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  • 1
    Digitale Medien
    Digitale Medien
    Teprenone, but not H2-Receptor Blocker or Sucralfate, Suppresses Corpus Helicobacter pylori Colonization and Gastritis in Humans: Teprenone Inhibition of H. pylori-Induced Interleukin-8 in MKN28 Gastric Epithelial Cell Lines (2004)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 9 (2004), S. 0 
    Details
    ISSN: 1523-5378
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background.  The role of teprenone in Helicobacter pylori-associated gastritis has yet to be determined. To investigate the effect of teprenone on inflammatory cell infiltration, and on H. pylori colonization of the gastric mucosa in H. pylori-infected patients, we first compared the effect of teprenone with that of both histamine H2 receptor antagonists (H2-RA) and sucralfate on the histological scores of H. pylori gastritis. We then examined its in vitro effect on H. pylori-induced interleukin (IL)-8 production in MKN28 gastric epithelial cells.Materials and Methods.  A total of 68 patients were divided into three groups, each group undergoing a 3-month treatment with either teprenone (150 mg/day), H2-RA (nizatidine, 300 mg/day), or sucralfate (3 g/day). All subjects underwent endoscopic examination of the stomach before and after treatment. IL-8 production in MKN28 gastric epithelial cells was measured by enzyme-linked immunosorbent assay (ELISA).Results.  Following treatment, the teprenone group showed a significant decrease in both neutrophil infiltration and H. pylori density of the corpus (before vs. after: 2.49 ± 0.22 vs. 2.15 ± 0.23, p = .009; 2.36 ± 0.25 vs. 2.00 ± 0.24, p = .035, respectively), with no significant differences seen in either the sucralfate or H2-RA groups. Teprenone inhibited H. pylori-enhanced IL-8 production in MKN28 gastric epithelial cells in vitro, in a dose-dependent manner.Conclusions.  Teprenone may modify corpus H. pylori-associated gastritis through its effect on neutrophil infiltration and H. pylori density, in part by its inhibition of IL-8 production in the gastric mucosa.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1083-4389.2004.00209.x
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of transjugular intrahepatic portosystemic shunt (TIPS) on esophageal motor function and gastroesophageal reflux (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 305-309 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: TIPS ; esophageal varices ; esophageal motor function ; gastroesophageal reflux
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: The effects of transjugular intrahepatic portosystemic shunt (TIPS) placement on esophageal motor function and gastroesophageal reflux were investigated in patients with esophageal varices. In six men with esophageal varices, esophageal manometry and upper gastrointestinal endoscopy were performed before and 15–20 days after TIPS placement. Intraesophageal pH monitoring was performed in the four patients with severe esophageal varices (defined as the largest sized varices) following TIPS placement. Findings were compared with those in six healthy men (controls) who underwent esophageal manometry and intraesophageal pH monitoring. The esophageal varices resolved or were reduced after TIPS placement. Resting lower esophageal sphincter (LES) pressures were similar in the study group before and after TIPS placement and in the control subjects. The incidence and progression of esophageal contractions were similar in the study group before and after TIPS placement and in the control subjects. At 3 cm above the LES, the amplitude of esophageal contraction after TIPS placement was significantly higher than that before TIPS placement. At 3 and 8 cm above the LES, the amplitude of esophageal contraction in the control subjects was significantly higher than that in the study group before and after TIPS placement. Esophageal acid exposure time after TIPS placement was similar to that in the controls. TIPS placement is a useful treatment that improves esophageal motor function without the occurrence of pathologic gastroesophageal reflux.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350050088
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of body position and liquid meal ingestion on esophageal acid exposure time in healthy subjects (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 139-141 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: body position ; meal ; gastroesophageal reflux ; intraesophageal pH monitoring
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: We investigated the effect of body position and ingestion of a test liquid meal on esophageal acid exposure time in 20 asymptomatic healthy subjects. Intraesophageal pH monitoring was performed for 1 h before meals and 3 h postprandially with the subject in the supine (n = 10) or sitting position (n = 10). The test meal had a total volume of 800 ml and an energy content of 500 kcal. Esophageal acid exposure time was defined as the percentage of time at pH 〈 4.0. There was no difference in preprandial or postprandial esophageal acid exposure time between the supine and sitting positions. Esophageal acid exposure time for the 3-h postprandial period was significantly greater than that for the preprandial period in both the supine and the sitting positions. The difference in body position did not influence preprandial or postprandial esophageal acid exposure time, but ingestion of the liquid meal significantly increased the esophageal acid exposure time in both the supine and sitting positions in asymptomatic healthy subjects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350050060
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  • 4
    Digitale Medien
    Digitale Medien
    Relationship between postprandial esophageal acid exposure and meal volume and fat content (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 926-930 
    Details
    ISSN: 1573-2568
    Schlagwort(e): gastroesophageal reflux ; meal ; fat ; meal volume ; intraesophageal pH monitoring
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of meal volume and fat content on gastroesophageal reflux was investigated in 20 asymptomatic healthy subjects. In each subject, intraesophageal pH monitoring was performed during a 3-hr postprandial period (PP) in the same position (supine or upright) on two successive days. On day 1, 500-ml low- and high-fat meals were ingested and, on day 2, an 800-ml low-fat meal was ingested. The acid exposure time was assessed as the percentage of time with a pH〈4.0. The acid exposure time in subjects in the upright position was significantly longer in the 800-ml group than in the 500-ml group for the entire PP (2.7 ± 1.5%; mean ±se, 0.7 ± 0.4%;P〈0.05). Of subjects in the supine position, the high-fat group showed significantly longer acid exposure time than the low-fat group both for the entire PP (7.6 ± 3.0%, 0.7 ± 0.5%; p〈0.05) and for the second hour (P〈0.05). We have demonstrated that differences in the meal volume and fat content influence gastroesophageal reflux in healthy asymptomatic subjects and that this influence varies with the position.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02091532
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of body position on lower esophageal sphincter pressure (1999)
    Springer
    Journal of gastroenterology 34 (1999), S. 305-309 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: esophageal manometry ; LES ; reflux esophagitis ; esophageal motor function ; body position
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: This study examined the effect of body position on lower esophageal sphincter (LES) pressure. In 36 healthy subjects and 31 patients with reflux esophagitis, LES and intragastric pressures were measured with subjects in the supine and sitting positions by the intraluminal microtransducer method. LES pressure was significantly lower in the sitting position than in the supine position in both healthy subjects and patients with reflux esophagitis. Intragastric pressure was significantly higher in the sitting position than in the supine position in both healthy subjects and patients with reflux esophagitis, but this increase was less marked than the decrease in LES pressure in the sitting position. The overlap of LES pressure values between healthy subjects and patients with reflux esophagitis was lower in the sitting position than in the supine position. We conclude that the measurement of LES pressure in the sitting position reflects LES function more accurately.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350050265
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of nifedipine administration (10 mg) on esophageal acid exposure time (2000)
    Springer
    Journal of gastroenterology 35 (2000), S. 43-46 
    Details
    ISSN: 1435-5922
    Schlagwort(e): Key words: nifedipine, esophageal acid exposure time, reflux esophagitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 11 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position, preprandially (1 h) and 3-h postprandially after oral administration of a placebo in the morning and oral administration of nifedipine (10 mg) in the afternoon on the same day. In the non-RE patients, there was no difference in the esophageal acid exposure time between administration of the placebo and that of nifedipine. In patients with RE, the esophageal acid exposure time after the administration of nifedipine was significantly (P 〈 0.05) longer than that after the placebo. In patients with severe RE, the severity of RE may worsen with nifedipine administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005350050008
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