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  • 1
    Electronic Resource
    Electronic Resource
    A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 17 (2002), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Objective: The effects of volume reduction surgery (VRS) for ischemic cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. Methods: Study 1 (Noninvasive study): Twenty-six rats developed large akinetic left ventricular (LV) aneurysms or ischemic cardiomyopathy after anterior descending artery ligation (first surgery). Four weeks after the surgery, 13 rats underwent volume reduction surgery (second surgery) (VRS group), while 13 underwent rethoracotomy alone (sham group). Before the first surgery, and before and after the second surgery, the LV dimensions were measured by echocardiography, and the heart rate and systolic blood pressure were recorded by the tail cuff method. Study 2 (Invasive study): In 7 rats undergoing the VRS and 9 undergoing the sham operation, LV pressure was measured with a manometer-tipped catheter, immediately before and after the second surgery. Results: Study 1: All rats survived the second surgery, after which LV end-diastolic diameter decreased and LV fractional shortening increased (both p 〈 0.001) in the VRS group. This group also increased heart rate after the second surgery (p 〈 0.05). Study 2: There were no differences in LV endsystolic or end-diastolic pressure between the two groups before and after the second surgery. Conclusions: This model enables reproducible physiological evaluation of the LV after VRS, and since the rats show postoperative survival, it provides a useful tool for various investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2002.tb01191.x
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  • 2
    Electronic Resource
    Electronic Resource
    Early and Mid-Term Results of Left Ventricular Volume Reduction Surgery for Dilated Cardiomyopathy (2005)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 20 (2005), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Objective: To evaluate structure-oriented left ventricular volume reduction surgery (LVVRS). The purpose of this study was to report the early and mid-term results of left volume reduction surgery for dilated cardiomyopathy (DCM). Methods: We performed LVVRS on 29 patients with DCM. The age of the patient ranged from 8 to 73 years (mean 58 ± 18 years). There were 19 male patients (63%). Twenty-three patients were ischemic, 5 were non-ischemic, and 1 had salcoidosis. Twenty-three patients were in New York Heart Association class III or IV. Fourteen patients underwent the Dor operation, 11 underwent a septal anterior ventricular exclusion operation, and 6 underwent a modified Batista operation. Fifteen patients underwent mitral annuloplasty and 2 patients had mitral valve replacement. All patients were divided into two groups, a Dor group (n = 14) and non-Dor group (n = 15). Postoperative early results and mid-term survival rate were compared between the two groups. Results: Hospital mortality was 13.8% (4/29). The causes of death were low-output syndrome (n = 3) and septic shock (n = 1). Survival rate was 80% at 1 year and 72% at 3 years. Two-year survival rate of Dor and non-Dor groups were 69.8% and 93.8%, respectively (p = 0.099). Conclusions: Early and mid-term results of LVVRS were satisfied, and the non-Dor operation tended to be superior in mid-term survival to the Dor operation. Long-term follow-up is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2005.0156a.x
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  • 3
    Electronic Resource
    Electronic Resource
    A Rat Model of Dilated Cardiomyopathy to Investigate Partial Left Ventriculectomy (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 16 (2001), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: This study is the first to assess a small animal model of dilated cardiomyopathy (DCM) for evaluation of partial left ventriculectomy. Method: Eighteen Dahl salt-sensitive (DS) rats were divided into three groups. Six rats were fed an 8% high-salt diet from the age of 7 weeks (Group 1), and similarly six rats from 8 weeks (Group 2) and six from 9 weeks (Group 3). Blood pressure (BP) was measured by the tail-cuff method and left ventricular (LV) dimensions by echocardiography. Results: In Groups 1 and 2, systolic BP rose and reached 200 mmHg by the 10th to 11th week, when all rats died within a week without signs of heart failure. However, in Group 3, systolic BP gradually rose to 196 ± 15 mmHg (mean ± SD) at the age of 14 weeks, when LV