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  • 1
    Electronic Resource
    Electronic Resource
    La microscopie confocale: interet pour l'analyse du relief cutané. Un outil d'évaluation dermo-cosmétique (2002)
    Oxford, UK : Blackwell Science, Ltd
    International journal of cosmetic science 24 (2002), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nowadays, the determination of human skin microtopography is usually carried out by methods based on mechanical techniques (profilometry and surfometry), or founded on optical conception (shadowing method and profilometry). Negative skin replicas made of a silicone rubber material (Silflo®) or positive casts performed from an epoxy resin (Araldite®), are used to assess the skin microstructure. Skin surface microtopography is quantified by measuring furrows depths and spaces between them. An original application using confocal scanning laser microscope (CLSM) is described in this paper. The CLSM gives simultaneously images of the skin surface associated with quantitative measurements of the microtopography. With this apparatus, it is easy to achieve perfect skin replica images with assessment of its microstructure, before and after applications of topical medicines or cosmetic products to evaluate the skin surface restoration. It is worth to mention that it is indispensable to analyse the same skin surface (same plateaux and same furrows). For this reason, it is necessary to localize exactly and to replicate the same skin surface area (4 mm2) before and after the cosmetic use, whatever the extended period of the topical application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1467-2494.2002.00165.x
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  • 2
    Electronic Resource
    Electronic Resource
    A new method to measure in vivo human skin hydrophobia (2001)
    Oxford, UK : Blackwell Science, Ltd
    International journal of cosmetic science 23 (2001), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Until now, the wettability of the skin has been only estimated through the measurement of its critical surface tension (Zisman), or surface free energy. These methods give information on the behaviour of the surface with water, but cannot quantify its behaviour with other polar liquids.In this paper we propose to express both the hydrophilia of the skin (Hi) by the ratio of its critical surface tension (γc) to the water surface tension (γH2O), and its hydrophobia (Ho) by the ratio of the difference between the critical surface tension (γc), and the value of the water surface tension (γH2O) normalized by the latter. By using this proposed parameter, it should be possible to classify skin surfaces according to their affinities to water, which is of major importance in Cosmetology as well as in biology. We also discuss the relationship between surface hydrophilia (Hi) and polarity (P) as defined by Wu, and water adhesion tension (τo) as described by Vogler.The γc of untreated skin was 27.3 ± 3.6 mJ m−2, confirming previous data, and consequently basal Hi was 38%. Either cleaning with ether or hydration by occlusion induced a diminution of the wetting capacity of the surface and consequently a decrease of Hi to 29% and 33%, respectively. In contrast, washing the skin surface with soap and water increased surface Hi to 43%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0412-5463.2001.00108.x
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  • 3
    Electronic Resource
    Electronic Resource
    Eosinophilic pustular folliculitis in infancy: report of two affected brothers (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe two brothers with eosinophilic pustular folliculitis. Both had recurrent crops of papules and pustules, primarily affecting the scalp. The eruption began in the neonatal period. Both children had a leucocytosis with eosinophilia.Histology revealed folliculitis, with an infiltrate in which eosinophils were predominant. Bacteriological and fungal cultures of pustules were negative. There was a good clinical response to treatment with a topical corticosteroid and dapsone.We review the 28 previously reported cases of eosinophilic pustular folliculitis in infancy. The occurrence of this disorder in brothers suggests that an inherited or contagious factor may be involved in its aetiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb05031.x
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  • 4
    Electronic Resource
    Electronic Resource
    Spectrum of cross-photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen: associated photoallergies to non-benzophenone-containing molecules (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 48 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2·5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2003.00066.x
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  • 5
    Electronic Resource
    Electronic Resource
    Allergic contact dermatitis to Zovirax® cream (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb02122.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Spectrofluorimetric determination of 5-methoxypsoralen pharmacokinetic in patients' serum (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 6 (1997), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract In medicine, psoriasis and vitiligo are most often treated with PUVA therapy (psoralen plus ultraviolet A). The determination of psoralen in patients' blood is necessary, as it is admitted that the therapecutic efficiency depends on drug concentration in patients' serum. The amount of UVA to administer is inversely proportional to serum peak concentration. High performance liquid chromatography (HPLC) and gas chromatography are the most employed methods for determining psoralens in patients' serum. The 2 techniques are precise and very sensitive, but time consuming. The aim of this paper is to propose a suitable method which is rapid and simple. It is a spectrofluorimetric technique for 5-methoxypsoralen (5-MOP) determination in the serum of patients treated with PUVA therapy. 5-MOP extraction was carried out with an heptane/dichloromethane mixture (4/1; v/v), according to the Stolk method (1980). A calibration curve (CC) was plotted from 5-MOP concentrations (range 50, 100, 200, 300, 400, 500 ng/ml). The CC was linear with a good coefficient of correlation: r= 0.9971, and a suitable coefficient of variation (CV) of 7.0%. The recovery of the method ranged from 85.3±4.2 to 108±4.1%/. The assay precision gave a CV ranging from 0.10 to 6.90%, with an error inferior to ± 10%. The method did not reveal any interference from serum components on the 5-MOP emission wavelength. The limit of detection of 5-MOP was 15 ng/ml. The proposed procedure was proved to be appropriate for a rapid determination of 5-MOP in patients' serum. This technique could also be employed for other proralens used in PUVA therapy (e.g., 8-methoxypsoralen.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1997.tb00147.x
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  • 7
    Electronic Resource
    Electronic Resource
    Post-traumatic diabetes insipidus and amenorrhea-galactorrhea syndrome after pituitary stalk rupture (1987)
    Springer
    Neuroradiology 29 (1987), S. 299-300 
    Details
    ISSN: 1432-1920
    Keywords: Post traumatic diabetes insipidus ; Amenorrhea ; Galactorrhea syndrome ; CT scan ; Pituitary stalk rupture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451773
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  • 8
    Electronic Resource
    Electronic Resource
    Peak blistering point: influence on fluid levels of 5-MOP in human skin in vivo after systemic administration (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 297-299 
    Details
    ISSN: 1432-069X
    Keywords: 5-Methoxypsoralen ; Suction blister fluid ; Pharmacology ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The concentration of 5-methoxypsoralen (5-MOP) in suction blister fluid (SBF) after oral intake was determined in relation to the peak blistering point. Interstitial fluid was obtained from nine healthy male volunteers by applying mild suction (300–350 mmHg) to the skin of the volar aspect of the forearm. Blisters were raised at three different times: 18 h prior to drug administration (group I); 2 h prior to drug administration (group II); and during drug ingestion (group III). SBF levels of 5-MOP were determined in each group of blisters 2 h after oral administration of 1.2 mg/kg micronized 5-MOP. The results showed a statistically significant difference in the concentrations of 5-MOP between each group of blisters. The highest concentration of 5-MOP in the SBF was found in group III and the lowest in group II blisters. These findings suggest that the point of peak blistering in relation to drug administration needs to be known in each pharmacological study using suction blisters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376617
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  • 9
    Electronic Resource
    Electronic Resource
    Leukemia and Crohn's disease (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 1391-1391 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299820
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