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  • 1
    Electronic Resource
    Electronic Resource
    New chapter in skin biopsy: diagnostic tool for neurodegenerative disorders (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The accumulation of the ubiquitous amyloid peptide in the brain is a defining feature of Alzheimer's disease. Consistent with studies demonstrating alterations of various biochemical processes of cells of peripheral tissues and the importance of skin biopsy in the diagnosis of neurodegenerative disorders, we investigated whether differences in the basal intracellular free calcium levels of lymphocytes and cultured cutaneous fibroblasts derived from sporadic Alzheimer patients and from age-matched control individuals might be present. Calcium levels were measured in Fura-2AM-loaded human fibroblasts by dual-wavelength spectrofluorimetry. Basal calcium levels appeared to be higher in Alzheimer lymphocytes when compared with control ones. Resting calcium concentration of Alzheimer fibroblasts, however, has proved to be lower than that seen with control cells. Exposure of cells to amyloid resulted in the elevation in the Ca2+ level of both control cell types, however, that of Alzheimer lymphocytes and fibroblasts did not differ considerably. Our test could prove useful in supporting the diagnosis of (sporadic) AD in patients suspected of suffering from the disease. Also, this simple finding may serve as a springboard to monitoring Alzheimer pathology in the peripheral systems of the body.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.0212cj.x
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  • 2
    Electronic Resource
    Electronic Resource
    Alteration of erythrocyte phosphate transport in primary depressive disorders
    Amsterdam : Elsevier
    Journal of Affective Disorders 2 (1980), S. 229-238 
    Details
    ISSN: 0165-0327
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-0327(80)90024-5
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sodium-dependent lithium efflux from red cells in affective disorders
    Amsterdam : Elsevier
    Psychiatry Research 1 (1979), S. 265-272 
    Details
    ISSN: 0165-1781
    Keywords: Sodium-dependent lithium efflux ; affective psychoses ; lithium therapy ; red blood cells
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1781(79)90008-8
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of external sodium and potassium on lithium uptake by primary brain cell cultures at ‘therapeutic’ lithium concentration (1980)
    Springer
    Psychopharmacology 71 (1980), S. 159-163 
    Details
    ISSN: 1432-2072
    Keywords: Lithium uptake ; Brain cell cultures ; Sodium and potassium effect ; Lithium homeostasis ; Lithium therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ionic regulating of lithium homeostasis and steady-state intra: extracellular lithium distribution in the brain can be approached by experimental methods using intact nerve cells in vitro. Primary cultures prepared from chick embryonic brain were applied to study the effect of extracellular sodium and potassium on the lithium uptake of nerve cells at ‘therapeutic’ lithium concentration (1.5 mM). Lithium influx and the level of steady-state intracellular lithium were significantly reduced by increasing the external sodium concentration. At physiological extracellular sodium level, the steady-state content of lithium in the brain cells was about half of that observed in the presence of 10 mM sodium in the incubation media and the value of the intra: extracellular lithium distribution ratio was below 1. External potassium (0.5–3 mM) strongly inhibited lithium uptake of the nerve cells. Ouabain (10-4 M) had no effect on this potassiumsensitive lithium uptake in Tyrode media. Sodium influx studied by isotope tracer methodology was higher in cultures preloaded with lithium as compared to that of the controls. It can be concluded that sodium and potassium ions, at physiological concentrations, significantly influence lithium uptake as well as the intra: extracellular lithium distribution in brain cell cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434405
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  • 5
    Electronic Resource
    Electronic Resource
    Steady-state distribution of lithium during cultivation of dissociated brain cells (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1071-1072 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The formation of a steady-state intracellular lithium level was studied in the course of cultivation of dissociated nerve cell cultures obtained from chick embryonic brains. When lithium was given at a concentration of 2 mM, in the nutrient medium, at day 5, a steady state intracellular lithium content was achieved after about 30 min of incubation and it did not change significantly during the time of cultivation up to the 13th day in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965976
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of lithium on morphological characteristics of dissociated brain cells in culture (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 117-121 
    Details
    ISSN: 1432-0533
    Keywords: Lithium therapy ; Toxicity ; Nerve cell culture ; Development ; Neural processes ; Swelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lithium chloride was added in 5 and 10 mM concentrations for different periods of exposition time to dissociated cultures obtained from chicken embryonic brain. When supplementing lithium at day 1 in vitro for five days, a dose-dependent decrease in total protein was observed in the cultures as compared to the sodium-treated controls. Profound reduction was revealed in the length of neuronal processes and in the number of neuronal cell bodies by phase contrast microscopy and by morphometric means. After exposition of lithium in 10 mM concentration for 48 h, beside a slight decrease in number of perikaryons, a marked reduction in process length of neural elements was observed in the 6-day-old tissue cultures. Ultrastructurally, swollen and degenerating nerve processes have been found after lithium treatment suggesting a particular sensitivity of these structures to lithium ion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684812
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  • 7
    Electronic Resource
    Electronic Resource
    P300 component of visual event-related potentials distinguishes patients with idiopathic Parkinson's disease from patients with essential tremor (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 787-797 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease ; essential tremor ; "oddball" paradigm ; visual P300 ; visual event-related potentials.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. A considerable rate of misdiagnosis has recently been reported in movement disorders. One of the most difficult clinical problems is the differentiation of Parkinson's disease and essential tremor. In this study, we have examined whether event-related potentials (ERPs) could aid in the solution of this differential diagnostic problem. Visual ERPs were obtained by using an "oddball" paradigm in 20 patients with idiopathic Parkinson's disease (IPD), 20 patients with essential tremor (ET), and 20 age-matched control subjects. We found that the P300 amplitudes were selectively reduced in the IPD group at the midline (Fz, Cz, Pz) electrode sites, whereas the ET group exhibited selectively elevated P300 amplitudes at the left parietal and frontal (F3, P3) recording sites. The patients with IPD, but not ET, showed a significant prolongation of the P300 latency at each electrode site. Similarly, only the IPD patients were significantly slower in responding to the target stimulus. The primary visual evoked potential (P100) did not distinguish among the IPD, ET, and control subjects. These results suggest that visual ERPs might provide a useful diagnostic method for differentiating IPD from ET.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070059
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