ISSN:
1432-069X
Keywords:
Scleroderma
;
Platelets
;
Growth factor
;
Endothelial cell survival
;
Antinuclear antibody
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of sera and of platelet-poor plasma from patients with scleroderma on endothelial cell survival in vitro were studied. The survival ratio of rat heart endothelial cells was studied both in 10% test serum and in 10% platelet-poor plasma. Sera from patients with scleroderma decreased the survival ratio significantly when compared with sera from normal controls. In contrast, there was no significant difference between platelet-poor plasma from patients with scleroderma and that from normal controls. Our data indicate that platelets in the patients with scleroderma may cause vascular damage by affecting endothelial cell survival.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00371946
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