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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 95 (1988), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Metastatic gestational trophoblastic disease poses problems in diagnosis and management and has a poorer prognosis than the nonmetastatic variant. The lung is the most common site of metastases. This paper reviews 97 patients with pulmonary metastasis developing after gestational trophoblastic disease who were seen at one centre over 26 years. Most patients had an antecedent molar pregnancy but an associated choriocarcinomatous lesion in the uterus was absent in the majority. In many patients the pulmonary lesion was asymptomatic. Whilst chemotherapy was the treatment of choice, selective thoracotomy in cases with solitary lung nodules reduced the treatment time and need for aggressive multi-drug combination regimens. The overall survival rate at 2 years after diagnosis was 65%. A higher mortality was found when the antecedent pregnancy ended at term, when the time interval between the preceding pregnancy and diagnosis of pulmonary metastases was 〉 1 year, when multiple pulmonary secondaries were present or when cerebral metastases occurred. The main causes of death were cerebral haemorrhage, respiratory failure and pulmonary embolism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Prostaglandins 14 (1977), S. 615-616 
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1084
    Keywords: Ureteric structures ; Radical hysterectomy ; Interventional radiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following radical hysterectomy in 42 patients with early invasive carcinoma of the cervix, ureteric strictures developed in 7 patients. They were long, smooth strictures situated in the distal ureter and thought to be of benign origin, related to devascularisation of the ureter. All but one were diagnosed within 8 weeks of surgery and all were treated by a percutaneous approach using a combination of dilating catheters and ureteric stenting: a balloon catheter was used in one patient. In 5 patients treatment was successful. In 1 patient there was an equivocal result as she developed tumour recurrence at 8 months, while in another the procedure failed, probably because the stricture was not detected for 12 months and she had also had radiotherapy. The follow-up period ranged from 6 to 26 months (mean l5 months). Although previous workers have indicated that ureleric strictures following radical hysterectomy would not be expected to respond to transluminal dilatation, in view of the devascularisation of the ureter our experience shows that the majority of these partially devascularised ureters are amenable to percutaneous techniques if detected within 2–3 months of surgery.
    Type of Medium: Electronic Resource
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