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  • 1
    Electronic Resource
    Electronic Resource
    Efficacy and tolerability of multiple-dose SDZ IMM 125 in patients with severe psoriasis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although cyclosporin is effective in immunosuppression following organ transplantation and in the treatment of psoriasis, its use is limited by its side-effects, notably impaired renal function and hypertension. As SDZ IMM 125, a new derivative of the cyclosporin family, showed considerable immunosuppressive activity in experimental studies, with less effect on renal function, it was considered a potential successor to cyclosporin for both indications. In this multicentre, double-blind, placebo-controlled study, the efficacy and tolerability of 40, 100, 200 and 400mg SDZ IMM 125 daily were studied in 59 patients with psoriasis. Patients were followed for a period of 5 weeks (4 weeks treatment, and 1 week post-treatment observation). A dose-dependent effect of SDZ IMM 125 was observed. A significant correlation was found between the dose of SDZ IMM 125 and changes in the sum of severity scores of three indicator plaques. There was a significant decrease in the body surface area affected by psoriasis in the 400-mg group (P 〈 0.01), whereas a decrease of the global psoriasis severity was observed in the 200-mg (P 〈 0.01) and the 400-mg groups (P 〈 0.001). No serious adverse events occurred during the 4 weeks of treatment. Three patients discontinued treatment because of adverse events (one sore throat, two influenza). Clinical adverse events were similar to those reported with cyclosporin, the most frequent being gastrointestinal disturbances. Estimation of renal function indices showed that increases from baseline values were dose dependent, and appeared to be similar to those seen with cyclosporin. Changes in liver function tests showed a clearcut dose-dependent increase of some liver enzymes, principally alanine aminotransferase (ALAT). SDZ IMM 125 is effective in clearing psoriasis. However, long-term studies comparing the efficacy and safety of SDZ IMM 125 and cyclosporin must be performed, to determine whether SDZ IMM 125 has a better risk-benefit ratio than cyclosporin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02500.x
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  • 2
    Electronic Resource
    Electronic Resource
    Microinjection of an antibody against HSP 72 in keratinocytes to study acute UV injury〈link href="#fn1"〉⊃〈/link〉 (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: First, a method of microinjection of antibodies in primary human keratinocytes in culture was established. Second, in acute UV irradiation, the physiological role of heat shock protein (HSP) 72 in keratinocytes was studied with this method. Primary human keratinocytes in culture were injected with “controls” as fluorescent dyes, phosphate buffered saline (PBS), an irrelevant secondary antibody and an antibody against a protein with known protective function in UV erythema, HSP 72. UV irradiation was applied and survival, colony forming and immunohistochemistry for injected and non-injected keratinocytes were evaluated in a time course. Puncturing the plasma membrane with injections of “controls” as FITC, PBS and the IgG anti-mouse antibody did not result in reflux of injected material or any alteration in morphology or colony-forming ability for 24 h. Keratinocytes injected with an mAb to HSP 72 without UV irradiation survived microinjection for up to 12 days, while surprisingly, more than double of injected and irradiated ones died after 12 h compared to not injected and irradiated ones. Moreover, microinjection of the antibody to HSP 72 in the nucleus resulted in a loss of the immunohistochemical labeling for HSP 72 in these cells after 12 h. Microinjection of the “controls” did not harm the survival, forming of colonies and expression of HSP 72 in keratinocytes for 24 h. In contrast, microinjection of an mAb against HSP 72 led to an increase in cell death after UV irradiation, confirming that HSP 72 is important for UV protection. Microinjection of antibodies in human keratinocytes in culture might allow the study of the physiological role of some proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00378.x
