ISSN:
1432-2072
Keywords:
Chlordiazepoxide
;
Dissociation
;
Habituation
;
Open-Field Behavior
;
State-Dependency
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Open-field behavior including ambulation, rearing, defecation and urination were observed in naive rats during a 10 min session each day for 6 consecutive days following administration of D (chlordiazepoxide, 30 mg/kg, p. o.) to Group DD and of S (saline) to Group SS. Group DS received the same dose of D for the first 4 days and S for the last 2 days, while the drug sequence was reversed for Group SD. For the first few min in Session 1, ambulation was slightly more frequent under D than under S and rearing was almost identical in frequency under both states, but afterwards the frequency of both was considerably lowered by D. Defecation (observed twice a session) and urination (observed only after session) were also depressed in drugged rats. A clear intersession habituation was found in all four activities following both S and D, but the habituation was not apparent during the last 5 min of the daily session. The rats subjected to drug-state changes on Day 5 showed increases in these parameters over those with no state change, but this state-dependency was only relative and diminished on the next day.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422809
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