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  • 1
    Electronic Resource
    Electronic Resource
    Investigation of DNA synthesis in experimentally induced Long-Evans rat myeloschisis by the BrdU/antiBrdU technique (1994)
    Springer
    Child's nervous system 10 (1994), S. 180-184 
    Details
    ISSN: 1433-0350
    Keywords: Myeloschisis ; DNA synthesis ; Overgrowth ; Long-Evans rat ; Ethylenethiourea ; Bromodeoxyuridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The volume and DNA synthesis of the neuroepithelium in induced myeloschisis in Long-Evans rats as shown by hematoxylin-eosin and BrdU/antiBrdU immunohistochemical staining patterns were examined at different stages of embryonal development. On day 14 of gestation, control animals contained BrdU-incorporating cells mainly at the alar plate of the closed neural tube. On the same day, the everted neural plate of rats with myeloschisis showed active, diffuse uptake of BrdU in the cells of the matrix layer, although an increase in the volume of the everted neural plate was not yet identifiable. On day 21 of gestation, rats with myeloschisis showed a marked increase in the volume of the neuroepithelium compared with controls. Our investigations suggest that, in myeloschisis, more neuroepithelial cells than normal retain their capability for DNA synthesis on day 14 of gestation, and the overgrowth of the neuroepithelium found on day 21 is possibly a secondary effect of failure of neural tube closure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301087
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  • 2
    Electronic Resource
    Electronic Resource
    Surgical treatment of syringomyelia associated with spinal dysraphism (1997)
    Springer
    Child's nervous system 13 (1997), S. 194-200 
    Details
    ISSN: 1433-0350
    Keywords: Key words Spinal dysraphism ; Syringomyelia ; Magnetic resonance imaging ; Syringo-subarachnoid shunt ; Chiari malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical and radiological features of syringomyelia in 15 patients with spinal dysraphism are reported. There were 8 patients with occult spinal dysraphism (lumbosacral lipoma) and 7 with spina bifida aperta (meningomyelocele). Syringomyelia with spinal dysraphism can be radiologically divided into two types according to the dysraphic state. The syrinx in the patients with occult spinal dysraphism occurred immediately rostral to the lipoma and was localized to the lower thoracic to lumbar levels, while in the meningomyelocele patients the syrinx extended from the cervical to the thoracic level. Large syrinx formation was recognized in 1 of the 7 occult spinal dysraphism cases and 3 of the 8 meningomyelocele cases. For syringomyelia with occult spinal dysraphism, 4 patients underwent syringo-subarachnoid shunting (S-S shunt, 2 cases) or syringostomy (2 cases) during an untethering operation. In the case of meningomyelocele, S-S shunts were placed in 2 patients. Collapse of the syrinx was achieved in all 6 patients who underwent S-S shunting or syringostomy. Decreased size of the syrinx was also noted in 3 occult spinal dysraphism patients who underwent untethering operations alone. In conclusion, a large syrinx in the case of spinal dysraphism should be surgically treated. S-S shunting is effective in both types of syringomyelia. Foramen magnum decompression may be an alternative method of surgical treatment for syringomyelia in patients with meningomyelocele.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050068
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A split cord malformation (1998)
    Springer
    Child's nervous system 14 (1998), S. 398-400 
    Details
    ISSN: 1433-0350
    Keywords: Key words Split cord malformation ; Diastematomyelia ; Tethered cord ; MRI ; CT myelography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report describes a case of split cord malformation without a septum. A 2-year-old boy presented with a 3-month history of neurogenic bladder. MRI did not show any apparent abnormality around the conus medullaris. However, CT myelography clearly demonstrated the presence of a split filum terminale. The patient underwent laminectomy of L1–5 laminas and untethering of the split filum terminale. CT myelography was superior to MRI in diagnosing split cord malformation in this case. As MRI is currently regarded as the superior imaging modality, this reported case may have been missed because the pathology was not apparent on MRI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050253
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  • 4
    Electronic Resource
    Electronic Resource
    Surgical treatment supposed natural history of the tethered cord with occult spinal dysraphism (1997)
    Springer
    Child's nervous system 13 (1997), S. 268-274 
    Details
    ISSN: 1433-0350
    Keywords: Key words Occult spinal dysraphism ; Tethered cord ; Lumbosacral lipoma ; Tight filum terminale ; Surgical treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We retrospectively evaluated the pre- and postoperative course of 34 tethered cord patients with occult spinal dysraphism in an attempt to infer the natural history of this disorder and to determine the effectiveness of the surgical treatment. There were 32 cases with lumbosacral lipoma and 2 with tight filum terminale. The age at surgery ranged from 1 month to 47 years old. Eight patients, aged 1 month to 4 years old, were asymptomatic; 26 had neurogenic bladder (26 cases) or motor problems affecting the legs (8 cases). None of the patients older than 5 years of age were asymptomatic. Untethering of the spinal cord was performed in all cases. The postoperative follow-up period ranged from 5 months to 11 years. During these periods, 7 (88%) of the 8 asymptomatic patients remained neurologically intact, 6 (23%) of the 26 symptomatic patients showed improved symptoms, and 15 patients (58%) remained unchanged. These results indicate that the neurological symptoms will appear progressively in the tethered cord patients, and that prophylactic surgery should be considered as early as possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050081
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  • 5
    Electronic Resource
    Electronic Resource
    Scoliosis associated with syringomyelia presenting in children (1992)
    Springer
    Child's nervous system 8 (1992), S. 97-100 
    Details
    ISSN: 1433-0350
    Keywords: Chiari malformation ; Children ; Magnetic resonance imaging ; Scoliosis ; Syringomyelia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical presentations and radiological features of scoliosis accompanying syringomyelia were analyzed in 14 cases of syringomyelia associated with a Chiari malformation in children. Scoliosis was the initial symptom in 11 out of 16 patients (64%) with syringomyelia and present in 14 (88%) at the initial examination. The scoliosis associated with syringomyelia was characterized by a higher incidence of a single curve (6 cases, 43%) and convexity to the left (7 cases, 50%) than seen in idiopathic scoliosis. The syrinx was shifted to the convex side of scoliosis on the axial section at the middle or lower thoracie level in patients with a single curve, and at the cervical or upper thoracic level in patients with a double curve. The authors think that the scoliosis develops in children as a result of damage done to the anterior horn, which innervates the muscles of the trunk, by an asymmetrically expanded syrinx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298449
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