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of p53 protein in malignant melanoma: clinicopathological and prognostic implications (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the present study, we investigated the expression of the tumour suppressor protein p53 in 1 primary and 43 metastatic malignant melanomas by immunohistochernistry, and correlated the findings with clinicopathological parameters such as histological melanoma subtype, thickness of primary melanomas (Breslow thickness) and patient outcome.In primary melanomas, the polyclonal anti-p5 3 antibody CM-1 detected immunoreactivity in 70% of the lesions, predominantly in the cytoplasm. Signals were observed in this cellular compartment in 57% of the melanomas, whereas in 32% nuclear p53 over-expression was detected. Immunohis-tochemistry, using the monoclonal antibody DO-1, revealed lower staining frequencies. However, both antibodies showed congruent results in approximately 80% of the cases. Overall, immuno-reactivity was observed in 73% of superficial spreading melanomas, but only in 52% of lentigo maligna melanomas. This difference (P〈0.001) was mainly due to a lower frequency of cytoplasmic immunoreactivity (P〈0.002). There was no difference with respect to cytoplasmic and nuclear immunoreactivity between thin (〈1 mm thickness) and thicker primary melanomas. Staining frequencies detected in metastatic lesions seemed to be lower than in primary tumours. In 103 primary melanomas, follow-up data for at least 5 years were available. In 71% (54 of 76) of the primary melanomas which did not recur, and in 78% (21 of 27) of tumours with subsequent metastases, p53 over-expression was detected by CM-1. However, this difference was not statistically significant.The results of the present study indicate that immunoreactivity to anti-p53 antibodies is a common observation in malignant melanomas, with staining signals predominantly found in the cytoplasm of cells. The observation of similar staining frequencies in thin, thick and metastatic lesions indicates that p53 over-expression is an early event in the pathogenesis of malignant melanoma. However, the immunohistochemical detection of p53 in primary melanomas is not related to prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02487.x
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  • 4
    Electronic Resource
    Electronic Resource
    Photoallergie durch 4-chlor-2-hydroxy-Benzoesäure-n-Butylamid (1968)
    Springer
    Archives of dermatological research 232 (1968), S. 403-412 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Photoallergie durch das lokale Antimycoticum 4-Chlor-2-hydroxy-Benzoesäure-n-Butylamid (Jadit®) wird in vitro die lichtinduzierte Jadit-Proteinkoppelung und die Antigenität dieses Komplexes untersucht. Durch Bestrahlung einer Jadit-Serum-Mischung kann eine feste Bindung von Jadit an die Serumalbumine erreicht werden, ohne daß Jadit in der Eigenschaft seiner Fluorescenz bei 254 nm verändert wird. Die Serumproteine werden dadurch in ihren elektrophoretischen Eigenschaften nicht nachweisbar alteriert. Zum in vitro-Nachweis der Antigenität des Jadit-Protein-Komplex wird der Lymphoblastentransformationstest (LTT) modifiziert und angewandt. Die optimale Hapten-Konzentration für Jadit beträgt 7 γ/ml Kulturansatz. Die LTT bei zehn Patienten mit nachgewiesener Photoallergie und bei einer Kontrollgruppe von zehn gesunden Personen zeigen, daß nur dem photochemisch gebildeten Jadit-Albumin-Komplex antigene Eigenschaften zukommen. Diese Resultate konnten statistisch bei einer Irrtumswahrscheinlichkeit von 0,01 gesichert werden.
    Notes: Summary In the photoallergy to an antimycotic agent for topical use, 4-chloro-2-hydroxybenzoic-acid-n-butylamide (Jadit®), the light-induced protein combination of this substance and the antigenicity of the complex thus formed is investigated. The irradiation of Jadit and serum leads to a firm combination of Jadit and albumin, without alteration of either the typical fluorescence of Jadit (254 nm) or the electrophoretic properties of albumin. The antigenicity of the light-induced complex Jadit-albumin is confirmed by a modification of the lymphocyte transformation test (LTT). The optimal concentration of the hapten is 7 γ/ml culture medium. The LTT on 10 patients suffering from a photocontact dermatitis due to Jadit, and on a control group of 10 normal persons, demonstrates that only the light-induced complex Jadit-albumin acts as an antigen. These results are statistically confirmed by a level significance of 0.01.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503629
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  • 5
    Electronic Resource
    Electronic Resource
    Photoallergie durch 4-Chlor-2-hydroxy-Benzoesäure-n-Butylamid (1968)
    Springer
    Archives of dermatological research 233 (1968), S. 287-295 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Photoallergie durch das lokale Antimykoticum 4-Chlor-2-hydroxy-benzoesäure-n-butylamid (Jadit®) werden die photochemischen Schritte untersucht, die zur Antigenbildung durch Proteinkopplung führen. Bei Bestrahlung von Jadit auf der Hautoberfläche kommt dieser Substanz ein Schutzeffekt gegen UV C zu. Bei Bestrahlung in Alkali kann eine photochemische Umwandlung in mehreren Schritten beobachtet werden. Der erste Schritt besteht in einer Chlor-Abspaltung mit Bildung von freinen Radikalen. In der Folge kommt es zu einer Dimerisierung von Jaditradikalen mit weiteren Jaditmolekülen. Dem dimeren Produkt kommt keine allergologische Bedeutung zu. Erfolgt die Bestrahlung in der Haut oder in Gegenwart von Serumalbuminen, so koppeln sich die lichtinduzierten Radikale direkt an die Proteine zum vollständigen Antigen.