end-diastolic diameter (EDD) was 6.2 ± 0.4 mm (control 5.1 ± 0.7 mm) and LV fractional shortening (FS) was 77 ± 3% (control 68 ± 3%). At the age of 25 to 30 weeks, all rats in Group 3 showed signs of congestive heart failure, systolic BP remained high, EDD markedly increased (8.7 ± 0.6 mm), and LVFS decreased (38.9 ± 8.1%). From this stage, rats survived for 13.7 ± 5.9 days. We employed the Group 3 model for our pilot PLV study. Eight rats had PLV with a beating heart by plicating the LV area between the papillary muscle bases. Two rats died perioperatively but the rest survived (60% survival 3 weeks after PLV). Postoperatively, the rats' LVEDD decreased and FS improved significantly. Conclusions: Using DS rats, we developed a DCM model for investigating PLV. The model may contribute to scientific investigation of PLV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2001.tb00482.x
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  • 4
    Electronic Resource
    Electronic Resource
    0.3-μm-diam bubble material of (BiSmLu)3(FeSc)5O12 grown from PbO-Bi2O3-V2O5 flux (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 3485-3487 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Garnet films of (BiSmLu)3(FeSc)5O12 supporting 0.3-μm-diam bubbles have been grown on Nd3Ga5O12 substrates by liquid-phase epitaxy using PbO-Bi2O3-V2O5 flux. The uniaxial anisotropy energy in the films can be increased by adding V2O5 to the PbO-Bi2O3 flux. The anisotropy energy of 0.3-μm-diam bubble material of (BiSmLu)3(FeSc)5O12 grown from PbO-Bi2O3-V2O5 flux was 2.9×105 erg/cm3. This value is greater than that of the 0.3-μm-diam bubble material grown from PbO-Bi2O3 flux by about 45%. The content of Bi in the film is increased by adding V2O5 to the PbO-Bi2O3 flux. The increase in the anisotropy energy is considered to be caused by this increase in Bi content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338733
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis and interactive properties of an oligonucleotide with anthraquinone at the sugar fragment (1990)
    s.l. : American Chemical Society
    Bioconjugate chemistry 1 (1990), S. 319-324 
    Details
    ISSN: 1520-4812
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bc00005a004
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  • 6
    Electronic Resource
    Electronic Resource
    De novo glucan synthesis by mutans streptococcal glucosyltransferases present in pellicle promotes firm binding of Streptococcus gordonii to tooth surfaces (1992)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 96 (1992), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Adherence of 3H-labelled cells of Streptococcus gordonii and Streptococcus milleri to artificial pellicles prepared from saliva supplemented with glucosyltransferases from mutans streptococci was examined using a new assay for sucrose-dependent cell-to-pellicle attachment. Results indicate that S. gordonii, but not S. milleri, could attach tightly to hydroxylapatite surfaces through de novo glucan synthesis by mutans streptococcal glucosyltransferases present in the experimental salivary pellicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05415.x
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  • 7
    Electronic Resource
    Electronic Resource
    A sentinel node biopsy in breast cancer patients (1999)
    Springer
    Surgery today 29 (1999), S. 197-199 
    Details
    ISSN: 1436-2813
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02483005
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  • 8
    Electronic Resource
    Electronic Resource
    The effects of estrogen on human breast carcinomas serially transplanted into nude mice (1989)
    Springer
    Surgery today 19 (1989), S. 718-725 
    Details
    ISSN: 1436-2813
    Keywords: estrogen ; nude mouse ; hormone dependency ; human breast carcinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect and mechanisms of 17β-estradiol (E2) on breast cancer cells were studiedin vivo andin vitro, using 5 human breast carcinomas serially transplanted into nude mice. These carcinoma strains consisted of 4 estrogen receptor (ER) positive tumors and 1 ER negative tumor. Mice bearing these tumors were treated with an intramuscular injection of E2 at a dosage of 50 mg/kg and the tumor doubling time (Td) was calculated in days. The tumor growth was significantly stimulated by E2 in 3 out of the 4 ER positive tumors, the Td of the E2 treated groups being 17.6 days for MCF-7 (control: −17.8 days), 12.8 days for R-27 (control: −12.5 days∼14.5 days) and 10.4 days for Br-10 (control: 14.5 