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  • 1
    Electronic Resource
    Electronic Resource
    Clinical evaluation of whole-body 18F-fluorodeoxyglucose positron emission tomography in the detection of liver metastases (1998)
    Springer
    Annals of oncology 9 (1998), S. 397-401 
    Details
    ISSN: 1569-8041
    Keywords: cancer ; FDG ; liver metastasis ; PET
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Assessment of metastatic involvement of the liver remains a diagnostic challenge. The objective of this study was to evaluate the potential role of FDG PET in the detection of liver metastases. Patients and methods: Sixty-four patients with malignancy and possible liver involvement were included. Liver metastases were present in 31 cases, demonstrated by histopathological analysis in 15 cases and by follow-up in 16 cases. The negative cases were confirmed by pathology in four cases, peroperative ultrasonography in 12 cases, and follow-up in 17 cases. Whole-body FDG PET was compared to CT (n = 53) and US (n = 43). Results: PET demonstrated a 97% sensitivity, an 88% specificity and a 92% accuracy, compared to 93%, 75% and 85%, respectively, for CT (P = NS). Concordant results were obtained in 44 of 64 patients (69%; 19 TP, 25 TN). PET provided new and accurate information in 15 of 64 patients (23.4%). PET demonstrated liver metastases in 11 patients in whom conventional methods yielded negative (two cases) or doubtful (nine cases) results. Four patients free of liver involvement were correctly staged with PET, while CT/US were equivocal. PET was erroneous in five of 64 cases (7.8%, four FP, one FN). Conclusions: FDG PET allows an accurate screening of liver involvement in patients with malignancy. Combined with CT, it provides additional diagnostic information that could directly affect the management of these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008290027419
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  • 2
    Electronic Resource
    Electronic Resource
    Staging of non-small-cell lung cancer by whole-body fluorine-18 deoxyglucose positron emission tomography (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 204-206 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Fluorodeoxyglucose ; Lung neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue. We undertook a prospective study in 61 patients to compare the accuracy of whole-body FDG PET and conventional imaging (CI) methods for the staging of nonsmall-cell lung cancer (NSCLC). CI included chest and abdomen computed tomographic scanning and bone scintigraphy. When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or clinical or radiological follow-up. As compared to CI, PET correctly changed the N stage in 13 patients (21%) and the M stage in six patients (10%). There were three false-positive and no false-negative distant PET findings. Our preliminary results show that whole-body FDG PET can improve the diagnostic accuracy in the staging of NSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731846
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 1641-1674 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Fluorine-18 fluorodeoxyglucose ; Oncology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and follow-up. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249629
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  • 4
    Electronic Resource
    Electronic Resource
    Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial (1998)
    Springer
    European journal of nuclear medicine 25 (1998), S. 375-385 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Technetium-99m methoxyisobutylisonitrile ; Scintimammography ; Breast cancer ; Dense breasts ; Mammography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of the trial was to determine the diagnostic accuracy of scintimmammography with technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) in the detection of primary breast cancer and to verify its clinical usefulness. A total of 246 patients with a suspicious breast mass or positive mammogram were included in this prospective European multicentre trial. At 5 min and 60 min (optional) p.i. two lateral prone images were acquired for 10 min each; 30 min p.i. one anterior image was acquired for 10 min. There were 253 lesions (195 palpable and 58 non-palpable), in respect of which histology revealed 165 cancers and 88 benign lesions. Institutional and blinded read results were correlated to core laboratory histopathology results obtained during excisional biopsy. Diagnostic accuracy for the detection of breast cancer was calculated per lesion. The overall sensitivity and specificity of blinded read scintimammography were 71% and 69%, respectively. For palpable lesions, the sensitivity of blinded read and institutional read scintimammography was 83% and 91%, respectively. Sensitivity was not dependent on the density of the breast tissue. Invasive ductal and invasive lobular cancers showed similar sensitivity. The sensitivity and specificity of mammography were 91% and 42%, respectively, and did not depend on the tumour size. In 60% of false-negative mammograms, 99mTc-MIBI was able to diagnose malignancy (true-positive). High-quality imaging with 99mTc-MIBI has a high diagnostic accuracy for the detection of primary breast cancer. Used as a complementary method, scintimammography with 99mTc-MIBI can help to diagnose breast cancer at an earlier stage in patients with dense breasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050235
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    Paper (German National Licenses)
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