 (1995), S. 12-16 
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Fish oil contains uniquely high amounts of n-3 (or omega-3)polyunsaturated fatty acids (PUFAs). N-3 PUFA-rich diets are associatedwith suppression of the immune system, and populations which have highdietary intakes of fish, such as Greenland Eskimos, have a low incidenceof inflammatory and autoimmune disorders. These observations have led toa growing interest in the potential use of n-3 PUFAs as anutritionally-based approach to the treatment of rheumatoid arthritis,psoriasis and other inflammatory disorders. Although fish oils may notbe as effective as either steroidal or non-steroidal anti-inflammatorymedications, they may prove useful in reducing the dosage (andassociated side-effects) of these medications required to bring aboutclinical benefit. A greater understanding of the mechanisms by whichfish oil affects immune function should aid in improving its efficacy inthe treatment of over-reactive immune disorders.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 355-357 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 369 (1994), S. 187-188 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN bacterial cells, histidine kinases are big players in mediating responses to diverse environmental signals through changes in gene expression and cell behaviour. These kinases were thought to be confined to prokaryotic cells, until late last year when putative histidine kinases were identified ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 364 (1993), S. 349-352 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mammalian MAP kinase kinase (MAPKK) is 55% identical in amino-acid sequence to S. pombe Byrl in the catalytic domain and 38% identical overall. This suggested that MAPKK might be able to complement the byrl mutant defect. To test this, a rabbit MAPKK cDNA driven by a fission yeast promoter ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 11 (1997), S. 477-480 
    ISSN: 1432-198X
    Keywords: Key words: Henoch-Schönlein purpura ; Complement activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The pathogenetic mechanism underlying Henoch-Schönlein purpura (HSP) is poorly understood. Complement activation has been thought to have a role, but despite the demonstration of complement components in skin and renal biopsy material, serological evidence of complement activation is not convincing. We have assessed complement activation in 64 children with acute HSP. We used an enzyme-linked immunosorbent assay to measure plasma levels of three multimolecular complement activation protein (CAP) complexes: C1r: C1s: C1-inhibitor, C3bP and C5b-9. We found no significant difference between the levels of CAPs in children with acute HSP and a control group of children. This study does not support a role for complement activation in the pathogenesis of HSP.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-198X
    Keywords: Key words: Haemolytic uraemic syndrome ; Neutrophil ; Oxidative burst ; Elastase ; Chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract . Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome (D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques. Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral blood neutrophil.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1617-4623
    Keywords: Cell cycle ; Mitosis ; Fission yeast ; cdc27 +
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The cell division cycle gene cdc27 + of the fission yeast Schizosaccharomyces pombe is required for the transition from G2 into mitosis. Genetic and physiological experiments suggest a close relationship between cdc27 + and the cdc2 + gene, a key regulator of mitosis in yeast and also in higher eukaryotic cells. We isolated the cdc27 + gene by complementation of a temperature-sensitive cdc27 mutant. The DNA sequence of this gene predicts a 1116 nucleotide open reading frame split by five short introns, ranging in size from 49 to 74 nucleotides. Analysis of cDNA clones confirmed the structure of the gene. The deduced cdc27 + gene product consists of 372 amino acids with a predicted Mr of 43 kDa. No homology of the predicted protein with known proteins could be found, thus the cdc27 + gene encodes a novel function required for the G2-M transition. Northern analysis revealed two mRNAs of 1.4 and 2.2 kb transcribed from this gene, the smaller transcript being approximately tenfold more abundant than the larger. The level of cdc27 + mRNAs remained constant through the cell cycle indicating that the time of action of the cdc27 + gene, which is known to be regulated by elements of the mitotic control, is not determined by periodic accumulation of its transcripts.
    Type of Medium: Electronic Resource
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