days), however, in the T-61 tumor, the growth was inhibited by E2 in a dose dependent manner. In the case of the ER-negative MX-1 tumor, the tumor cell growth was not affected by E2. Discrepancies between the effects of E2 on ER-positive tumors were further analyzed by examining the steroid hormone receptor status and conductingin vitro growth studies.In vitro clonogenic cell assay reproduced the antitumor activity of E2, indicating that E2 directly inhibits part of the cell growth of T-61 tumors. The above results suggest that this experimental system provides a useful tool for analyzing the mechanism of estrogen in breast cancer and that the clonogenic assay using ER positive specimens can help to identify breast cancers sensitive to estrogen therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471723
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  • 9
    Electronic Resource
    Electronic Resource
    Frozen-section-guided breast-conserving surgery: Implications of diagnosis by frozen section as a guide to determining the extent of resection (1997)
    Springer
    Surgery today 27 (1997), S. 207-212 
    Details
    ISSN: 1436-2813
    Keywords: breast cancer ; breast conserving surgery ; surgical margin ; frozen section ; local recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was conducted to analyze retrospectively the results of performing sector resection on 56 breasts in 54 patients with breast cancer. The glands were resected with a 2-cm tumor-free margin on both lateral sides and the distal side, and with more than a 3-cm tumor-free margin on the nipple side. The frequency of positive resection margins for the cancer cells was 7/56 (12.5%) on the nipple side and 12/46 (26.1%) on the lateral sides, with an overall frequency of 15/56 (26.8%). There were positive resected margins for cancer cells on both the nipple and lateral sides in 4/46 patients (9%) Assuming the equivocal margins were positive for cancer cells, an accurate diagnosis by frozen section examination was made in 51 of the 56 operations (91.1%). Additional resection of the margins was performed in all 20 cases of a positive resected margin for cancer cells according to the diagnosis by frozen section. Thereafter, the resected margins became negative in 13 cases (65%), but remained positive in 7 cases (35%). These results show that performing diagnosis by frozen section of the surgical margins is an effective guide to resecting tumors adequately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941646
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  • 10
    Electronic Resource
    Electronic Resource
    Effectiveness of an adriamycin immunoconjugate that recognizes the c-erbB-2 product on breast cancer cell lines (1996)
    Springer
    Surgery today 26 (1996), S. 501-507 
    Details
    ISSN: 1436-2813
    Keywords: Adriamycin ; breast cancer ; c-erbB-2 ; immunoconjugate ; targeting therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adriamycin (ADM) was chemically conjugated to a murine monoclonal antibody, A0011, which recognizes the c-erbB-2 product, via a disulfide bond using N-succinimidyl-3-(2-pyridyldithio) propionate (SPDP) and 2-iminothiolane (2-IT). The molar ratio of ADM to the monoclonal antibody ranged from 15:1 to 25:1 and enzyme-linked immunosorbent assay (ELISA) showed that the binding activity of the conjugate was almost retained. We compared the efficacy of A0011 alone, ADM alone, the A0011-ADM conjugate, and a nonspecific murine IgM-ADM conjugate, against the human breast cancer cell lines SK-BR-3, MDA-MB-361, MCF-7, and BT-20. The A0011-ADM conjugate was observed to be ten times more cytotoxic to the cell lines overexpressing the c-erbB-2 product, namely, SK-BR-3 and MDA-MB-361, than free ADM, but it showed weak cytotoxicity against the cell lines with a low level of c-erbB-2 product expression, namely, MCF-7 and BT-20. However, free A0011 and nonspecific murine IgM-ADM conjugate showed no cytotoxicity toward any of the four cell lines, while the addition of a tenfold molar excess of A0011 inhibited conjugate cytotoxicity. These data suggest that conjugate cytotoxicity is antibody-mediated. Moreover, conjugate cytotoxicity at 10−6M was correlated with antigen volume, and the data were fitted to the regression equation y=−11.63logX+116.38 where the correlation coefficient =0.950. Our results indicate that targeting therapy aiming at the c-erbB-2 product may be useful in the treatment of breast cancers overexpressing the c-erbB-2 product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311556
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