ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The alkaline hydrolysis, amidation, and methylation of 4,5-dihydropyrrolo[1,2,3-e,f][1,5]benzodiazepin-6(7H)-one derivatives under various conditions were investigated. The ionization constants (pKα) for 1,2-dimethyl-4,5-dihydro[1,2,3-e,f][1,5]benzodiazepin-6(7H)-one were calculated by the Hammett indicator method, and two values, viz., pK α 1 = −2.37 and pK α 2 = 5.53, which were ascribed to protonation of the diazepine ring and the indole ring of the molecule, respectively, were obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00506047
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