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  • 1
    Electronic Resource
    Electronic Resource
    Cell biology: Rheumatoid sera unravel microtubule organizers (1984)
    [s.l.] : Nature Publishing Group
    Nature 308 (1984), S. 604-605 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE complex arrays of microtubules in cultured cells, revealed so spectacularly in recent years by techniques of immunofluorescence, are organized by two types of cellular structure, the centrosome and the kinetochore. Both will nucleate the assembly of microtubules in vitro, although it is still ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/308604b0
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  • 2
    Electronic Resource
    Electronic Resource
    A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 412 (2001), S. 352-355 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The accurate segregation of chromosomes at mitosis depends on a correctly assembled bipolar spindle that exerts balanced forces on each sister chromatid. The integrity of mitotic chromosome segregation is ensured by the spindle assembly checkpoint (SAC) that delays mitosis in response to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35085604
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  • 3
    Electronic Resource
    Electronic Resource
    ABG of microtubule assembly (1991)
    [s.l.] : Nature Publishing Group
    Nature 352 (1991), S. 471-471 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RESOLUTION of the long-standing uncertainty over how the polar assembly of microtubules in living cells is organized has come a step nearer with the publication of two papers in Cell1'2. Zheng et al.1 and Stearns et aL2 have discovered that the newest member of the tubulin superfamily, y-tubulin, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/352471a0
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  • 4
    Electronic Resource
    Electronic Resource
    Cell biology: Baseless flagellation (1985)
    [s.l.] : Nature Publishing Group
    Nature 314 (1985), S. 401-401 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] COMPARED with its enigmatic alter ego, the centriole, the basal body is a fairly straightforward organelle. Basal bodies sit, appropriately, on the base of eukaryotic cilia and flagella. Unlike the structures associated with the base of bacterial flagella, they are not actively involved in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/314401a0
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  • 5
    Electronic Resource
    Electronic Resource
    Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast (1990)
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 680-682 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have previously shown that cdc!3 in S. pombe increases in abundance during interphase (Fig. la, b) and disappears rapidly at mitosis7'8. A more detailed investigation of the early stages of mitosis revealed the presence of two bright dots of cdc!3 fluorescence at the nuclear periphery (Fig. Ic). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/347680a0
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  • 6
    Electronic Resource
    Electronic Resource
    Many routes lead to the pole (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 484-484 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MICROTUBULES in cells do not arise at random. Rather, their organization into arrays such as the mitotic spindle is choreographed by structures known as microtubule organizing centres, which were first recognized over 20 years ago1, and which influence the dynamic properties and structural ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348484a0
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  • 7
    Electronic Resource
    Electronic Resource
    Retrograde step for microtubules (1987)
    [s.l.] : Nature Publishing Group
    Nature 330 (1987), S. 106-106 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LOOKING at a living cell through the microscope is a bit like having a bird's eye view of Piccadilly Circus in rush hour. Vesicles and organelles show a complex two-way traffic pattern along intracellular highways of microtubules radiating out from the nucleus. Movement is either outwards ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/330106a0
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  • 8
    Electronic Resource
    Electronic Resource
    Firm base for basal body DNA (1989)
    [s.l.] : Nature Publishing Group
    Nature 341 (1989), S. 485-486 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BASAL bodies and their alter ego the centriole are amongst the most enigmatic cell organelles1. They seed the growth of flagella and cilia, they have a complex pin-wheel structure (see figure), they can undergo Jeckyll and Hyde-like inter-conversion at specific points in the cell cycle and, most ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/341485a0
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  • 9
    Electronic Resource
    Electronic Resource
    Microtubules in the fission yeast Schizosaccharomyces pombe contain only the tyrosinated form of α-tubulin (1991)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 18 (1991), S. 86-93 
    Details
    ISSN: 0886-1544
    Keywords: tubulin ; detyrosination ; cdc mutants ; D2O ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The state of tubulin tyrosination in the fission yeast Schizosaccharomyces pombe was investigated using a combination of indirect immunofluorescence microscopy and Western blotting. Antibodies specific for the tyrosinated form of α-tubulin stained all microtubule arrays in wild type cells and recognised the two α-tubulin polypeptides in Western blots of cell extracts enriched for tubulin by DEAE-Sephadex chromatography. Antisera that specifically recognised the detyrosinated, glu, form, on the other hand, gave consistently negative results, both in cells undergoing rapid exponential growth and in those allowed to accumulate in stationary phase. Neither the “ageing” of microtubules, by arresting cells at different points (late G1 or G2/M) in the cell division cycle, nor stabilising them, using D2O, lead to any detectable tubulin detyrosination. These results suggest that S. pombe lacks the carboxypeptidase that carries out the tubulin detyrosination reaction. This is the first report of an organism that possesses the correct C-terminal α-tubulin sequence yet fails to carry out this post-translational modification. The implication of this novel finding for the biological role of these events is discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970180203
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  • 10
    Electronic Resource
    Electronic Resource
    The mechanism of microtubule associated cytoplasmic transport (1979)
    Springer
    Cell & tissue research 196 (1979), S. 103-116 
    Details
    ISSN: 1432-0878
    Keywords: Cytoplasmic transport ; Microtubules ; Insect ovary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The nutritive tubes of telotrophic insect ovaries are cytoplasmic channels along which ribosomes are transported over distances of several mm from trophic cells to the developing oocytes. The presence within the nutritive tubes of a massive number of orientated microtubules renders them strongly birefringent in polarised light, a property which, together with their size, rendered them amenable to isolation by microdissection. Ultrastructurally the isolated tubes were indistinguishable from undissected controls. Polyacrylamide gels revealed a consistent pattern of some 30 bands of which tubulin was the most prominent. The tubes also contained a band which comigrated with the major high molecular weight micro tubule associated protein (MAP) from mouse brain but no detectable actin, myosin or dynein. Microtubules in the isolated tubes were not depolymerised by treatments (cold, calcium and colchicine) which typically disrupt cytoplasmic microtubules. Following extraction of the membrane enclosing the tubes and the cytoplasmic matrix the microtubule cytoskeleton persisted, retaining its cylindrical organisation although no bridges between the microtubules were detected in the electron microscope. The possibility that the stability and spatial deployment of the nutritive tube microtubules is conferred by specific microtubule accessory proteins is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236351
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