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  • 1
    Electronic Resource
    Electronic Resource
    The effects of sevoflurane and desflurane in vitro on platelet–leukocyte adhesion in whole blood (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The interaction between platelets and leukocytes plays an important role in inflammatory and thrombotic processes. We investigated whether the volatile anaesthetics sevoflurane and desflurane alter the formation of platelet–leukocyte aggregates and the expression of P-selectin on platelets. Whole blood was incubated with 1 and 2 minimum alveolar concentration (MAC) sevoflurane or desflurane. Unstimulated and adenosine diphosphate, or thrombin receptor agonist peptide-6-stimulated samples were stained with flourochrome-conjugated antibodies. The formation of platelet–leukocyte conjugates and the expression of P-selectin on platelets were measured using flow cytometry. Sevoflurane was found to enhance the binding of platelets to lymphocytes, neutrophils and monocytes, it also increased the expression of P-selectin on platelets especially in the stimulated samples. Desflurane decreased the percentage of lymphocyte–platelet, neutrophil–platelet and monocyte–platelet conjugates principally in unstimulated samples. The results show that these two volatile anaesthetics have differing effects on the formation of platelet–leukocyte conjugates in vitro. Sevoflurane also enhanced the expression of P-selectin on platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03076.x
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  • 2
    Electronic Resource
    Electronic Resource
    Transfusionsgesetz (2000)
    Springer
    Der Anaesthesist 49 (2000), S. 861-866 
    Details
    ISSN: 1432-055X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Gesetz zur Regelung des Transfusionswesens [1] (Transfusionsgesetz – TFG) ist mit Ausnahme der §§ 15 TFG “Qualitätssicherung und 22 ”Epidemiologische Daten&” am 07.07.1998 in Kraft getreten. Ziel des Gesetzes ist es, Risiko von den spendenden und den zu behandelnden Personen bei der Gewinnung von Blut- und Blutbestandteilen und der Anwendung von Blutprodukten einschließlich Eigenblut fernzuhalten und die Selbstversorgung mit Blut und Blutprodukten zu fördern. Mit Inkrafttreten des Gesetzes wurde durch den § 34 TFG eine erhebliche Änderung des Arzneimittelgesetzes (AMG) in den §§ 14 und 15 bzgl. der Erteilung der Erlaubnis zur Herstellung von Blutzubereitungen vollzogen, u. a. die Erfordernis der “Kleinen Herstellungserlaubnis” bei der autologen Blutzubereitung. § 134 wurde als Übergangsvorschrift dem AMG hinzugefügt. In diesem Kontext wurden ebenfalls die Betriebsverordnung für pharmazeutischen Unternehmer (§ 35 TFG), die Apothekenbetriebsverordnung (§§ 36, 37) und die Betriebsverordnung für Arzneimittelgroßhandelsbetriebe geändert (Verpflichtung zur produktbezogenen Chargendokumentation, Datenschutz).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010070062
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Severe Cytomegalovirus-Triggered Autoimmune Hemolytic Anemia Complicating Vertically Acquired HIV Infection (2000)
    Springer
    European journal of clinical microbiology & infectious diseases 19 (2000), S. 57-60 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The association of acute cytomegalovirus infection with severe autoimmune hemolysis has not yet been reported in patients with HIV infection. The case is described of a 9-month-old infant with congenital HIV-1 infection who presented with severe autoimmune hemolysis and a high cytomegalovirus viral plasma load. Alternative causes of the hemolysis, such as drugs or other infections, were ruled out. After birth and after successful therapy of hemolysis, cytomegalovirus was not detected in the plasma, strongly suggesting a causal relationship between the hemolysis and cytomegalovirus infection. Severe autoimmune hemolysis should thus be considered as a cytomegalovirus-associated complication in HIV infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050012
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    Paper (German National Licenses)
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