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  • 1
    Electronic Resource
    Electronic Resource
    Granulocyte colony-stimulating factor-induced mobilization of peripheral blood stem cells for autologous and allogeneic transplantation (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S115 
    Details
    ISSN: 1432-0843
    Keywords: Key words PBSC ; Mobilization ; G-CSF ; Auto-PBSC transplantation ; Allo-PBSC transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Peripheral blood stem and progenitor cells (PBSC and PBPC), which circulate at very low levels during steady-state hematopoiesis, show a transient but marked increase during hematologic recovery from marrow-suppressive chemotherapy. To ensure rapid and sustained hematologic engraftment after autologous PBSC transplantation, sufficient PBSC or PBPC must be infused. To confirm the utility of granulocyte colony-stimulating factor (G-CSF) in chemotherapy-induced PBSC mobilization, we investigated the effect of G-CSF on PBSC mobilization in leukemia and lymphoma patients. The study design was such that PBSC mobilization with and without G-CSF was assessed in the same patients. The results indicate that PBSC mobilization can be enhanced significantly when G-CSF is given during the recovery phase postchemotherapy. Interestingly, progenitor cells of different lineages could be mobilized by G-CSF. We subsequently investigated the effect of increasing G-CSF dose on PBSC mobilization during steady-state hematopoiesis in healthy adult donors. The results indicate that not only committed but also primitive progenitor cells are mobilized into the circulation in a dose- and time-dependent manner when G-CSF at 5, 10, or 15 μg/kg was given on each of 5 days and leukapheresis was performed on day 6. From our data we estimate that sufficient PBSC for engraftment after allogeneic PBSC transplantation can be collected on day 5 of administration of G-CSF at 10 μg/kg and by 10-l leukapheresis on days 5 and 6. Furthermore, we found that some G-CSF-mobilized PBSC retained their self-renewal capability. These observations suggest that hematopoietic stem cells for allogeneic PBSC transplantation can be mobilized by short-term administration of relatively high-dose G-CSF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051051
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in plasma concentrations of free amino acids during and after the anhepaic period (1993)
    Springer
    Journal of anesthesia 7 (1993), S. 471-476 
    Details
    ISSN: 1438-8359
    Keywords: Amino acid ; Ketone body ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054030070471
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  • 3
    Electronic Resource
    Electronic Resource
    Rationale for preoperative screening of anti-HCV antibody (1993)
    Springer
    Journal of anesthesia 7 (1993), S. 27-32 
    Details
    ISSN: 1438-8359
    Keywords: Anti-HCV antibody ; HCV ; Needle-stick injury ; Blood-borne pathogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the incidence of the anti-HCV antibody and associated factors in 1,031 surgical patients who had received blood transfusion during or after operation from October 1988 to April 1991, at Kyushu University Hospital. One hundred fifteen patients (11.2%) were anti-HCV positive. Sixty of the 219 patients (27.%) with a history of transfusion were positive, as were 55 of 812 (6.8%) without it. Patients aged under 40 showed a 0.6% positive rate (1 of 175) as did 8.5% (54 of 637) of those 40 and over in the no transfusion history group. Among the 637 patients without transfusion histories and aged over 40, patients with preoperative maximum ALT value over 36 IU·l −1 had significantly higher positivity (16.0%, 29/181) than those with ALT values less than 35 IU·l −1 (5.5%, 25/456, P ≪ 0.01). The incidence of anti-HCV antibody in preoperative surgical patients in our hospital is ten times higher than that of donors. Anti-HCV are associated with transfusion, age, and liver dysfunction. Operating room personnel are at high risk because of contact with many HCV carrier patients. (Sakaguchi Y, Inaba S, Yoshitake J: Rationale for preoperative screening of anti-HCV antibody. J Anesth 7: 27–32, 1993)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054030070027
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in end-tidal CO2 level following tourniquet deflation during orthopedic surgery (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 9-15 
    Details
    ISSN: 1438-8359
    Keywords: Orthopedic surgery ; Pneumatic tourniquet ; End-tidal CO2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the changes in end-tidal CO2 (ETCO 2) and systemic responses after tourniquet deflation in spontaneously breathing and ventilation-controlled patients during orthopedic surgery of both the upper and/or the lower extremities. In most patients, increases in ETCO 2, heart rate, and PaCO 2, as well as decreases in blood pressure and pH were observed. In every spontaneously breathing patient, the respiratory rate began to increase before the ETCO 2 reached a maximum. Arterial blood gas analysis suggested that the increase in ETCO 2 closely reflected the increase in PaCO 2. Our study yielded new information on the ETCO 2 changes as follows: 1) the time for ETCO 2 level to reach a peak (peak time) was almost constant despite the considerable differences in the increases in ETCO 2 both in spontaneous breathing and ventilation-controlled groups and the peak time in the former group was shorter than that in the latter group; and 2) it was suggested that the increase in ETCO 2 in the spontaneously breathing patients was smaller than that in ventilation-controlled patients when both patients were subjected to the same conditions on tourniquet time and tourniqueted area. Our data showed that the increase in ETCO 2 (or PaCO 2) can be large and prolonged in some situations. Thus, we recommend continuous ETCO 2 monitoring and the proper hyperventilation at tourniquet deflation in order to minimize any adverse effects of acidosis. (Akata T, Tominaga M, Sagiyama M, et al.: Changes in end-tidal CO2 level following tourniquet deflation during orthopedic surgery. J Anesth 6: 9–16, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060009