    Notes: Summary In the photoallergy to an antimycotic agent for topical use, 4-chloro-2-hydroxybenzoic-acid-n-butylamine (Jadit®), the photochemical mechanism of antigen formation is investigated. Applied on the surface of skin the substance acts as a UV C protector. By irradiation in alkaline solutions a photochemical degradation occurs in various steps. The first step is suggested to be a splitting off of chlorine leading to the formation of free radicals. In further steps a recombination of those radicals into dimere products is observed. In contact with the skin or serum albumine these light induced free radicals are directly attached to protein to form a complete antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496446
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  • 6
    Electronic Resource
    Electronic Resource
    In vitro-Untersuchungen zur Chlorpromazine (CPZ)-Photoallergie (1970)
    Springer
    Archives of dermatological research 237 (1970), S. 501-506 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Chlorpromazin (CPZ) bildet unter Aufnahme von Lichtquanten Radikale, die zu einer zunächst reversiblen, später stabilen Dimersierung führen. Im radikalen Zustand vermag sich CPZ mit biologischen Substraten zu koppeln. Die Bindung mit Proteinen bildet die Grundlage zur Photoallergie, diejenige mit RNS zur phototoxischen Wirkung und diejenige mit Melanoprotein zur CPZ-Pigmentierung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00641879
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  • 7
    Electronic Resource
    Electronic Resource
    Experimentelle Herpes simplex-Virus-Infektion auf der Haut haarloser Mäuse (1970)
    Springer
    Archives of dermatological research 239 (1970), S. 22-29 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auf der Haut haarloser Mäuse wurde eine Herpes simplex-Virus-Infektion erzeugt, die mit Herpes simplex-Elementen der menschlichen Haut vergleichbar ist. Die Infektion erfolgte durch Scarifikation der Haut. Ihre Spezifität wurde histologisch und virologisch bewiesen. Als Besonderheit zeigten die Erosionen auf der Mäusehaut eine segmentale, zosteriforme Ausbreitung. Ferner traten neurologische Symptome auf. Die experimentelle Herpes simplex-Virus-Infektion der Mäusehaut kann als Modellinfektion zur Untersuchung der Herpes simplex-Virus-Infektion der menschlichen Haut und ihrer Therapie dienen.
    Notes: Summary Herpesvirus infection of the skin of adult mice of a hairless mouse strain induced eruptions comparable to herpes eruptions in man. The route of infection was by scarification of the skin. The specificity of the lesions was varified histologically and by isolation of Herpesvirus from the lesions. The eruptions spread segmentally similarly to the spread of Herpes zoster in man. Neurological symptoms comprising increasing paralysis were first observed to affect those extremities nearest to the site of initial infection. In later stages, the animals showed symptoms of encephalitis. The infection of hairless mouse skin may serve as a model for the study of the pathogenesis and therapy of Herpesvirus infection of human skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519553
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  • 8
    Electronic Resource
    Electronic Resource
    Sister chromatid exchange (SCE) in human lymphocytes (1979)
    Springer
    Archives of dermatological research 265 (1979), S. 283-287 
    Details
    ISSN: 1432-069X
    Keywords: SCE ; UV C ; Age ; SCE ; UV C ; Alter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Zahl von “Sister chromatid exchanges” (SCE) pro Metaphase wurde mit der Hoechst-Giemsa-Technik an menschlichen Lymphocyten bestimmt. Eine UV C-Bestrahlung führt im Bereiche von 0–40 mJ/cm2 dosisabhängig zu einer Vermehrung von SCE. Es kann kein Unterschied dieses Phänomens beobachtet werden zwischen einer Gruppe junger (20–40jährig) und alter (60–80jährig) Freiwilliger.
    Notes: Summary The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. UV C irradiation promotes SCE dose-dependent in the range of 0–40 mJ/cm2. No difference of this phenomenon may be observed, compairing young volunteers (20–40 years) with a 60–80-year-old group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412385
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  • 9
    Electronic Resource
    Electronic Resource
    Nevoid basal cell carcinoma syndrome (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 218-218 
    Details
    ISSN: 1432-069X
    Keywords: Nevoid basal cell carcinoma syndrome ; Sister chromatid exchanges
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456400
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  • 10
    Electronic Resource
    Electronic Resource
    Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 213-216 
    Details
    ISSN: 1432-069X
    Keywords: Merkel cells ; Actinic skin damage ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Merkel cells (MCs), the neuroendocrine cells of the skin cannot be identified with certainty using conventional light microscopic staining methods. Using immunoperoxidase microscopy with antibodies specific for cytokeratin 18, which has been established as a marker protein of MCs, we have evaluated the numbers of MCs per mm2 skin in normal and sun-damaged upper arm skin. The sun-exposed skin contained twice as many MCs as the not sun exposed skin. Further quantification of MC density at various body sites (trunk, leg) showed a rather variable but often unexpectedly high MC density. The possible role of MC in development of actinic elastosis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371638
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