ISSN:
1365-4632
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
: A pilot study was conducted in the first of two monkeys using either radiolabeled Dm-Na-P or radiolabeled hydrocortisone sodium succinate, together with lidocaine HCI. This study indicated an approximately tenfold increase in the quantity of Dm-Na-P delivered to the test electrodes (4 mA; 20 minutes) whereas the quantity of hydrocortisone delivered from the test electrodes was only marginally (≅10%) increased as compared with that from the controls. In terms of an antiinflammatory activity, the effective dose of Dm-Na-P in all tissue layers underlying the test electrodes was at least tenfold that of the hydrocortisone. Therefore, further trials with hydrocortisone were abandoned.In the Second animal, positive test electrodes (5 mA; 20 minuter, were sited over five joints on the right side of the body and matching control electrodes (0 mA: 20 minutes) were placed over corresponding joints on the left side of the body. The control and test electrodes each contained 1.0 ml tritiumlabeled Dm-Na-P (≅4.0 mg) and 2.0 ml 4% lidocaine HCI (80mg).Local tissue concentrations of Dm-Na-P were higher than those that would be obtained by systematic therapy and lower than would be obtained by injection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-4362.1980.tb00380.x
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