ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Rabbit blastocysts in right uterine horns of 20 does were x-irradiated with 150 r or 200 r at 3.5 days of gestation, and compared with untreated litter-mates at 9.5 days. Irradiation increased pre-implantation mortality and significantly reduced average embryonic size. Mortality was 11.1% elevated in each group, but stunting increased with increased irradiation. At 150 r and 200 r respectively, 46.1% and 69.2% of irradiated embryos were smaller than the smallest litter-mate control. Large litter size caused almost 45% of the stunting in the 150 r group, but did not affect the 200 r group. In each group were some irradiated embryos of normal size, many stunted embryos, and a few grossly malformed and retarded. Moderate degrees of size reduction occurred less frequently among controls. In stunted embryos, experimental or control, the allantois usually failed to make uterine contact. Living irradiated embryos examined in utero frequently had areas of the yolk sac in which no blood could be seen. In both extra-embryonic and intra-embryonic vessels, their blood was distinctly paler than that of controls. Damage to hematopoietic tissue is probably a frequent result of prenatal irradiation. Stunting and allantoic retardation, which may contribute to the rabbit's normally high prenatal mortality, are increased by x- irradiation.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091470110
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