ISSN:
0275-3723
Keywords:
developmental regulation of glycoprotein
;
glycoprotein biosynthesis
;
during life-cycle D discoideum
;
in D discoideum
;
assembly of glycoproteins during development
;
regulation of glycoproteins during development
;
Chemistry
;
Molecular Cell Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
We have examined the glycoprotein-linked oligosaccharides assembled during the life cycle of Dictyostelium discoideum, and found their expression to be dramatically dependent upon the stage of development. During early development mature glycans have a high mannose character, and a substantial proportion acquire a fucose residue that correlates with endo-H resistance. One-third of the glycans also acquire sulfate residues. These glycans diminish in importance during aggregation.The mature glycans expressed during late development contain fewer mannose residues, from five to ten mannose residues, and are characterized by the absence of sulfate residues and by the presence of fucose residues on endo-H-sensitive glycans. These glycans make their appearance coincident with the construction of tips on tight cell mounds. At this stage glycans characteristic of both early and late stages occur simultaneously.Developmental regulation of the wide array of protein-linked glycans expressed during the life cycle of Dictyostelium discoideum may be as simple as the controlled transition from a group of structures that are assembled by the vegetative cells to a group of structures that are assembled by the terminally differentiating cells. The potential biological significance of this transition is discussed.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jsscb.380170407
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