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  • 5
    Electronic Resource
    Electronic Resource
    An increase in plasma concentrations of granulocyte elastase during and after bench surgery of the liver (1993)
    Springer
    Journal of anesthesia 7 (1993), S. 368-371 
    Details
    ISSN: 1438-8359
    Keywords: Elastase ; Granulocyte ; Liver ; Anhepatic period ; Reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054030070368
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  • 6
    Electronic Resource
    Electronic Resource
    Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 183-191 
    Details
    ISSN: 1438-8359
    Keywords: Anesthetics ; Volatile ; Halothane ; Enflurane ; Liver ; Hepatitis ; Drug toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidence of post-anesthetic mild liver disorder (PAMLD) was compared between 928 patients administered halothane and 1766 patients administered enflurane. They were selected from 19 504 surgical patients administered general anesthesia at Kyushu University Hospital over the past 6 years and 4 months. They had had normal liver function before operation and had no history of blood transfusion. Alanine aminotransferase (ALT) levels exceeding 70 IU·l −1 within 180 days after operation were found in 226 patients in the halothane group (24.4%), and in 250 patients in the enflurane group (14.2%) (P ≪ 0.01). Both maximum ALT levels and duration of ALT elevation were higher and longer in the halothane group (P ≪ 0.01). These results suggest that, not only in the development of fulminant hepatitis but also in PAMLD, enflurane is less hepatotoxic than halothane. (Sakaguchi Y, Inaba S, Umeki Y, et al.: Retrospective study of post-anesthetic mild liver disorder associated with inhalation anesthetics, halothane and enflurane. J Anesth 6: 183–191, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060183
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  • 7
    Electronic Resource
    Electronic Resource
    The Efficacy of Predeposited Autologous Blood Transfusions in General Pediatric Surgery (2000)
    Springer
    Surgery today 30 (2000), S. 773-777 
    Details
    ISSN: 1436-2813
    Keywords: Key Words Autologous blood transfusion ; Predeposition ; Allogeneic blood transfusion ; Pectus excavatum ; Choledochal cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Allogeneic blood transfusions are associated with a risk of infection, immunological reactions, immunosuppression, and the induction of antibodies in blood cells. We report our results of giving predeposited autologous blood transfusions (PABT) to children when it was anticipated that transfusions would be required for an elective operation. Autologous blood was collected for deposit from 16 patients ranging in age from 1 to 11 years old (mean 5.6 years old, mode 4 years old), and weighing from 9.7 to 42 kg (mean 20.8 kg). They included 12 patients with pectus excavatum (funnel chest) and 4 patients with choledochal cyst (CBD). Blood was collected once from 2 patients and twice from the other 14 patients, then centrifuged and stored in a freezer at −80°C. Between 7 and 14 ml/kg was collected at one time, the total mean volume of predeposited blood being 21.0 ± 3.3 ml/kg for the children operated on for funnel chest, and 16.2 ± 4.5 ml/kg for those operated on for CBD. None of the patients required allogeneic transfusions and no complications occurred. PABT was found to be a safe and effective means for elective general pediatric surgical procedures for avoidance of allogeneic blood transfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070057
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  • 8
    Electronic Resource
    Electronic Resource
    A pedigree of deficiency of the ninth component of complement (C9) (1983)
    Springer
    Journal of human genetics 28 (1983), S. 239-248 
    Details
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Findings in a large family with a hereditary deficiency of the ninth component of complement (C9) were reported. The proposita was a 64-year-old Japanese woman with gastric cancer. C9 was undetectable by both rocket immunoelectrophoresis and hemolytic assays. Despite the C9 deficiency her serum showed half the normal level of hemolytic complement activity (16 CH50 U/ml). C9 was not detectable in her two sisters who had no underlying disease. Other complement components were of normal levels in these two sisters. In 8 males and 7 females from three generations of the family, levels of C9 protein were reduced and ranged from 22 to 46% of the normal. Such corresponds to heterozygote for the mutant gene, and this defect may be due to autosomal incompletely dominant gene. The C9 deficient individuals were not liable to specific diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876786
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